DK1278761T3 - Modulering af oligonukleotid CpG-medieret immunstimulering ved hjælp af positionsmodificering af nukleosider - Google Patents

Modulering af oligonukleotid CpG-medieret immunstimulering ved hjælp af positionsmodificering af nukleosider

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Publication number
DK1278761T3
DK1278761T3 DK01930870T DK01930870T DK1278761T3 DK 1278761 T3 DK1278761 T3 DK 1278761T3 DK 01930870 T DK01930870 T DK 01930870T DK 01930870 T DK01930870 T DK 01930870T DK 1278761 T3 DK1278761 T3 DK 1278761T3
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Prior art keywords
nucleosides
modulation
mediated immune
immune stimulation
position modification
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DK01930870T
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Danish (da)
English (en)
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Sudhir Agrawal
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Hybridon Inc
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Publication of DK1278761T3 publication Critical patent/DK1278761T3/da

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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DK01930870T 2000-05-01 2001-04-30 Modulering af oligonukleotid CpG-medieret immunstimulering ved hjælp af positionsmodificering af nukleosider DK1278761T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20157800P 2000-05-01 2000-05-01
PCT/US2001/013682 WO2001083503A2 (en) 2000-05-01 2001-04-30 MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES

Publications (1)

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DK1278761T3 true DK1278761T3 (da) 2005-08-08

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Country Link
US (3) US7115579B2 (es)
EP (1) EP1278761B1 (es)
JP (1) JP2003531915A (es)
KR (1) KR100875003B1 (es)
AT (1) ATE292638T1 (es)
AU (2) AU5736601A (es)
CA (1) CA2407942A1 (es)
DE (1) DE60109916T2 (es)
DK (1) DK1278761T3 (es)
ES (1) ES2238044T3 (es)
PT (1) PT1278761E (es)
WO (1) WO2001083503A2 (es)

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DE60109916T2 (de) 2006-01-19
PT1278761E (pt) 2005-08-31
ES2238044T3 (es) 2005-08-16
US20060142556A1 (en) 2006-06-29
DE60109916D1 (de) 2005-05-12
US7115579B2 (en) 2006-10-03
ATE292638T1 (de) 2005-04-15
EP1278761B1 (en) 2005-04-06
EP1278761A2 (en) 2003-01-29
JP2003531915A (ja) 2003-10-28
CA2407942A1 (en) 2001-11-08
AU2001257366B2 (en) 2006-03-16
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