DK121082B - Analogifremgangsmåde til fremstilling af 6α-fluor-9α, 11β-dihalogen-16α-methyl-1,4-pregnadien-21-ol-3,20-dioner eller estere heraf. - Google Patents

Analogifremgangsmåde til fremstilling af 6α-fluor-9α, 11β-dihalogen-16α-methyl-1,4-pregnadien-21-ol-3,20-dioner eller estere heraf.

Info

Publication number
DK121082B
DK121082B DK386468AA DK386468A DK121082B DK 121082 B DK121082 B DK 121082B DK 386468A A DK386468A A DK 386468AA DK 386468 A DK386468 A DK 386468A DK 121082 B DK121082 B DK 121082B
Authority
DK
Denmark
Prior art keywords
pregnadien
dihalogen
diones
fluoro
esters
Prior art date
Application number
DK386468AA
Other languages
Danish (da)
English (en)
Inventor
H Laurent
R Wiechert
E Gerhards
U Kerb
K Kolb
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK121082B publication Critical patent/DK121082B/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DK386468AA 1967-08-16 1968-08-09 Analogifremgangsmåde til fremstilling af 6α-fluor-9α, 11β-dihalogen-16α-methyl-1,4-pregnadien-21-ol-3,20-dioner eller estere heraf. DK121082B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1967SC041166 DE1643036B2 (de) 1967-08-16 1967-08-16 Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK121082B true DK121082B (da) 1971-09-06

Family

ID=7436074

Family Applications (1)

Application Number Title Priority Date Filing Date
DK386468AA DK121082B (da) 1967-08-16 1968-08-09 Analogifremgangsmåde til fremstilling af 6α-fluor-9α, 11β-dihalogen-16α-methyl-1,4-pregnadien-21-ol-3,20-dioner eller estere heraf.

Country Status (13)

Country Link
US (2) US3609171A (xx)
AT (1) AT280501B (xx)
BE (1) BE719577A (xx)
CS (1) CS166686B2 (xx)
DE (1) DE1643036B2 (xx)
DK (1) DK121082B (xx)
ES (1) ES357225A1 (xx)
FI (1) FI45444C (xx)
FR (2) FR1601117A (xx)
GB (1) GB1240719A (xx)
IE (1) IE32269B1 (xx)
NL (1) NL161766C (xx)
SE (1) SE339827B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643036B2 (de) * 1967-08-16 1976-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US3933799A (en) * 1969-01-29 1976-01-20 Glaxo Laboratories Limited 11β-Halo-9,12-unsubstituted-C19 -steroids
DE2064859C3 (de) * 1970-12-30 1980-05-22 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 6 a -Fluor-16 a , 18dimethyl-l,4-pregnadien-3,20-dion Derivate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US5707984A (en) * 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3426128A (en) * 1961-02-22 1969-02-04 Schering Ag Delta**1,4-16alpha-methyl steroids
US3415855A (en) * 1966-05-27 1968-12-10 Schering Corp Trichloro pregnadienes and esters thereof
US3422193A (en) * 1966-08-11 1969-01-14 Schering Corp 17-mono esters of corticoids
DE1643036B2 (de) * 1967-08-16 1976-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US3501513A (en) * 1968-02-29 1970-03-17 Syntex Corp Preparation of 17-desoxy steroids from corresponding 17alpha,21-dihydroxy - 20 - oxo steroids and 21-esters thereof

Also Published As

Publication number Publication date
NL6811753A (xx) 1969-02-18
AT280501B (de) 1970-04-10
NL161766B (nl) 1979-10-15
DE1643036B2 (de) 1976-04-15
CS166686B2 (xx) 1976-03-29
ES357225A1 (es) 1970-03-01
IE32269B1 (en) 1973-05-30
IE32269L (en) 1969-02-16
GB1240719A (en) 1971-07-28
FR1601117A (xx) 1970-08-10
DE1643036A1 (de) 1971-04-15
NL161766C (nl) 1980-03-17
US3743741A (en) 1973-07-03
US3609171A (en) 1971-09-28
FI45444C (fi) 1972-06-12
SE339827B (xx) 1971-10-25
FR8096M (xx) 1970-07-20
FI45444B (xx) 1972-02-29
BE719577A (xx) 1969-02-17

Similar Documents

Publication Publication Date Title
DK137232B (da) Analogifremgangsmåde til fremstilling af phenylethanolaminer.
DK120698B (da) Analogifremgangsmåde til fremstilling af acetylguanidiner.
DK127853B (da) Analogifremgangsmåde til fremstilling af benzodipyroner.
DK121082B (da) Analogifremgangsmåde til fremstilling af 6α-fluor-9α, 11β-dihalogen-16α-methyl-1,4-pregnadien-21-ol-3,20-dioner eller estere heraf.
DK120489B (da) Analogifremgangsmåde til fremstilling af 17α-alkenyl- eller -alkynyl-11,13β-dialkylgon-4-en-3,17β-dioler eller estere deraf.
DK122882B (da) Fremgangsmåde til fremstilling af kawain eller methysticin.
DK124882B (da) Analogifremgangsmåde til fremstilling af 17α-acyloxy-11β-methyl-19-norpregn-4-en-3,20-dioner.
DK113585B (da) Analogifremgangsmåde til fremstilling af 15, 16β-methylen-3-keto-Δ<4>-19-nor-androsten-17β-oler eller estere deraf.
DK119976B (da) Analogifremgangsmåde til fremstilling af 18-methyl-19-nor-17α-hydroxyprogesteroner og -17-estere deraf.
DK121227B (da) Analogifremgangsmåde til fremstilling af 6α,9α-difluorhydrocortison- eller prednisolon-17-valerat.
DK131820B (da) Analogifremgangsmåde til fremstilling af 4-aminoquinazoliner eller 1-aminoisoquinoliner.
DK121372B (da) Analogifremgangsmåde til fremstilling af 17β-(1-alkoxycycloalkyloxy)-2α,3α-epithio-5α-androstaner.
DK129836B (da) Analogifremgangsmåde til fremstilling af 21-fluor-3β-hydroxy-pregna-5,16-dien-20-on eller estere deraf.
DK129990B (da) Analogifremgangsmåde til fremstilling af 3-oxo-13β-alkyl-17α-methyl-20?-hydroxy-18,19-di-nor-pregna-4,9-diener eller estere deraf.
DK128456B (da) Analogifremgangsmåde til fremstilling af ketonreduceret dihydrotyløsin eller ketonreduceret dihydrodesmycosin.
DK126649B (da) Analogifremgangsmåde til fremstilling af 18-methylensteroider af pregnan- eller 19-nor-pregnanrækken.
DK120744B (da) Fremgangsmåde til fremstilling af steroidbutenolider.
DK121165B (da) Fremgangsmåde til fremstilling af 1-aminoalkyl-1-arylindenar eller 3-aminoalkyl-3-arylindan-1-oler.
DK126036B (da) Analogifremgangsmåde til frmstilling af 3-oxo-13β-ethyl-7α, 17α-dimethyl-17β-hydroxy-4,9,11-gonatrien eller estere deraf.
DK117568B (da) Analogifremgangsmåde til fremstilling af ftalazino-ftalazindioner.
DK122666B (da) Analogifremgangsmåde til fremstilling af hydrocortison-17-cyclopentancorboxylat.
DK116208B (da) Analogifremgangsmåde til fremstilling af 17-hydroxy- eller 17-acyloxy-6β, 7β-epoxy-1α, 2α-methylen-4-pregnen-3,20-dioner.
DK122451B (da) Analogifremgangsmåde til fremstilling af 7α-methyl-1α,2α-methylenandrost-4-en-17β-ol-3-on eller estere deraf.
DK122606B (da) Analogifremgangsmåde til fremstilling af 4-chlor-6-halogen-Δ<4,6>-pregnadien-20-on-3β-oler eller estere deraf.
DK118402B (da) Analogifremgangsmåde til fremstilling af 11β-hydroxy-pregn-4-en-3,20-dion-[17α,16α-d]-oxazoliner.