DK1255826T3 - Automatisering af proteindesign for proteinbiblioteker - Google Patents

Automatisering af proteindesign for proteinbiblioteker

Info

Publication number
DK1255826T3
DK1255826T3 DK01925092T DK01925092T DK1255826T3 DK 1255826 T3 DK1255826 T3 DK 1255826T3 DK 01925092 T DK01925092 T DK 01925092T DK 01925092 T DK01925092 T DK 01925092T DK 1255826 T3 DK1255826 T3 DK 1255826T3
Authority
DK
Denmark
Prior art keywords
protein
libraries
automation
design
protein design
Prior art date
Application number
DK01925092T
Other languages
Danish (da)
English (en)
Inventor
Robert J Hayes
Klaus M Fiebig
Joeerg Bentzien
Bassil I Dahiyat
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Application granted granted Critical
Publication of DK1255826T3 publication Critical patent/DK1255826T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK01925092T 2000-02-10 2001-02-12 Automatisering af proteindesign for proteinbiblioteker DK1255826T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18163000P 2000-02-10 2000-02-10
US18690400P 2000-03-03 2000-03-03
US19785100P 2000-04-14 2000-04-14

Publications (1)

Publication Number Publication Date
DK1255826T3 true DK1255826T3 (da) 2006-01-30

Family

ID=27391439

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01925092T DK1255826T3 (da) 2000-02-10 2001-02-12 Automatisering af proteindesign for proteinbiblioteker

Country Status (8)

Country Link
EP (1) EP1255826B1 (fr)
JP (1) JP2003521933A (fr)
AT (1) ATE304592T1 (fr)
AU (1) AU5168701A (fr)
CA (1) CA2399839A1 (fr)
DE (1) DE60113381T2 (fr)
DK (1) DK1255826T3 (fr)
WO (1) WO2001059066A2 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751331B2 (en) 1997-04-11 2002-08-15 California Institute Of Technology Apparatus and method for automated protein design
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US6946265B1 (en) 1999-05-12 2005-09-20 Xencor, Inc. Nucleic acids and proteins with growth hormone activity
US7687461B2 (en) 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US7351690B2 (en) 2000-12-19 2008-04-01 Palatin Technologies, Inc. Knockout identification of target-specific sites in peptides
EP1507852A4 (fr) 2001-05-04 2005-12-28 Xencor Inc Acides nucleiques et proteines presentant une activite de thioredoxine reductase
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US8093357B2 (en) 2002-03-01 2012-01-10 Xencor, Inc. Optimized Fc variants and methods for their generation
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
DK1493027T3 (en) * 2002-03-01 2014-11-17 Codexis Mayflower Holdings Llc Methods, systems and software for identifying functional biomolecules
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
JP2005529158A (ja) * 2002-05-28 2005-09-29 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 両親媒性ポリマーのコンピュータ分析および設計のための方法、システムおよびコンピュータプログラム製品
DE10233047A1 (de) * 2002-07-19 2004-02-26 Amaxa Gmbh Verfahren zur Herstellung eines künstlichen Polypeptids und nach diesem Verfahren hergestelltes künstliches Protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US7642340B2 (en) 2003-03-31 2010-01-05 Xencor, Inc. PEGylated TNF-α variant proteins
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
EP1610825A2 (fr) 2003-03-31 2006-01-04 Xencor, Inc. Procedes de pegylation rationnelle de proteines
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
EP1697741A4 (fr) 2003-12-04 2008-02-13 Xencor Inc Procedes pour produire des proteines variantes presentant une plus grande concentration en chaine hote et compositions de celles-ci
US20150010550A1 (en) 2004-07-15 2015-01-08 Xencor, Inc. OPTIMIZED Fc VARIANTS
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
AU2005304624B2 (en) 2004-11-12 2010-10-07 Xencor, Inc. Fc variants with altered binding to FcRn
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US20090054252A1 (en) * 2005-01-03 2009-02-26 Martin Lanzendoerfer Hemopexin-Like Structure as New Polypeptide-Scaffold
DK1931709T3 (en) 2005-10-03 2017-03-13 Xencor Inc FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
EP1951757B1 (fr) 2005-10-06 2014-05-14 Xencor, Inc. Anticorps anti-cd30 optimises
PL2059536T3 (pl) 2006-08-14 2014-07-31 Xencor Inc Zoptymalizowane przeciwciała ukierunkowane na CD19
CA2660795C (fr) 2006-09-18 2014-11-18 Xencor, Inc. Anticorps optimises ciblant l'antigene hm1.24
WO2009008908A2 (fr) 2007-02-12 2009-01-15 Codexis, Inc. Relations structure-activité
AU2008260498B2 (en) 2007-05-30 2012-11-29 Xencor, Inc. Methods and compositions for inhibiting CD32b expressing cells
US8633139B2 (en) 2007-12-21 2014-01-21 Abbvie Biotherapeutics Inc. Methods of screening complex protein libraries to identify altered properties
EP4269443A3 (fr) 2007-12-26 2023-12-27 Xencor, Inc. Variants fc avec liaison altérée à fcrn
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
AU2010298238A1 (en) * 2009-09-25 2012-04-26 Origene Technologies, Inc. Protein arrays and uses thereof
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
ES2963807T3 (es) 2016-06-08 2024-04-02 Xencor Inc Tratamiento de enfermedades relacionadas con la IgG4 con anticuerpos anti-CD19 de reticulación a CD32B

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
GB9701425D0 (en) * 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
AU751331B2 (en) * 1997-04-11 2002-08-15 California Institute Of Technology Apparatus and method for automated protein design
AU8886798A (en) * 1997-08-28 1999-03-22 Isao Karube Method for detecting highly functional polypeptides or nucleic acids
JP2003527072A (ja) * 1998-10-16 2003-09-16 ゼンコー 蛋白質ライブラリーに関する蛋白質設計オートメーション

Also Published As

Publication number Publication date
WO2001059066A3 (fr) 2002-04-11
ATE304592T1 (de) 2005-09-15
CA2399839A1 (fr) 2001-08-16
JP2003521933A (ja) 2003-07-22
AU5168701A (en) 2001-08-20
WO2001059066A2 (fr) 2001-08-16
EP1255826A2 (fr) 2002-11-13
EP1255826B1 (fr) 2005-09-14
DE60113381T2 (de) 2006-06-29
DE60113381D1 (de) 2005-10-20

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