DK1089968T3 - Thyroideahormonanaloger og fremgangsmåder til deres fremstilling - Google Patents
Thyroideahormonanaloger og fremgangsmåder til deres fremstillingInfo
- Publication number
- DK1089968T3 DK1089968T3 DK99932002T DK99932002T DK1089968T3 DK 1089968 T3 DK1089968 T3 DK 1089968T3 DK 99932002 T DK99932002 T DK 99932002T DK 99932002 T DK99932002 T DK 99932002T DK 1089968 T3 DK1089968 T3 DK 1089968T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- methods
- thyroid hormone
- hormone analogues
- analogues
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9118598P | 1998-06-30 | 1998-06-30 | |
| EP99932002A EP1089968B1 (fr) | 1998-06-30 | 1999-06-28 | Analogues des hormones thyroidiennes et methodes de preparation associees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1089968T3 true DK1089968T3 (da) | 2005-08-22 |
Family
ID=22226506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99932002T DK1089968T3 (da) | 1998-06-30 | 1999-06-28 | Thyroideahormonanaloger og fremgangsmåder til deres fremstilling |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6107517A (fr) |
| EP (2) | EP1598334A1 (fr) |
| JP (1) | JP2002519340A (fr) |
| KR (1) | KR20010053277A (fr) |
| AT (1) | ATE293595T1 (fr) |
| AU (1) | AU4840199A (fr) |
| CA (1) | CA2335551C (fr) |
| DE (1) | DE69924846T2 (fr) |
| DK (1) | DK1089968T3 (fr) |
| ES (1) | ES2241294T3 (fr) |
| IL (1) | IL140140A0 (fr) |
| PT (1) | PT1089968E (fr) |
| WO (1) | WO2000000468A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
| WO2000072813A1 (fr) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Methode de traitement de la perte des cheveux a l'aide de derives de diphenylmethane |
| AU3712100A (en) | 1999-06-01 | 2000-12-18 | University Of Texas Southwestern Medical Center, The | Method of treating hair loss using sulfonyl thyromimetic compounds |
| US6723717B1 (en) | 1999-06-01 | 2004-04-20 | The University Of Texas Southwestern Medical Center | Sulfur-containing thyroxane derivatives and their use as hair growth promotors |
| US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
| US20040132830A1 (en) * | 2001-01-19 | 2004-07-08 | Finer Jeffrey T | Triphenylmethane kinesin inhibitors |
| US7302347B2 (en) * | 2002-12-10 | 2007-11-27 | The Regents Of The University Of California | Method for creating specific, high affinity nuclear receptor pharmaceuticals |
| SE526033C3 (sv) * | 2003-11-06 | 2009-12-08 | Metso Paper Inc | Silanordning och silkorg för silning av massasuspensioner |
| KR20060109926A (ko) * | 2003-11-19 | 2006-10-23 | 메타베이시스 테라퓨틱스, 인크. | 새로운 인-함유 갑상선 호르몬 모방약들 |
| MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
| WO2006128056A2 (fr) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Nouvelles substances thyromimetiques contenant de l'acide phosphinique |
| WO2007002036A1 (fr) * | 2005-06-24 | 2007-01-04 | Thomas Lavin | Hormones thyroidiennes dans les depots de brulures et adipeux |
| JP2016517883A (ja) | 2013-05-03 | 2016-06-20 | オレゴン ヘルス アンド サイエンス ユニバーシティー | Ｘ連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用 |
| KR102331596B1 (ko) | 2016-05-18 | 2021-11-25 | 오레곤 헬스 앤드 사이언스 유니버시티 | 소베티롬의 유도체 |
| JP2020500199A (ja) | 2016-11-21 | 2020-01-09 | バイキング・セラピューティクス・インコーポレイテッド | グリコーゲン蓄積症の治療方法 |
| EP3634426A4 (fr) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | Compositions pour le traitement d'une fibrose |
| US11787828B2 (en) | 2018-03-22 | 2023-10-17 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| US11827596B2 (en) | 2018-12-12 | 2023-11-28 | Autobahn Therapeutics, Inc. | Thyromimetics |
| EP3931180A1 (fr) | 2019-03-01 | 2022-01-05 | Autobahn Therapeutics, Inc. | Nouveaux thyromimétiques |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3332957A (en) * | 1964-09-02 | 1967-07-25 | Ciba Geigy Corp | Amino esters of substituted phenoxy acetic acids |
| JPS5195049A (en) * | 1975-02-12 | 1976-08-20 | * **********so*****no***tsu*****************************************ni*no | |
| US4323691A (en) * | 1979-10-09 | 1982-04-06 | Abbott Laboratories | Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters |
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
-
1999
- 1999-06-28 AT AT99932002T patent/ATE293595T1/de not_active IP Right Cessation
- 1999-06-28 EP EP05008536A patent/EP1598334A1/fr not_active Withdrawn
- 1999-06-28 ES ES99932002T patent/ES2241294T3/es not_active Expired - Lifetime
- 1999-06-28 CA CA002335551A patent/CA2335551C/fr not_active Expired - Fee Related
- 1999-06-28 EP EP99932002A patent/EP1089968B1/fr not_active Expired - Lifetime
- 1999-06-28 JP JP2000557229A patent/JP2002519340A/ja not_active Withdrawn
- 1999-06-28 DK DK99932002T patent/DK1089968T3/da active
- 1999-06-28 PT PT99932002T patent/PT1089968E/pt unknown
- 1999-06-28 AU AU48401/99A patent/AU4840199A/en not_active Abandoned
- 1999-06-28 WO PCT/US1999/014627 patent/WO2000000468A1/fr active IP Right Grant
- 1999-06-28 KR KR1020007014984A patent/KR20010053277A/ko not_active Application Discontinuation
- 1999-06-28 DE DE69924846T patent/DE69924846T2/de not_active Expired - Lifetime
- 1999-06-28 IL IL14014099A patent/IL140140A0/xx unknown
- 1999-06-30 US US09/345,673 patent/US6107517A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1598334A1 (fr) | 2005-11-23 |
| ES2241294T3 (es) | 2005-10-16 |
| CA2335551A1 (fr) | 2000-01-06 |
| EP1089968B1 (fr) | 2005-04-20 |
| DE69924846D1 (de) | 2005-05-25 |
| IL140140A0 (en) | 2002-02-10 |
| US6107517A (en) | 2000-08-22 |
| ATE293595T1 (de) | 2005-05-15 |
| PT1089968E (pt) | 2005-08-31 |
| WO2000000468A1 (fr) | 2000-01-06 |
| EP1089968A1 (fr) | 2001-04-11 |
| CA2335551C (fr) | 2009-03-03 |
| JP2002519340A (ja) | 2002-07-02 |
| EP1089968A4 (fr) | 2002-08-21 |
| DE69924846T2 (de) | 2006-04-27 |
| AU4840199A (en) | 2000-01-17 |
| KR20010053277A (ko) | 2001-06-25 |
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