DK1105360T3 - Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler - Google Patents

Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler

Info

Publication number
DK1105360T3
DK1105360T3 DK99948042T DK99948042T DK1105360T3 DK 1105360 T3 DK1105360 T3 DK 1105360T3 DK 99948042 T DK99948042 T DK 99948042T DK 99948042 T DK99948042 T DK 99948042T DK 1105360 T3 DK1105360 T3 DK 1105360T3
Authority
DK
Denmark
Prior art keywords
compound
protein
fusion
nucleic acid
libraries
Prior art date
Application number
DK99948042T
Other languages
Danish (da)
English (en)
Inventor
Peter Lohse
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1105360T3 publication Critical patent/DK1105360T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK99948042T 1998-08-17 1999-08-16 Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler DK1105360T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9682098P 1998-08-17 1998-08-17
PCT/US1999/018600 WO2000009464A1 (en) 1998-08-17 1999-08-16 Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules

Publications (1)

Publication Number Publication Date
DK1105360T3 true DK1105360T3 (da) 2009-11-02

Family

ID=22259237

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99948042T DK1105360T3 (da) 1998-08-17 1999-08-16 Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler

Country Status (12)

Country Link
US (1) US6602685B1 (el)
EP (1) EP1105360B1 (el)
JP (1) JP4278872B2 (el)
AT (1) ATE437844T1 (el)
AU (1) AU757955B2 (el)
CA (1) CA2337490C (el)
CY (1) CY1110515T1 (el)
DE (1) DE69941193D1 (el)
DK (1) DK1105360T3 (el)
ES (1) ES2329205T3 (el)
PT (1) PT1105360E (el)
WO (1) WO2000009464A1 (el)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US6436665B1 (en) * 1999-08-27 2002-08-20 Phylos, Inc Methods for encoding and sorting in vitro translated proteins
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
ATE322558T1 (de) 2000-01-24 2006-04-15 Compound Therapeutics Inc Sensible und multiplexe diagnostische tests zur proteinanalyse
GB2360282A (en) * 2000-03-17 2001-09-19 Bioinvent Int Ab Making and using micro-arrays of biological materials
US6962781B1 (en) * 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US6539102B1 (en) 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
US6980674B2 (en) 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
WO2003029490A1 (en) * 2001-10-01 2003-04-10 Yingjian Wang Methods and arrays for detecting biological molecules
US7125669B2 (en) * 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
AU2003267951A1 (en) * 2002-04-26 2003-12-19 Genencor International, Inc. Methods and articles for high throughput analysis of biomolecular interactions
JPWO2003097862A1 (ja) * 2002-05-17 2005-09-15 協和醗酵工業株式会社 抗糖尿病作用を有する物質の探索方法
WO2004010106A2 (en) 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
US20040142379A1 (en) * 2003-01-16 2004-07-22 Carlsberg Research Laboratory Affinity fishing for ligands and proteins receptors
KR101337320B1 (ko) * 2003-11-20 2013-12-06 사노피 파스퇴르 인크 백일해 독소의 정제방법 및 이에 유용한 펩타이드
AU2006295515A1 (en) * 2005-09-27 2007-04-05 Polybatics Limited Polymer particles and uses thereof
PT2339014E (pt) 2005-11-16 2015-10-13 Ambrx Inc Métodos e composições compreendendo aminoácidos não-naturais
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
WO2009009186A2 (en) * 2007-04-13 2009-01-15 The Regents Of The University Of California Receptors useful for gas phase chemical sensing
US7678883B2 (en) 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
CA2904458C (en) 2007-11-30 2017-07-25 Wolfgang Fraunhofer Protein formulations and methods of making same
WO2010011944A2 (en) 2008-07-25 2010-01-28 Wagner Richard W Protein screeing methods
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100247590A1 (en) * 2009-03-30 2010-09-30 Johnson & Johnson Peptide-Based Systems For Delivery Of Cosmetic Agents
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
WO2011098449A1 (en) 2010-02-10 2011-08-18 Novartis Ag Methods and compounds for muscle growth
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
EP3798236B1 (en) 2011-03-15 2022-08-10 X-Body, Inc. Antibody screening methods
AU2012230880B2 (en) * 2011-03-24 2017-04-13 Opko Pharmaceuticals, Llc Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics
ES2861595T3 (es) 2011-04-28 2021-10-06 Univ Leland Stanford Junior Identificación de polinucleótidos asociados a una muestra
EP3712173B1 (en) 2011-12-05 2023-07-12 X-Body, Inc. Pdgf receptor beta binding polypeptides
WO2014145458A1 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents On Behalf Of Arizona State University Nucleic acid-tagged compositions and methods for multiplexed protein-protein interaction profiling
EP3739336B1 (en) 2013-06-28 2022-05-11 X-Body, Inc. Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
CN110058023B (zh) 2013-09-23 2022-10-14 X博迪公司 用于生成对抗细胞表面抗原的结合剂的方法和组合物
EP3102245B1 (en) 2014-02-05 2021-09-08 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361943B1 (en) 1996-10-17 2002-03-26 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4587044A (en) 1983-09-01 1986-05-06 The Johns Hopkins University Linkage of proteins to nucleic acids
JP2584613B2 (ja) 1985-03-30 1997-02-26 バリベ、マール 組換えｄｎａ技術によってｄｎａ、ｒｎａ、ペプタイド、ポリペプタイド、または蛋白質を取得するための方法
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
EP0494955B1 (en) 1989-10-05 1998-07-15 Optein, Inc. Cell-free synthesis and isolation of novel genes and polypeptides
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
DE4112440C1 (el) 1991-04-16 1992-10-22 Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De
US5795747A (en) 1991-04-16 1998-08-18 Evotec Biosystems Gmbh Process for manufacturing new biopolymers
AU2313392A (en) 1991-08-01 1993-03-02 University Research Corporation Systematic polypeptide evolution by reverse translation
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE69534347T2 (de) 1994-01-31 2006-05-24 Trustees Of Boston University, Boston Bibliotheken aus Polyklonalen Antikörpern
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
EP0763202A4 (en) 1994-05-23 1998-12-09 Smithkline Beecham Corp ENCODED COMBINATORIAL LIBRARIES
US5627024A (en) 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
US5559000A (en) 1995-01-18 1996-09-24 The Scripps Research Institute Encoded reaction cassette
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5872015A (en) * 1996-05-10 1999-02-16 Board Of Trustees Of The University Of Illinois Molecular diversity screening method
US5962645A (en) * 1996-10-04 1999-10-05 University Of Maryland Antiproliferative factor from patients with interstitial cystitis
ATE332368T1 (de) * 1997-01-21 2006-07-15 Gen Hospital Corp Selektion von proteinen mittels rns-protein fusionen
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
GB9712512D0 (en) 1997-06-16 1997-08-20 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US5985575A (en) 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function

Also Published As

Publication number Publication date
EP1105360B1 (en) 2009-07-29
EP1105360A1 (en) 2001-06-13
PT1105360E (pt) 2009-09-30
EP1105360A4 (en) 2005-06-22
WO2000009464A1 (en) 2000-02-24
ES2329205T3 (es) 2009-11-23
CA2337490A1 (en) 2000-02-24
US6602685B1 (en) 2003-08-05
AU757955B2 (en) 2003-03-13
CA2337490C (en) 2012-01-03
AU6129699A (en) 2000-03-06
ATE437844T1 (de) 2009-08-15
JP4278872B2 (ja) 2009-06-17
WO2000009464A9 (en) 2000-09-28
DE69941193D1 (de) 2009-09-10
CY1110515T1 (el) 2015-04-29
JP2002522057A (ja) 2002-07-23

Similar Documents

Publication Publication Date Title
DK1105360T3 (da) Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler
Mikkelsen et al. Bioanalytical chemistry
Johannsson et al. A fast highly sensitive colorimetric enzyme immunoassay system demonstrating benefits of enzyme amplification in clinical chemistry
DE60118527D1 (de) Sensible und multiplexe diagnostische tests zur proteinanalyse
DE69700902D1 (de) Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
DE60135912D1 (de) Nachweis der hybridisierung von nukleinsäuren durch fluoreszenzpolarisation
Meyer et al. Orthogonal protein decoration of DNA nanostructures
CY1109246T1 (el) Μεθοδος ανιχνευσης συνδετη
WO2001027624A3 (en) Compositions and methods for detecting protein modification and enzymatic activity
DK1252328T3 (da) Fremgangsmåde og midler til isolering af mikroorganismer
WO2000015850A1 (en) Assays for measuring nucleic acid binding proteins and enzyme activities
RU2004126254A (ru) Анализ активности киназы actriib
WO2004099441A3 (en) Selection and evolution of chemical libraries
Sheng et al. A nanopore sensing assay resolves cascade reactions in a multienzyme system
Shi et al. Polymerase-extension-based selection method for DNA-encoded chemical libraries against nonimmobilized protein targets
Zee et al. Suppl 1: Quantitative Proteomic Approaches to Studying Histone Modifications
Li et al. Targeted quantification of functional enzyme dynamics in environmental samples for microbially mediated biogeochemical processes
Visser et al. Surface‐Plasmon‐Resonance‐Based Chemical Proteomics: Efficient Specific Extraction and Semiquantitative Identification of Cyclic Nucleotide‐Binding Proteins from Cellular Lysates by Using a Combination of Surface Plasmon Resonance, Sequential Elution and Liquid Chromatography–Tandem Mass Spectrometry
Kuropka et al. Sortase A mediated site‐specific immobilization for identification of protein interactions in affinity purification–mass spectrometry experiments
Gramatikova et al. Pyridoxal 5′-phosphate-dependent catalytic antibody
EP1117841A4 (en) METHOD FOR DETECTING COMPOUNDS THAT INFLUENCE THE INTERACTION OF RNA AND RNA-BINDING PROTEINS
WO2003002752A3 (en) Methods of using nick translate libraries for snp analysis
Fan et al. Development of a capillary electrophoresis‐based assay of sirtuin enzymes
DK0774116T3 (da) Fremgangsmåde til screening af biblioteker af forbindelser
Gramatikova et al. Monoclonal Antibodies against Nα-(5′-Phosphopyridoxyl)-L-lysine: SCREENING AND SPECTRUM OF PYRIDOXAL 5′-PHOSPHATE-DEPENDENT ACTIVITIES TOWARD AMINO ACIDS