DK1054874T3 - Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler - Google Patents
Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midlerInfo
- Publication number
- DK1054874T3 DK1054874T3 DK99904393T DK99904393T DK1054874T3 DK 1054874 T3 DK1054874 T3 DK 1054874T3 DK 99904393 T DK99904393 T DK 99904393T DK 99904393 T DK99904393 T DK 99904393T DK 1054874 T3 DK1054874 T3 DK 1054874T3
- Authority
- DK
- Denmark
- Prior art keywords
- antimicrobial agents
- substituted
- aminophenylisoxazoline
- derivatives useful
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7512698P | 1998-02-13 | 1998-02-13 | |
| PCT/US1999/001854 WO1999041244A1 (fr) | 1998-02-13 | 1999-02-03 | Derives d'isoxazoline aminophenyle substitues utilises comme agents antimicrobiens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1054874T3 true DK1054874T3 (da) | 2002-12-30 |
Family
ID=22123719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99904393T DK1054874T3 (da) | 1998-02-13 | 1999-02-03 | Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6069141A (fr) |
| EP (1) | EP1054874B1 (fr) |
| JP (1) | JP2002503655A (fr) |
| AT (1) | ATE222894T1 (fr) |
| AU (1) | AU757197B2 (fr) |
| CA (1) | CA2315735A1 (fr) |
| DE (1) | DE69902634T2 (fr) |
| DK (1) | DK1054874T3 (fr) |
| ES (1) | ES2182485T3 (fr) |
| NZ (1) | NZ506292A (fr) |
| PT (1) | PT1054874E (fr) |
| WO (1) | WO1999041244A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311787A (zh) | 1998-06-05 | 2001-09-05 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物 |
| WO2000008001A1 (fr) * | 1998-08-07 | 2000-02-17 | Chiron Corporation | Isoxazoles substitues comme modulateurs de recepteur d'oestrogenes |
| US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| GB9928568D0 (en) * | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| ES2256331T3 (es) | 2000-12-21 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas. |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| EP1443930A1 (fr) * | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Derives d'isoxazoline utilises en tant qu'agents antimicrobiens |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| US7105547B2 (en) | 2002-10-10 | 2006-09-12 | Pharmacia And Upjohn Company | Antimicrobial 1-aryl dihydropyridone compounds |
| PL1656372T3 (pl) * | 2003-07-30 | 2013-08-30 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym |
| GB0403629D0 (en) * | 2004-02-19 | 2004-03-24 | Imp College Innovations Ltd | Methods |
| CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| TW200626155A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| BRPI0515478A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase |
| CN101083982A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物 |
| WO2006034279A1 (fr) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation comme agents therapeutiques |
| AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| TW200626154A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| US20060258691A1 (en) * | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Methods and compositions for improving cognition |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| EP1919482A1 (fr) * | 2005-08-24 | 2008-05-14 | Lexicon Pharmaceuticals, Inc. | Dérivés de pyrrolopyridine, pyrrolopyrimidine et pyrazolopyridine, préparations les incluant et méthodes d'application |
| CN101070308B (zh) * | 2007-06-19 | 2011-05-04 | 天津药物研究院 | 异噁唑啉衍生物及其用途 |
| CN101220000B (zh) * | 2007-12-28 | 2010-12-22 | 天津药物研究院 | 酰氯和磺酰氯类衍生物及其用途 |
| WO2009102761A1 (fr) * | 2008-02-12 | 2009-08-20 | Bristol-Myers Squibb Company | 1,2,3-triazoles en tant qu'inhibiteurs de 11-bêta-hydroxysteroïde déshydrogénase type i |
| CN101675931B (zh) * | 2008-09-19 | 2011-09-07 | 天津药物研究院 | 酰氯和磺酰氯类衍生物在制备抗肿瘤药物的用途 |
| CN101781294B (zh) * | 2010-03-10 | 2012-02-01 | 天津药物研究院 | 一类咪唑的衍生物、其制备方法和用途 |
| EP2602248A1 (fr) | 2011-12-05 | 2013-06-12 | University Of Leicester | Nouveaux composés pyrroliques |
| CA2985542C (fr) | 2015-05-20 | 2023-10-10 | Amgen Inc. | Triazoles agonistes du recepteur apj |
| EP3452466B1 (fr) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018093579A1 (fr) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Composés phényle triazole en tant qu'agonistes du récepteur apj |
| MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| US10689367B2 (en) | 2016-11-16 | 2020-06-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the APJ receptor |
| WO2018097944A1 (fr) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj |
| CN110831599B (zh) * | 2017-02-03 | 2023-03-28 | 布罗德研究所股份有限公司 | 用于癌症治疗的化合物、组合物和方法 |
| US11149040B2 (en) | 2017-11-03 | 2021-10-19 | Amgen Inc. | Fused triazole agonists of the APJ receptor |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| WO2021000297A1 (fr) * | 2019-07-03 | 2021-01-07 | Merck Sharp & Dohme Corp. | Composés et leurs procédés d'utilisation en tant qu'agents antibactériens |
| CN113372276B (zh) * | 2021-05-25 | 2022-04-22 | 三峡大学 | 吲唑类衍生物及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137326C (fr) * | 1967-08-26 | |||
| IE44819B1 (en) * | 1976-06-14 | 1982-04-07 | Lilly Co Eli | Isoxazoline derivatives and their use as fungicides |
| US4283403A (en) * | 1976-06-14 | 1981-08-11 | Eli Lilly And Company | Substituted isoxazolines for control of plant phytopathogens |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| WO1995014684A1 (fr) * | 1993-11-22 | 1995-06-01 | The Upjohn Company | Esters d'hydroxyacetyl-piperazine-phenyl-oxazolidinones substituees |
| ES2139754T3 (es) * | 1993-11-26 | 2000-02-16 | Pfizer | 3-fenil-2-isoxazolinas como agentes antiinflamatorios. |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| ATE204277T1 (de) * | 1994-10-26 | 2001-09-15 | Upjohn Co | Phenyloxazolidinone mit antimikrobieller wirkung |
| ATE205205T1 (de) * | 1995-02-03 | 2001-09-15 | Upjohn Co | Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel |
| ZA969622B (en) * | 1995-12-13 | 1998-05-15 | Upjohn Co | Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring. |
| ES2186916T3 (es) * | 1996-08-21 | 2003-05-16 | Upjohn Co | Derivados de isoxazolina como agentes antimicrobianos. |
| JP2002501530A (ja) * | 1997-05-30 | 2002-01-15 | ファルマシア・アンド・アップジョン・カンパニー | チオカルボニル官能基を有するオキサゾリジノン抗菌剤 |
-
1999
- 1999-02-03 CA CA002315735A patent/CA2315735A1/fr not_active Abandoned
- 1999-02-03 AT AT99904393T patent/ATE222894T1/de not_active IP Right Cessation
- 1999-02-03 NZ NZ506292A patent/NZ506292A/en unknown
- 1999-02-03 DK DK99904393T patent/DK1054874T3/da active
- 1999-02-03 WO PCT/US1999/001854 patent/WO1999041244A1/fr active IP Right Grant
- 1999-02-03 EP EP99904393A patent/EP1054874B1/fr not_active Expired - Lifetime
- 1999-02-03 PT PT99904393T patent/PT1054874E/pt unknown
- 1999-02-03 DE DE69902634T patent/DE69902634T2/de not_active Expired - Fee Related
- 1999-02-03 US US09/243,871 patent/US6069141A/en not_active Expired - Fee Related
- 1999-02-03 JP JP2000531439A patent/JP2002503655A/ja active Pending
- 1999-02-03 AU AU24797/99A patent/AU757197B2/en not_active Ceased
- 1999-02-03 ES ES99904393T patent/ES2182485T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE222894T1 (de) | 2002-09-15 |
| EP1054874B1 (fr) | 2002-08-28 |
| DE69902634D1 (de) | 2002-10-02 |
| DE69902634T2 (de) | 2003-04-24 |
| CA2315735A1 (fr) | 1999-08-19 |
| ES2182485T3 (es) | 2003-03-01 |
| NZ506292A (en) | 2003-05-30 |
| EP1054874A1 (fr) | 2000-11-29 |
| US6069141A (en) | 2000-05-30 |
| AU2479799A (en) | 1999-08-30 |
| PT1054874E (pt) | 2003-01-31 |
| AU757197B2 (en) | 2003-02-06 |
| JP2002503655A (ja) | 2002-02-05 |
| WO1999041244A1 (fr) | 1999-08-19 |
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