DK1381356T3 - Anvendelse af (z)-z-cyano-3-hydroxy-but-2-enoinsyre-(4-trifluoromethylphenyl) - amide til behandling af multipel sclerose - Google Patents
Anvendelse af (z)-z-cyano-3-hydroxy-but-2-enoinsyre-(4-trifluoromethylphenyl) - amide til behandling af multipel scleroseInfo
- Publication number
- DK1381356T3 DK1381356T3 DK02763962T DK02763962T DK1381356T3 DK 1381356 T3 DK1381356 T3 DK 1381356T3 DK 02763962 T DK02763962 T DK 02763962T DK 02763962 T DK02763962 T DK 02763962T DK 1381356 T3 DK1381356 T3 DK 1381356T3
- Authority
- DK
- Denmark
- Prior art keywords
- trifluoromethylphenyl
- cyano
- amide
- hydroxy
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28168501P | 2001-04-05 | 2001-04-05 | |
GBGB0123571.2A GB0123571D0 (en) | 2001-04-05 | 2001-10-02 | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
PCT/US2002/010773 WO2002080897A1 (en) | 2001-04-05 | 2002-04-04 | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1381356T3 true DK1381356T3 (da) | 2008-09-22 |
Family
ID=26246599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02763962T DK1381356T3 (da) | 2001-04-05 | 2002-04-04 | Anvendelse af (z)-z-cyano-3-hydroxy-but-2-enoinsyre-(4-trifluoromethylphenyl) - amide til behandling af multipel sclerose |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP1935416A3 (de) |
AR (1) | AR033459A1 (de) |
AT (1) | ATE396719T1 (de) |
CA (1) | CA2443285C (de) |
CY (1) | CY2014004I1 (de) |
DE (1) | DE60226855D1 (de) |
DK (1) | DK1381356T3 (de) |
ES (1) | ES2305287T3 (de) |
FR (1) | FR14C0010I2 (de) |
LU (1) | LU92366I2 (de) |
PA (1) | PA8542901A1 (de) |
PT (1) | PT1381356E (de) |
SI (1) | SI1381356T1 (de) |
UY (1) | UY27244A1 (de) |
WO (1) | WO2002080897A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054608A2 (en) | 2002-12-12 | 2004-07-01 | Agennix Incorporated | Lactoferrin in the reduction of pain |
BRPI0518205A (pt) * | 2004-10-19 | 2008-11-04 | Aventis Pharma Inc | uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino |
DK1828160T3 (da) | 2004-12-21 | 2012-02-13 | Merck Serono Sa | Cykliske sulfonylaminoderivater og anvendelse deraf som MMP-hæmmere |
JP4950070B2 (ja) | 2005-01-31 | 2012-06-13 | メルク セローノ ソシエテ アノニム | N−ヒドロキシアミド誘導体及びその使用 |
EP1933860A2 (de) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Behandlung von optikusneuritis |
ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
EP2100881A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Pyrimidinyl- oder Pyridinylaminobenzoesäurederivate |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2135610A1 (de) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Kombination mit DHODH-Inhibitoren und Methotrexat |
EP2228367A1 (de) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Zusatzsalze von Aminen mit Hydroxyl- und/oder Carboxylgruppen mit Aminonicotinsäurederivaten als DHODH-Inhibitoren |
EP2230232A1 (de) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Zusatzsalze von Tromethamin mit Azebiphenylaminobenzoesäurederivate als DHODH-Inhibitoren |
EP2239256A1 (de) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Natriumsalz von 5-cyclopropyl-2-{[2-(2,6-difluorphenyl)pyrimidin-5-yl]amino}benzoesäure als DHODH-Inhibitor |
EP2277515A1 (de) * | 2009-07-10 | 2011-01-26 | Sanofi-Aventis | Verwendung der Kombination aus Teriflunomid und Interferon beta zur Behandlung der multiplen Sklerose |
ME02765B (de) * | 2009-09-18 | 2018-01-20 | Sanofi Sa | (z)-2-cyano-3-hydroxy-but-2-ensäure-(4' trifluormethylphenyl)-amid-tablettenformulierungen mit erhöhter stabilität |
EP2314577A1 (de) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Verfahren zur Herstellung von 2-[(3,5-Difluor-3'-methoxy-1,1'-biphenyl-4-yl)amino]nikotinsäure |
US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
EP2672963A4 (de) | 2011-02-08 | 2015-06-24 | Childrens Medical Center | Verfahren zur behandlung von melanomen |
EP2762135A1 (de) * | 2013-02-04 | 2014-08-06 | Sanofi | Verfahren zur Verringerung des Risikos auf einer schädlichen Teriflunomid- und Rosuvastatininteraktion bei Patienten mit Multipler Sklerose |
US20180147148A1 (en) | 2015-05-23 | 2018-05-31 | Ftf Pharma Private Limited | Pharmaceutical composition of teriflunomide |
JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
GR1010137B (el) | 2020-12-15 | 2021-12-07 | Φαρματεν Α.Β.Ε.Ε., | Στερεη φαρμακοτεχνικη μορφη αμεσης αποδεσμευσης περιεχουσα τεριφλουνομιδη και μεθοδος παρασκευης αυτης |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES448386A1 (es) | 1975-06-05 | 1978-04-16 | Hoechst Ag | Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico. |
DE2854439A1 (de) | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
DE3534440A1 (de) | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
US5268382A (en) | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
TW314467B (de) | 1993-03-31 | 1997-09-01 | Hoechst Ag | |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
DE19547648A1 (de) * | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
-
2002
- 2002-04-04 CA CA002443285A patent/CA2443285C/en not_active Expired - Fee Related
- 2002-04-04 EP EP08004647A patent/EP1935416A3/de not_active Ceased
- 2002-04-04 ES ES02763962T patent/ES2305287T3/es not_active Expired - Lifetime
- 2002-04-04 EP EP02763962A patent/EP1381356B1/de not_active Expired - Lifetime
- 2002-04-04 SI SI200230727T patent/SI1381356T1/sl unknown
- 2002-04-04 PT PT02763962T patent/PT1381356E/pt unknown
- 2002-04-04 AR ARP020101245A patent/AR033459A1/es not_active Application Discontinuation
- 2002-04-04 AT AT02763962T patent/ATE396719T1/de active
- 2002-04-04 DE DE60226855T patent/DE60226855D1/de not_active Expired - Lifetime
- 2002-04-04 WO PCT/US2002/010773 patent/WO2002080897A1/en not_active Application Discontinuation
- 2002-04-04 DK DK02763962T patent/DK1381356T3/da active
- 2002-04-05 UY UY27244A patent/UY27244A1/es unknown
- 2002-04-05 PA PA20028542901A patent/PA8542901A1/es unknown
-
2014
- 2014-01-23 CY CY2014004C patent/CY2014004I1/el unknown
- 2014-01-29 LU LU92366C patent/LU92366I2/fr unknown
- 2014-02-05 FR FR14C0010C patent/FR14C0010I2/fr active Active
Also Published As
Publication number | Publication date |
---|---|
EP1381356A1 (de) | 2004-01-21 |
PT1381356E (pt) | 2008-07-24 |
DE60226855D1 (de) | 2008-07-10 |
ES2305287T3 (es) | 2008-11-01 |
AR033459A1 (es) | 2003-12-17 |
EP1935416A2 (de) | 2008-06-25 |
CY2014004I2 (el) | 2015-12-09 |
PA8542901A1 (es) | 2003-11-12 |
FR14C0010I1 (de) | 2014-03-14 |
EP1381356B1 (de) | 2008-05-28 |
SI1381356T1 (sl) | 2008-12-31 |
LU92366I2 (fr) | 2014-03-31 |
EP1935416A3 (de) | 2008-10-22 |
ATE396719T1 (de) | 2008-06-15 |
UY27244A1 (es) | 2002-07-31 |
CY2014004I1 (el) | 2015-12-09 |
CA2443285A1 (en) | 2002-10-17 |
CA2443285C (en) | 2007-08-21 |
WO2002080897A1 (en) | 2002-10-17 |
FR14C0010I2 (fr) | 2014-11-21 |
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