DK10488A - Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf - Google Patents

Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf

Info

Publication number
DK10488A
DK10488A DK010488A DK10488A DK10488A DK 10488 A DK10488 A DK 10488A DK 010488 A DK010488 A DK 010488A DK 10488 A DK10488 A DK 10488A DK 10488 A DK10488 A DK 10488A
Authority
DK
Denmark
Prior art keywords
preparing
procedure
derivatives
inflammatory effect
benzen
Prior art date
Application number
DK010488A
Other languages
Danish (da)
English (en)
Other versions
DK10488D0 (da
Inventor
Nancy Grace Bollinger
Jr Theodore Goodson
David Kent Herron
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK10488D0 publication Critical patent/DK10488D0/da
Publication of DK10488A publication Critical patent/DK10488A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK010488A 1987-01-12 1988-01-11 Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf DK10488A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US254287A 1987-01-12 1987-01-12

Publications (2)

Publication Number Publication Date
DK10488D0 DK10488D0 (da) 1988-01-11
DK10488A true DK10488A (da) 1988-09-19

Family

ID=21701261

Family Applications (1)

Application Number Title Priority Date Filing Date
DK010488A DK10488A (da) 1987-01-12 1988-01-11 Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf

Country Status (18)

Country Link
EP (1) EP0276065B1 (pt)
JP (1) JP2710619B2 (pt)
KR (1) KR880008969A (pt)
CN (1) CN88100650A (pt)
AT (1) ATE53376T1 (pt)
CA (1) CA1315279C (pt)
DE (1) DE3860201D1 (pt)
DK (1) DK10488A (pt)
ES (1) ES2036259T3 (pt)
GR (1) GR3000750T3 (pt)
HU (1) HU200313B (pt)
IE (1) IE61256B1 (pt)
MX (1) MX10059A (pt)
NZ (1) NZ223151A (pt)
PH (1) PH25130A (pt)
PT (1) PT86520B (pt)
RU (1) RU1833372C (pt)
ZA (1) ZA88154B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
US4820723A (en) * 1987-08-14 1989-04-11 Eli Lilly And Company Disubstituted tetrazole leukotriene antagonists and methods for their use thereas
US5527945A (en) * 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
DE3903989A1 (de) * 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US5256686A (en) * 1989-06-27 1993-10-26 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
US6001877A (en) * 1989-06-27 1999-12-14 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
JP2638653B2 (ja) * 1990-01-19 1997-08-06 富士写真フイルム株式会社 写真プリント作成方法
JPH04297466A (ja) * 1990-06-22 1992-10-21 Nippon Shinyaku Co Ltd テトラゾール誘導体及び医薬
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP2613311B2 (ja) * 1990-09-03 1997-05-28 富士写真フイルム株式会社 写真プリント方法
EP0548250B1 (en) * 1990-09-10 1996-03-27 Rhone-Poulenc Rorer International (Holdings) Inc. Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
DE4201942A1 (de) * 1991-02-26 1992-09-24 Plantamed Arzneimittel Gmbh Phenonverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
EP0516069B1 (en) * 1991-05-31 1996-04-24 Sumitomo Pharmaceuticals Company, Limited Leukotriene B4 antagonist
WO2003045306A2 (en) 2001-11-13 2003-06-05 Emisphere Technologies, Inc. Phenoxy amine compounds and compositions for delivering active agents
EP1881950A1 (en) * 2005-05-09 2008-01-30 AstraZeneca AB New compounds i
SI3083564T1 (sl) 2013-12-20 2018-10-30 Novartis Ag Derivati heteroarilbutanojske kisline kot inhibitorji LTA4H

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1111337A (en) * 1964-07-24 1968-04-24 Fisons Pharmaceuticals Ltd Substituted aralkyl alcohols
JPS5233108B2 (pt) * 1971-09-13 1977-08-26
JPS5233107B2 (pt) * 1971-09-13 1977-08-26
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
JPS5233623B2 (pt) * 1972-01-11 1977-08-30
JPS5233109B2 (pt) * 1971-12-29 1977-08-26
US3830764A (en) * 1972-07-06 1974-08-20 Princeton Polymer Lab Degradable hydrocarbon polymers
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
US4301267A (en) * 1980-08-26 1981-11-17 Gaf Corporation Ultraviolet light stable copolymer compositions comprising monomers which are α,62 -unsaturated dicarboxylic acid half-esters of 2-hydroxy, alkoxy, methylolbenzophenones and styrene-butadiene comonomers
CA1206964A (en) * 1980-11-12 1986-07-02 Nobuo Shinma Tetra-substituted benzene derivatives
US4507498A (en) * 1982-04-09 1985-03-26 Hoffmann-La Roche Inc. Phenoxycarboxylic acids
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
DD235450B1 (de) * 1983-12-29 1988-02-03 Humboldt Uni Z Berlin Verfahren zur herstellung neuer 1-(2-hydroxyaryl)-alkan-1-on-oxime

Also Published As

Publication number Publication date
AU1016488A (en) 1988-07-14
JP2710619B2 (ja) 1998-02-10
IE61256B1 (en) 1994-10-19
CN88100650A (zh) 1988-10-19
IE880061L (en) 1988-07-12
EP0276065A1 (en) 1988-07-27
DK10488D0 (da) 1988-01-11
PT86520B (pt) 1991-12-31
GR3000750T3 (en) 1991-10-10
DE3860201D1 (de) 1990-07-12
EP0276065B1 (en) 1990-06-06
HU200313B (en) 1990-05-28
NZ223151A (en) 1989-10-27
JPS63188644A (ja) 1988-08-04
AU601011B2 (en) 1990-08-30
KR880008969A (ko) 1988-09-13
PH25130A (en) 1991-02-19
PT86520A (en) 1988-02-01
ATE53376T1 (de) 1990-06-15
HUT45960A (en) 1988-09-28
CA1315279C (en) 1993-03-30
RU1833372C (ru) 1993-08-07
MX10059A (es) 1993-12-01
ES2036259T3 (es) 1993-05-16
ZA88154B (en) 1989-09-27

Similar Documents

Publication Publication Date Title
DK10488D0 (da) Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf
IS1564B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
DK502888A (da) Anvendelse af azithromycin og derivater deraf til fremstilling af antiprotozoale laegemidler
NO884467D0 (no) Analogifremgangsmaate for fremstilling av aminomethyloxooxazolidinyl-ycloalkylbenzenderivater.
NO890259D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive etylfenoksyacetamider.
DK249389D0 (da) 2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer
DK84088D0 (da) Naphthalenderivater med anvendelse som antiallergiske og antiinflammatoriske midler
DK561089A (da) Anvendelse af lactamimider til fremstilling af laegemidler
FI891986A (fi) Farmaceutiska sammansaettningar foer behandling av psoriasis.
IT8721691A0 (it) Derivati dell'ossima della 1,2,5,6-tetraidropirdin-3-carbossaldeide, loro procedimento di preparazione e loro impiegocome sostanze medicinali.
IT8721687A0 (it) Derivati dell'ossima della 1,2,5,6-tetraidropiridin-3-carbossa ldeide, loro procedimento di preparazione e loro impiego come sostanze medicinali.
IT1233446B (it) Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
EP0618812A4 (en) USE OF PROTEASE NEXIN-I AS ANTI-INFLAMMATORY.
NO922635L (no) Ny anvendelse av benzimidazolin-2-okso-1-karboksylsyrederivater
ITMI911758A1 (it) Derivati della fisovenina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT8520877A0 (it) Procedimento di preparazione di derivati del 9h-xanthen-9-one, derivati cosi' ottenuti e loro impiego terapeutico.
IT7926323A0 (it) Farmaco per la cura delle leucosi e di sindroni nevrotiche.
IT8867820A0 (it) Procedimento di preparazione di derivati dell'1,4-benzodiazepina-4-one
ITMI911841A1 (it) Derivati dell'eseridina utili per il trattamento delle malattie associaate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ITMI912027A1 (it) Derivati dell'eserolina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ITMI911842A1 (it) Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ITMI911713A1 (it) Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.

Legal Events

Date Code Title Description
ATS Application withdrawn