DK1097140T3 - Imidazolderivater med biphenylsubstitution, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel eller diagnostikum og lægemiddel som indeholder dem - Google Patents
Imidazolderivater med biphenylsubstitution, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel eller diagnostikum og lægemiddel som indeholder demInfo
- Publication number
- DK1097140T3 DK1097140T3 DK99934669T DK99934669T DK1097140T3 DK 1097140 T3 DK1097140 T3 DK 1097140T3 DK 99934669 T DK99934669 T DK 99934669T DK 99934669 T DK99934669 T DK 99934669T DK 1097140 T3 DK1097140 T3 DK 1097140T3
- Authority
- DK
- Denmark
- Prior art keywords
- drug
- diagnostic
- preparation
- imidazole derivatives
- biphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19832429A DE19832429A1 (de) | 1998-07-18 | 1998-07-18 | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PCT/EP1999/004886 WO2000003994A2 (fr) | 1998-07-18 | 1999-07-10 | Derives d'imidazole a substitution biphenylsulfonyle, leur procede de preparation, leur utilisation comme medicament ou agent diagnostique, ainsi que medicament les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1097140T3 true DK1097140T3 (da) | 2004-05-24 |
Family
ID=7874575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99934669T DK1097140T3 (da) | 1998-07-18 | 1999-07-10 | Imidazolderivater med biphenylsubstitution, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel eller diagnostikum og lægemiddel som indeholder dem |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6372917B1 (fr) |
| EP (1) | EP1097140B1 (fr) |
| JP (1) | JP4567884B2 (fr) |
| KR (1) | KR20010070984A (fr) |
| CN (1) | CN1177827C (fr) |
| AR (1) | AR019404A1 (fr) |
| AT (1) | ATE260901T1 (fr) |
| AU (1) | AU764784B2 (fr) |
| BR (1) | BR9912139A (fr) |
| CA (1) | CA2338039A1 (fr) |
| DE (2) | DE19832429A1 (fr) |
| DK (1) | DK1097140T3 (fr) |
| ES (1) | ES2217779T3 (fr) |
| HK (1) | HK1038352A1 (fr) |
| HU (1) | HUP0103184A3 (fr) |
| ID (1) | ID27023A (fr) |
| MX (1) | MXPA01000534A (fr) |
| PL (1) | PL346165A1 (fr) |
| PT (1) | PT1097140E (fr) |
| RU (1) | RU2246489C2 (fr) |
| TR (1) | TR200100123T2 (fr) |
| WO (1) | WO2000003994A2 (fr) |
| ZA (1) | ZA200100318B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19832428A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832429A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR20030024259A (ko) * | 2001-09-17 | 2003-03-26 | 주식회사케이텍정보통신 | 도로통행료 징수 시스템 |
| US6844361B2 (en) * | 2002-02-04 | 2005-01-18 | Aventis Pharma Deutschland Gmbh | Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor |
| DE10206354A1 (de) * | 2002-02-14 | 2003-08-28 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen |
| US20030220383A1 (en) * | 2002-02-14 | 2003-11-27 | Aventis Pharma Deutschland Gmbh | Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders |
| US7531569B2 (en) * | 2003-12-02 | 2009-05-12 | Sanofi-Aventis Deutschland Gmbh | Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives |
| DE10356717A1 (de) * | 2003-12-02 | 2005-07-07 | Aventis Pharma Deutschland Gmbh | Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten |
| WO2018002673A1 (fr) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Nouvelles formulations d'antagonistes du récepteur de l'angiotensine ii |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
| CA2058198A1 (fr) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Procede de preparation et utilisation de derives d'azole |
| EP0503838A3 (en) * | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| JP3290657B2 (ja) * | 1991-05-01 | 2002-06-10 | メルク エンド カムパニー インコーポレーテッド | アンギオテンシンｉｉ拮抗剤として活性な酸性アラルキルトリアゾール誘導体 |
| TW215434B (fr) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
| US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| FR2711367B1 (fr) | 1993-10-19 | 1995-12-01 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2711368B1 (fr) * | 1993-09-16 | 1996-01-05 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2716883B1 (fr) | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
| FR2716882B1 (fr) | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0855392A3 (fr) * | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Hétérocycles à cinq chaínons contenant des substituants biphénylylsulphoniques, leur procédé de préparation, leur utilisation comme médicament ou agent diagnostique ainsi que médicament les contenant |
| DE19832428A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832429A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1998
- 1998-07-18 DE DE19832429A patent/DE19832429A1/de not_active Withdrawn
-
1999
- 1999-07-10 KR KR1020017000751A patent/KR20010070984A/ko not_active Application Discontinuation
- 1999-07-10 AU AU50364/99A patent/AU764784B2/en not_active Ceased
- 1999-07-10 ES ES99934669T patent/ES2217779T3/es not_active Expired - Lifetime
- 1999-07-10 US US09/743,941 patent/US6372917B1/en not_active Expired - Lifetime
- 1999-07-10 CA CA002338039A patent/CA2338039A1/fr not_active Abandoned
- 1999-07-10 ID IDW20010128A patent/ID27023A/id unknown
- 1999-07-10 AT AT99934669T patent/ATE260901T1/de not_active IP Right Cessation
- 1999-07-10 BR BR9912139-5A patent/BR9912139A/pt not_active IP Right Cessation
- 1999-07-10 DE DE59908753T patent/DE59908753D1/de not_active Expired - Lifetime
- 1999-07-10 HU HU0103184A patent/HUP0103184A3/hu unknown
- 1999-07-10 PT PT99934669T patent/PT1097140E/pt unknown
- 1999-07-10 MX MXPA01000534A patent/MXPA01000534A/es not_active IP Right Cessation
- 1999-07-10 RU RU2001104454/04A patent/RU2246489C2/ru not_active IP Right Cessation
- 1999-07-10 CN CNB998086967A patent/CN1177827C/zh not_active Expired - Fee Related
- 1999-07-10 EP EP99934669A patent/EP1097140B1/fr not_active Expired - Lifetime
- 1999-07-10 DK DK99934669T patent/DK1097140T3/da active
- 1999-07-10 JP JP2000560101A patent/JP4567884B2/ja not_active Expired - Fee Related
- 1999-07-10 PL PL99346165A patent/PL346165A1/xx not_active Application Discontinuation
- 1999-07-10 WO PCT/EP1999/004886 patent/WO2000003994A2/fr not_active Application Discontinuation
- 1999-07-10 TR TR2001/00123T patent/TR200100123T2/xx unknown
- 1999-07-15 AR ARP990103485A patent/AR019404A1/es not_active Application Discontinuation
-
2001
- 2001-01-11 ZA ZA200100318A patent/ZA200100318B/en unknown
- 2001-12-27 HK HK01109111A patent/HK1038352A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE260901T1 (de) | 2004-03-15 |
| CA2338039A1 (fr) | 2000-01-27 |
| CN1177827C (zh) | 2004-12-01 |
| KR20010070984A (ko) | 2001-07-28 |
| EP1097140B1 (fr) | 2004-03-03 |
| RU2246489C2 (ru) | 2005-02-20 |
| JP4567884B2 (ja) | 2010-10-20 |
| PT1097140E (pt) | 2004-07-30 |
| AR019404A1 (es) | 2002-02-20 |
| MXPA01000534A (es) | 2002-06-04 |
| DE19832429A1 (de) | 2000-01-20 |
| ZA200100318B (en) | 2002-04-11 |
| TR200100123T2 (tr) | 2001-05-21 |
| US6372917B1 (en) | 2002-04-16 |
| WO2000003994A3 (fr) | 2000-04-20 |
| HUP0103184A2 (hu) | 2002-04-29 |
| ES2217779T3 (es) | 2004-11-01 |
| DE59908753D1 (de) | 2004-04-08 |
| AU5036499A (en) | 2000-02-07 |
| EP1097140A2 (fr) | 2001-05-09 |
| WO2000003994A2 (fr) | 2000-01-27 |
| HUP0103184A3 (en) | 2002-05-28 |
| JP2002520397A (ja) | 2002-07-09 |
| PL346165A1 (en) | 2002-01-28 |
| ID27023A (id) | 2001-02-22 |
| BR9912139A (pt) | 2001-04-10 |
| CN1309644A (zh) | 2001-08-22 |
| AU764784B2 (en) | 2003-08-28 |
| HK1038352A1 (en) | 2002-03-15 |
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