DK125650B - Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepin eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepin eller syreadditionssalte deraf.

Info

Publication number
DK125650B
DK125650B DK51272AA DK51272A DK125650B DK 125650 B DK125650 B DK 125650B DK 51272A A DK51272A A DK 51272AA DK 51272 A DK51272 A DK 51272A DK 125650 B DK125650 B DK 125650B
Authority
DK
Denmark
Prior art keywords
benzodiazepine
dimethoxyphenyl
dimethoxy
ethyl
methyl
Prior art date
Application number
DK51272AA
Other languages
English (en)
Inventor
J Koeroesi
T Lang
E Komlos
L Erdelyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of DK125650B publication Critical patent/DK125650B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK51272AA 1966-12-09 1972-02-04 Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepin eller syreadditionssalte deraf. DK125650B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGO001000 1966-12-09

Publications (1)

Publication Number Publication Date
DK125650B true DK125650B (da) 1973-03-19

Family

ID=10996660

Family Applications (2)

Application Number Title Priority Date Filing Date
DK611467AA DK118660B (da) 1966-12-09 1967-12-06 Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
DK51272AA DK125650B (da) 1966-12-09 1972-02-04 Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepin eller syreadditionssalte deraf.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK611467AA DK118660B (da) 1966-12-09 1967-12-06 Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.

Country Status (9)

Country Link
US (1) US3736315A (da)
AT (3) AT278797B (da)
BE (1) BE707730A (da)
CH (1) CH519507A (da)
DE (1) DE1670642C3 (da)
DK (2) DK118660B (da)
FR (1) FR6852M (da)
NL (1) NL142677B (da)
SE (1) SE324154B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30014E (en) * 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
NZ511744A (en) * 1998-10-27 2004-04-30 Vela Pharmaceuticals Inc Use of optically pure (R)-tofisopam for treating and preventing anxiety disorders and composition thereof
US6080736A (en) * 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
FR2824065A1 (fr) * 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
CA2525273C (en) * 2003-05-16 2012-04-17 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20050288277A1 (en) * 2004-06-25 2005-12-29 Kucharik Robert F Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S)-2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
FR2870539B1 (fr) * 2004-05-19 2006-08-04 Greenpharma Sa Sa Nouvelles methodes et medicaments
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
CN107915688A (zh) * 2016-10-09 2018-04-17 北京阜康仁生物制药科技有限公司 一种托非索泮的合成工艺改进方法

Also Published As

Publication number Publication date
DE1670642C3 (de) 1979-05-03
SE324154B (da) 1970-05-25
DE1670642A1 (de) 1971-03-18
AT278797B (de) 1970-02-10
FR6852M (da) 1969-04-08
BE707730A (da) 1968-04-16
NL142677B (nl) 1974-07-15
AT279618B (de) 1970-03-10
DE1670642B2 (de) 1978-09-07
US3736315A (en) 1973-05-29
DK118660B (da) 1970-09-21
NL6716753A (da) 1968-06-10
AT279617B (de) 1970-03-10
CH519507A (de) 1972-02-29

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