DK1230238T3 - Fremgangsmåde til fremstillingen af fumagillin - Google Patents
Fremgangsmåde til fremstillingen af fumagillinInfo
- Publication number
- DK1230238T3 DK1230238T3 DK00938947T DK00938947T DK1230238T3 DK 1230238 T3 DK1230238 T3 DK 1230238T3 DK 00938947 T DK00938947 T DK 00938947T DK 00938947 T DK00938947 T DK 00938947T DK 1230238 T3 DK1230238 T3 DK 1230238T3
- Authority
- DK
- Denmark
- Prior art keywords
- fumagillin
- preparation
- salt
- liberation
- organic acid
- Prior art date
Links
- NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 title abstract 2
- NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 title abstract 2
- 229960000936 fumagillin Drugs 0.000 title abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- OLRILZDTQKZQIG-PNLOCOOESA-N n-cyclohexylcyclohexanamine;(2e,4e,6e,8e)-10-[[(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid Chemical compound C1CCCCC1NC1CCCCC1.C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 OLRILZDTQKZQIG-PNLOCOOESA-N 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9901943A HUP9901943A2 (hu) | 1999-06-11 | 1999-06-11 | Eljárás fumagillin előállítására |
| PCT/HU2000/000054 WO2000076994A2 (en) | 1999-06-11 | 2000-06-06 | Process for the preparation of fumagillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1230238T3 true DK1230238T3 (da) | 2007-08-13 |
Family
ID=89998483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00938947T DK1230238T3 (da) | 1999-06-11 | 2000-06-06 | Fremgangsmåde til fremstillingen af fumagillin |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6521764B1 (el) |
| EP (1) | EP1230238B1 (el) |
| JP (1) | JP3923798B2 (el) |
| AT (1) | ATE361292T1 (el) |
| AU (1) | AU5416600A (el) |
| CA (1) | CA2374639C (el) |
| CY (1) | CY1106728T1 (el) |
| DE (1) | DE60034699T2 (el) |
| DK (1) | DK1230238T3 (el) |
| ES (1) | ES2284500T3 (el) |
| HU (2) | HUP9901943A2 (el) |
| PT (1) | PT1230238E (el) |
| WO (1) | WO2000076994A2 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0820229A2 (pt) * | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| CN105622593B (zh) * | 2016-02-25 | 2018-06-26 | 中国农业科学院蜜蜂研究所 | 一种烟曲霉素的提取方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE36735C (de) | L. ET1ENNE in Paris, 99 Avenue Parmentier | Rohrverbindung | ||
| DD36735A (el) * | ||||
| AT193076B (de) | 1953-12-17 | 1957-11-25 | Abbott Lab | Verfahren zur Herstellung von neuen Salzen des Fumagillins |
| AT281289B (de) | 1968-01-17 | 1970-05-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung eines neuen Fumagillinsalzes |
| US5328930A (en) | 1993-03-01 | 1994-07-12 | Emory University | Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin |
-
1999
- 1999-06-11 HU HU9901943A patent/HUP9901943A2/hu unknown
-
2000
- 2000-06-06 CA CA002374639A patent/CA2374639C/en not_active Expired - Fee Related
- 2000-06-06 DK DK00938947T patent/DK1230238T3/da active
- 2000-06-06 HU HU0201574A patent/HU227695B1/hu unknown
- 2000-06-06 AT AT00938947T patent/ATE361292T1/de active
- 2000-06-06 DE DE60034699T patent/DE60034699T2/de not_active Expired - Lifetime
- 2000-06-06 US US10/009,116 patent/US6521764B1/en not_active Expired - Lifetime
- 2000-06-06 PT PT00938947T patent/PT1230238E/pt unknown
- 2000-06-06 ES ES00938947T patent/ES2284500T3/es not_active Expired - Lifetime
- 2000-06-06 AU AU54166/00A patent/AU5416600A/en not_active Abandoned
- 2000-06-06 WO PCT/HU2000/000054 patent/WO2000076994A2/en active IP Right Grant
- 2000-06-06 EP EP00938947A patent/EP1230238B1/en not_active Expired - Lifetime
- 2000-06-06 JP JP2001503852A patent/JP3923798B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-13 CY CY20071100934T patent/CY1106728T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6521764B1 (en) | 2003-02-18 |
| CA2374639C (en) | 2008-07-15 |
| AU5416600A (en) | 2001-01-02 |
| WO2000076994A2 (en) | 2000-12-21 |
| HU9901943D0 (en) | 1999-08-30 |
| EP1230238A2 (en) | 2002-08-14 |
| DE60034699D1 (de) | 2007-06-14 |
| ES2284500T3 (es) | 2007-11-16 |
| JP2003502324A (ja) | 2003-01-21 |
| CY1106728T1 (el) | 2012-05-23 |
| CA2374639A1 (en) | 2000-12-21 |
| DE60034699T2 (de) | 2008-01-17 |
| ATE361292T1 (de) | 2007-05-15 |
| PT1230238E (pt) | 2007-06-22 |
| JP3923798B2 (ja) | 2007-06-06 |
| WO2000076994A3 (en) | 2001-02-08 |
| HUP0201574A3 (en) | 2003-08-28 |
| HUP0201574A2 (en) | 2002-08-28 |
| HU227695B1 (en) | 2011-12-28 |
| HUP9901943A2 (hu) | 2001-12-28 |
| EP1230238B1 (en) | 2007-05-02 |
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