DK1100912T3 - Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet - Google Patents

Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet

Info

Publication number
DK1100912T3
DK1100912T3 DK99940032T DK99940032T DK1100912T3 DK 1100912 T3 DK1100912 T3 DK 1100912T3 DK 99940032 T DK99940032 T DK 99940032T DK 99940032 T DK99940032 T DK 99940032T DK 1100912 T3 DK1100912 T3 DK 1100912T3
Authority
DK
Denmark
Prior art keywords
iii
modulators
screening
calcineurin activity
recombinant
Prior art date
Application number
DK99940032T
Other languages
Danish (da)
English (en)
Inventor
Helge Voelkel
Original Assignee
Genopia Biomedical Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genopia Biomedical Gmbh filed Critical Genopia Biomedical Gmbh
Application granted granted Critical
Publication of DK1100912T3 publication Critical patent/DK1100912T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Interface Circuits In Exchanges (AREA)
  • Burglar Alarm Systems (AREA)
  • Measuring Fluid Pressure (AREA)
DK99940032T 1998-07-22 1999-07-22 Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet DK1100912T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98113876A EP0976823A1 (fr) 1998-07-22 1998-07-22 Système d'expression recombinante et essai biologique à grand débit pour l'utilisation thérapeutique de calcineurine-A-alpha, calcineurine-A-beta, calcineurine-A-gamma et Cu/Zn-superoxide dismutase respectivement pour l'identification des compositions pharmaceutiques
EP99940032A EP1100912B1 (fr) 1998-07-22 1999-07-22 Technique de criblage de modulateurs de l'activite de la calcineurine

Publications (1)

Publication Number Publication Date
DK1100912T3 true DK1100912T3 (da) 2004-11-15

Family

ID=8232338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99940032T DK1100912T3 (da) 1998-07-22 1999-07-22 Fremgangsmåde til at screene for modulatorer for calcineurin-aktivitet

Country Status (9)

Country Link
US (1) US6875581B1 (fr)
EP (2) EP0976823A1 (fr)
JP (1) JP2002522015A (fr)
AT (1) ATE270709T1 (fr)
AU (1) AU5412499A (fr)
CA (1) CA2335278A1 (fr)
DE (1) DE69918557T2 (fr)
DK (1) DK1100912T3 (fr)
WO (1) WO2000005363A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281756A1 (fr) * 2001-07-31 2003-02-05 GENOPIA Biomedical GmbH Régulateur de calcineurin
JP2005113721A (ja) * 2003-10-06 2005-04-28 Hitachi Ltd 蒸気タービン
WO2007081804A2 (fr) 2006-01-05 2007-07-19 Immune Disease Institute, Inc. Régulateurs de nfat
EP1810675A1 (fr) 2006-01-18 2007-07-25 Institut Curie Methode de traitement de la maladie de Huntington par l'inhibition de la dephosphorylation de la S421
WO2008148108A1 (fr) 2007-05-24 2008-12-04 Calcimedica, Inc. Protéines de canal de calcium et leur utilisation
JP5559049B2 (ja) * 2007-07-10 2014-07-23 チルドレンズ メディカル センター コーポレーション 間質相互作用分子ノックアウトマウス及びその使用
CA2694329A1 (fr) * 2007-08-01 2009-02-05 Emory University Procedes de determination d'une activite de proteine phosphatase et son utilisation dans la prediction de resultats therapeutiques
US20110039789A1 (en) * 2009-08-14 2011-02-17 Institut Curie Use of Huntingtin Protein for the Diagnosis and the Treatment of Cancer
US8394778B1 (en) 2009-10-08 2013-03-12 Immune Disease Institute, Inc. Regulators of NFAT and/or store-operated calcium entry
US9567580B2 (en) 2010-10-08 2017-02-14 Anjana Rao Regulators of NFAT and/or store-operated calcium entry
WO2013135352A1 (fr) 2012-03-15 2013-09-19 Merck Patent Gmbh Dispositifs électroniques
US20200256880A1 (en) * 2017-08-16 2020-08-13 The Broad Institute, Inc. Neuronal Assay Method Involving Calcineurin
EP3715406A1 (fr) 2019-03-29 2020-09-30 Henkel AG & Co. KGaA Procédé de modification de la polarité de surface de substrats de caoutchouc

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3366358B2 (ja) * 1992-12-16 2003-01-14 武田薬品工業株式会社 ヒトカルシニューリンＡαアイソフォーム蛋白質をコードするＤＮＡおよびその用途
CA2185105A1 (fr) 1994-03-10 1995-09-14 Masakazu Kobayashi Methode d'analyse d'un immunosuppresseur
US5723436A (en) * 1994-10-24 1998-03-03 The Board Of Trustees Of The Leland Stanford Junior University Calcineurin interacting protein compositions and methods
US5807693A (en) 1994-11-23 1998-09-15 Icos Corporation Calcineurin inhibitory compounds and anchoring protein
US5871945A (en) * 1994-11-23 1999-02-16 Icos Corporation Modulators of anchoring protein function
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them

Also Published As

Publication number Publication date
US6875581B1 (en) 2005-04-05
CA2335278A1 (fr) 2000-02-03
EP1100912A1 (fr) 2001-05-23
JP2002522015A (ja) 2002-07-23
DE69918557D1 (de) 2004-08-12
EP1100912B1 (fr) 2004-07-07
WO2000005363A1 (fr) 2000-02-03
ATE270709T1 (de) 2004-07-15
AU5412499A (en) 2000-02-14
DE69918557T2 (de) 2005-07-28
EP0976823A1 (fr) 2000-02-02

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