DK1290011T3 - Melphalan-derivater og deres anvendelse som cancer-kemoterapeutiske lægemidler - Google Patents

Melphalan-derivater og deres anvendelse som cancer-kemoterapeutiske lægemidler

Info

Publication number
DK1290011T3
DK1290011T3 DK01938945.1T DK01938945T DK1290011T3 DK 1290011 T3 DK1290011 T3 DK 1290011T3 DK 01938945 T DK01938945 T DK 01938945T DK 1290011 T3 DK1290011 T3 DK 1290011T3
Authority
DK
Denmark
Prior art keywords
chemotherapeutic drugs
cancer chemotherapeutic
melphalan
melphalan derivatives
derivatives
Prior art date
Application number
DK01938945.1T
Other languages
Danish (da)
English (en)
Inventor
Rolf Larsson
Rolf Lewensohn
Joakim Gullbo
Hans Ehrsson
Kristina Luthman
Original Assignee
Oncopeptides Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncopeptides Ab filed Critical Oncopeptides Ab
Application granted granted Critical
Publication of DK1290011T3 publication Critical patent/DK1290011T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK01938945.1T 2000-06-13 2001-06-11 Melphalan-derivater og deres anvendelse som cancer-kemoterapeutiske lægemidler DK1290011T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21122700P 2000-06-13 2000-06-13
SE0002202A SE0002202D0 (sv) 2000-06-13 2000-06-13 New peptides
PCT/SE2001/001318 WO2001096367A1 (en) 2000-06-13 2001-06-11 Melphalan derivatives and their use as cancer chemotherapeutic drugs

Publications (1)

Publication Number Publication Date
DK1290011T3 true DK1290011T3 (da) 2010-06-07

Family

ID=20280067

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01938945.1T DK1290011T3 (da) 2000-06-13 2001-06-11 Melphalan-derivater og deres anvendelse som cancer-kemoterapeutiske lægemidler

Country Status (10)

Country Link
EP (1) EP1290011B1 (enExample)
JP (1) JP4798930B2 (enExample)
AT (1) ATE458746T1 (enExample)
AU (1) AU2001264515A1 (enExample)
CA (1) CA2408501C (enExample)
DK (1) DK1290011T3 (enExample)
ES (1) ES2341702T3 (enExample)
PT (1) PT1290011E (enExample)
SE (1) SE0002202D0 (enExample)
WO (1) WO2001096367A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1374907A3 (en) * 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system
DE10239832A1 (de) * 2002-08-29 2004-03-18 Lipal Biochemicals AG c/o University of Zurich Sarcolysyl-Derivate und Verfahren zu deren Herstellung
WO2011011865A1 (en) * 2009-07-29 2011-02-03 3R Valo, S.E.C. Anticancer agents based on amino acid derivatives
WO2011078782A1 (en) * 2009-12-22 2011-06-30 Oncopeptides Ab A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer
HUE037863T2 (hu) 2011-04-28 2018-09-28 Oncopeptides Ab Citotoxikus dipeptidek liofilizált készítménye
PT3228319T (pt) * 2011-04-28 2020-08-27 Oncopeptides Ab Preparação liofilizada de dipéptidos citotóxicos
RS60068B1 (sr) * 2012-10-26 2020-05-29 Oncopeptides Ab Liofilisani preparati melfalan flufenamida
DK2928463T3 (da) * 2012-10-26 2020-02-24 Oncopeptides Ab Lyofiliserede præparater af melphalan-flufenamid
GB201507903D0 (en) 2015-05-08 2015-06-24 Oncopeptides Ab Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en) 2015-12-01 2016-01-13 Oncopeptides Ab Dosage regimens
CN108864251B (zh) * 2018-06-30 2022-06-14 大连理工大学 一类氨肽酶n激活的药物前体化合物及其制备方法和应用
HUE061801T2 (hu) 2018-10-18 2023-08-28 Oncopeptides Ab Deutérium-tartalmú vegyületek
US12396975B2 (en) 2019-04-03 2025-08-26 Oncopeptides Ab Treatment of al amyloidosis with melflufen
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
WO2022167087A1 (en) * 2021-02-05 2022-08-11 Oncopeptides Ab Peptidase enhanced cytotoxic dipeptides
EP4083052A1 (en) 2021-04-29 2022-11-02 BKmdcl AB Peptide conjugates of melphalan for the treatment of cancer
EP4347615B1 (en) 2021-06-01 2025-05-21 Synthon B.V. Process for making melflufen or a salt thereof
GB202109896D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109894D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109895D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
EP4366721A1 (en) 2021-07-08 2024-05-15 Oncopeptides Innovation AB Melflufen for use in the treatment of multiple myeloma
GB202204171D0 (en) 2022-03-24 2022-05-11 Oncopeptides Ab Novel formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB750155A (en) 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines

Also Published As

Publication number Publication date
AU2001264515A1 (en) 2001-12-24
CA2408501A1 (en) 2001-12-20
CA2408501C (en) 2011-01-18
JP4798930B2 (ja) 2011-10-19
EP1290011B1 (en) 2010-02-24
SE0002202D0 (sv) 2000-06-13
JP2004503564A (ja) 2004-02-05
WO2001096367A1 (en) 2001-12-20
EP1290011A1 (en) 2003-03-12
ES2341702T3 (es) 2010-06-25
PT1290011E (pt) 2010-05-11
ATE458746T1 (de) 2010-03-15

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