DK0979410T3 - Fremgangsmåde til bestemmelse af cytokinreceptoraktivering ved anvendelse af et antistof - Google Patents

Fremgangsmåde til bestemmelse af cytokinreceptoraktivering ved anvendelse af et antistof

Info

Publication number
DK0979410T3
DK0979410T3 DK98911331T DK98911331T DK0979410T3 DK 0979410 T3 DK0979410 T3 DK 0979410T3 DK 98911331 T DK98911331 T DK 98911331T DK 98911331 T DK98911331 T DK 98911331T DK 0979410 T3 DK0979410 T3 DK 0979410T3
Authority
DK
Denmark
Prior art keywords
antibody
cytokine receptor
receptor
conformation
inactive
Prior art date
Application number
DK98911331T
Other languages
English (en)
Inventor
Alonso Carlos Martinez
Garcia Jose Mario Mellado
Baron Leonor Kremer
Frade Jose Miguel Rodriguez
Original Assignee
Pharmacia Spain S A
Consejo Superior Investigacion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spain S A, Consejo Superior Investigacion filed Critical Pharmacia Spain S A
Priority claimed from PCT/SE1998/000796 external-priority patent/WO1998049817A1/en
Application granted granted Critical
Publication of DK0979410T3 publication Critical patent/DK0979410T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/61—Growth hormones [GH] (Somatotropin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK98911331T 1997-03-19 1998-03-19 Fremgangsmåde til bestemmelse af cytokinreceptoraktivering ved anvendelse af et antistof DK0979410T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9701010A SE9701010D0 (sv) 1997-03-19 1997-03-19 Antibody
EP98911331A EP0979410B1 (en) 1997-03-19 1998-03-19 Method for determining cytokine receptor activation by the use of an antibody
PCT/SE1998/000796 WO1998049817A1 (en) 1997-04-30 1998-04-29 Automatic service registration

Publications (1)

Publication Number Publication Date
DK0979410T3 true DK0979410T3 (da) 2004-11-22

Family

ID=20406234

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98911331T DK0979410T3 (da) 1997-03-19 1998-03-19 Fremgangsmåde til bestemmelse af cytokinreceptoraktivering ved anvendelse af et antistof

Country Status (13)

Country Link
US (1) US6645723B2 (da)
EP (1) EP0979410B1 (da)
JP (1) JP2001524816A (da)
AT (1) ATE273514T1 (da)
AU (1) AU739758B2 (da)
CA (1) CA2285036A1 (da)
DE (1) DE69825583T2 (da)
DK (1) DK0979410T3 (da)
ES (1) ES2224367T3 (da)
NZ (1) NZ337636A (da)
PT (1) PT979410E (da)
SE (1) SE9701010D0 (da)
WO (1) WO1998041872A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
DE10306992A1 (de) * 2003-02-19 2005-08-11 Klinikum der Universität München Großhadern-Innenstadt Verfahren zur quantitativen Messung von Liganden in der Probe gelöster Bindungsproteine
SE0301917D0 (sv) 2003-06-30 2003-06-30 Biovitrum Ab Methods for identifying active compounds
JP2005325055A (ja) * 2004-05-14 2005-11-24 Peptide Door Co Ltd リガンド結合タンパク質含有複合体及びリガンド結合タンパク質に結合する物質のスクリーニング方法
EP3256465B1 (en) * 2015-02-12 2021-04-07 University of Southern California Blockers of the growth hormone receptor in disease prevention and treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593844A (en) * 1990-11-19 1997-01-14 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
WO1992021029A1 (en) * 1991-05-10 1992-11-26 Genentech, Inc. Selecting ligand agonists and antagonists
CA2117913C (en) * 1992-04-10 2006-05-09 Richard J. Epstein Activation-state-specific phosphoprotein immunodetection
US5470952A (en) * 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists

Also Published As

Publication number Publication date
AU6530498A (en) 1998-10-12
US20030077663A1 (en) 2003-04-24
NZ337636A (en) 2001-06-29
EP0979410B1 (en) 2004-08-11
SE9701010D0 (sv) 1997-03-19
WO1998041872A1 (en) 1998-09-24
JP2001524816A (ja) 2001-12-04
DE69825583D1 (de) 2004-09-16
DE69825583T2 (de) 2005-08-11
AU739758B2 (en) 2001-10-18
ES2224367T3 (es) 2005-03-01
PT979410E (pt) 2004-11-30
ATE273514T1 (de) 2004-08-15
US6645723B2 (en) 2003-11-11
EP0979410A1 (en) 2000-02-16
CA2285036A1 (en) 1998-09-24

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