DK0973550T3 - Antagonistiske anti-AVB3-integrin-antistoffer - Google Patents
Antagonistiske anti-AVB3-integrin-antistofferInfo
- Publication number
- DK0973550T3 DK0973550T3 DK98915334T DK98915334T DK0973550T3 DK 0973550 T3 DK0973550 T3 DK 0973550T3 DK 98915334 T DK98915334 T DK 98915334T DK 98915334 T DK98915334 T DK 98915334T DK 0973550 T3 DK0973550 T3 DK 0973550T3
- Authority
- DK
- Denmark
- Prior art keywords
- integrin antibodies
- antagonistic anti
- avb3 integrin
- avb3
- integrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4385397P | 1997-04-11 | 1997-04-11 | |
PCT/US1998/006867 WO1998046264A1 (en) | 1997-04-11 | 1998-04-09 | Antagonistic anti-avb3 integrin antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0973550T3 true DK0973550T3 (da) | 2003-02-10 |
Family
ID=21929212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98915334T DK0973550T3 (da) | 1997-04-11 | 1998-04-09 | Antagonistiske anti-AVB3-integrin-antistoffer |
Country Status (11)
Country | Link |
---|---|
US (1) | US6171588B1 (de) |
EP (1) | EP0973550B1 (de) |
JP (1) | JP2001521520A (de) |
AT (1) | ATE225670T1 (de) |
AU (1) | AU6954398A (de) |
CA (1) | CA2284726A1 (de) |
DE (1) | DE69808609T2 (de) |
DK (1) | DK0973550T3 (de) |
ES (1) | ES2187954T3 (de) |
PT (1) | PT973550E (de) |
WO (1) | WO1998046264A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69824039T2 (de) | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
CN1318092C (zh) * | 1998-04-15 | 2007-05-30 | 利思进药品公司 | 含有抗体-细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物 |
US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
DK1200479T3 (da) | 1999-08-09 | 2006-05-15 | Emd Lexigen Res Ct Corp | Multiple cytokin-antistof-komplekser |
JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
CN1406249B (zh) | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
ATE368475T1 (de) * | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
US7288390B2 (en) * | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
US20030129223A1 (en) * | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
US20030082103A1 (en) * | 2000-10-11 | 2003-05-01 | Targesome, Inc. | Targeted therapeutic lipid constructs having cell surface targets |
US20030133972A1 (en) * | 2000-10-11 | 2003-07-17 | Targesome, Inc. | Targeted multivalent macromolecules |
EP1372720A4 (de) * | 2001-03-02 | 2006-07-26 | Medimmune Inc | Verfahren zur prävention oder behandlung von entzündlichen erkrankungen oder autoimmunkrankheiten durch verabreichung von integrin-alphav-beta3-antagonisten |
PL206701B1 (pl) * | 2001-03-07 | 2010-09-30 | Merck Patent Gmbh | Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego |
US20020197210A1 (en) * | 2001-03-08 | 2002-12-26 | Bednarski Mark David | Stabilized therapeutic and imaging agents |
WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
PL363311A1 (en) * | 2001-04-24 | 2004-11-15 | Merck Patent Gmbh | Combination therapy using anti-angiogenic agents and tnfalpha |
PL205352B1 (pl) | 2001-05-03 | 2010-04-30 | Merck Patent Gmbh | Rekombinowane przeciwciało specyficzne dla nowotworu |
WO2003034995A2 (en) * | 2001-10-22 | 2003-05-01 | The Scripps Research Institute | Integrin targeting compounds |
JP4795640B2 (ja) * | 2001-12-04 | 2011-10-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 調節された選択性を有する免疫サイトカイン |
KR100978126B1 (ko) | 2002-01-24 | 2010-08-26 | 반즈 쥬이쉬 하스피털 | 인테그린 표적화 조영제 |
CA2478317A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
EP1487492A4 (de) * | 2002-03-04 | 2008-10-01 | Medimmune Inc | Prävention oder behandlung von krebs mit integrin alphavbeta3 antagonisten in kombination mit anderen mitteln |
CA2481747A1 (en) * | 2002-04-12 | 2003-10-23 | Medimmune, Inc. | Recombinant anti-interleukin-9 antibodies |
US20040081653A1 (en) * | 2002-08-16 | 2004-04-29 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer |
AU2003298187B2 (en) * | 2002-12-17 | 2010-09-16 | Merck Patent Gmbh | Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2 |
SG172479A1 (en) * | 2003-01-22 | 2011-07-28 | Univ Singapore | Molecules, compositions, methods and kits for applications associated with flaviviruses |
US20040176272A1 (en) * | 2003-01-30 | 2004-09-09 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
EP1613273B1 (de) * | 2003-04-11 | 2012-06-13 | MedImmune, LLC | Rekombinante il-9-antikörper und ihre verwendung |
US7271245B2 (en) * | 2004-02-13 | 2007-09-18 | The Scripps Research Institute | Methods and compositions for inhibition of metastasis |
US7351739B2 (en) | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
EP1809326A4 (de) | 2004-10-27 | 2009-11-04 | Medimmune Inc | Modulation von antikörperspezifität mittels anpassung der affinität zu verwandten antigenen |
WO2008008373A2 (en) | 2006-07-11 | 2008-01-17 | Arubor Corp | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
CA3177366A1 (en) | 2006-08-10 | 2008-02-21 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
KR101405440B1 (ko) | 2012-07-31 | 2014-06-20 | 연세대학교 산학협력단 | 인테그린αvβ3에 특이적 압타머 및 이의 용도 |
AU2017204125B1 (en) | 2016-06-17 | 2017-10-26 | Crispr Therapeutics Ag | Compositions and methods for the depletion of cd117+ cells |
US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
KR102101561B1 (ko) * | 2018-07-25 | 2020-04-20 | 가톨릭대학교 산학협력단 | 신생혈관 표적용 조영제 조성물 및 이의 제조방법 |
US20220133913A1 (en) * | 2019-07-24 | 2022-05-05 | Korea Basic Science Institute | SINGLE DOMAIN ANTIBODY TARGETING aVB3 INTEGRIN |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4897255A (en) | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US4965392A (en) | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
US5591829A (en) | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
US5306620A (en) | 1987-07-08 | 1994-04-26 | The Scripps Research Institute | Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation |
US5130118A (en) | 1987-11-06 | 1992-07-14 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
WO1989005155A1 (en) * | 1987-11-19 | 1989-06-15 | Scripps Clinic And Research Foundation | Monoclonal antibody against the rgd-directed adhesion receptor of endothelial cells |
US5057604A (en) | 1988-08-03 | 1991-10-15 | Washington University | Novel monoclonal antibodies |
US5149780A (en) | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
JP3093383B2 (ja) | 1990-11-30 | 2000-10-03 | 塩野義製薬株式会社 | 抗体標識のための放射性ヨウ素化合物 |
ATE175241T1 (de) * | 1992-04-03 | 1999-01-15 | Genentech Inc | Antikörper gegen alpha v beta 3 integrin |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
DE4338704A1 (de) | 1993-11-12 | 1995-05-18 | Hoechst Ag | Stabilisierte Oligonucleotide und deren Verwendung |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
-
1998
- 1998-04-09 CA CA002284726A patent/CA2284726A1/en not_active Abandoned
- 1998-04-09 AT AT98915334T patent/ATE225670T1/de not_active IP Right Cessation
- 1998-04-09 AU AU69543/98A patent/AU6954398A/en not_active Abandoned
- 1998-04-09 JP JP54398898A patent/JP2001521520A/ja not_active Abandoned
- 1998-04-09 PT PT98915334T patent/PT973550E/pt unknown
- 1998-04-09 DE DE69808609T patent/DE69808609T2/de not_active Expired - Fee Related
- 1998-04-09 DK DK98915334T patent/DK0973550T3/da active
- 1998-04-09 US US09/057,486 patent/US6171588B1/en not_active Expired - Fee Related
- 1998-04-09 ES ES98915334T patent/ES2187954T3/es not_active Expired - Lifetime
- 1998-04-09 WO PCT/US1998/006867 patent/WO1998046264A1/en active IP Right Grant
- 1998-04-09 EP EP98915334A patent/EP0973550B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2284726A1 (en) | 1998-10-22 |
JP2001521520A (ja) | 2001-11-06 |
AU6954398A (en) | 1998-11-11 |
DE69808609T2 (de) | 2003-06-12 |
ES2187954T3 (es) | 2003-06-16 |
ATE225670T1 (de) | 2002-10-15 |
WO1998046264A1 (en) | 1998-10-22 |
EP0973550B1 (de) | 2002-10-09 |
EP0973550A1 (de) | 2000-01-26 |
US6171588B1 (en) | 2001-01-09 |
DE69808609D1 (de) | 2002-11-14 |
PT973550E (pt) | 2003-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE225670T1 (de) | Antagonistische anti-avb3 integrin antikörper | |
TR199501614A2 (tr) | Anti-alfa integrin monoklonal antikor. | |
RS53984B1 (en) | IP-10 ANTIBODIES AND THEIR USES | |
DE69920897D1 (de) | Monoklonale antikörper mit verringerter immunisierungsfähigkeit | |
AU8316701A (en) | Anti-dual integrin antibodies, compositions, methods and uses | |
EE200100336A (et) | CTLA-4 vastased inimese monoklonaalsed antikehad | |
EE201200006A (et) | CTLA-4 vastased inimese monoklonaalsed antikehad | |
NO924279D0 (no) | Lyofilisert, monoklonalt antistoffpreparat | |
DE69829891D1 (de) | Anti-VEGF Antikörper | |
IL147517A0 (en) | Monoclonal antibodies and immunoassay utilizing the same | |
PL330842A1 (en) | Purified superficial sperm antigen, monoclonal antibody therefor and applications associated therewith | |
ATE476989T1 (de) | Humanisierter monoklonaler antikörper gegen von- willebrand faktor | |
DE69828154D1 (de) | Anti-alphavbeta3 humanizierte monoklonale antikörper | |
DE69738312D1 (de) | Hepatitis b monoklonale antikörper | |
HUP0103152A3 (en) | Monoclonal antibodies directed against the g3bp protein, and uses | |
TR199800517A3 (tr) | Hümanize anti-hümen fas antikor. | |
BR0015872A (pt) | Agentes antitrombóticos | |
EP0759943A4 (de) | Monoklonale antikörper spezifisch gegen vaskuläres endothelzellartigen endoglyx-1, das antigen selbst und seine verwendungen | |
NO20004251D0 (no) | Humaniserte anti-CEA monoklonale antistoffer med høy affinitet | |
ATE293685T1 (de) | Monoklonaler antikörper gegen ratte beta-2- integrin alpha d untereinheit und entsprechendes hybridoma | |
DE69023717D1 (de) | Monoklonaler Antikörper. | |
BR1100555B1 (pt) | anticorpos monoclonais humanizados. | |
TW288020B (en) | Monoclonal antibodies specific to methamphetamine, hybridoma producing the antibodies, kits containing the antibodies and uses thereof | |
ZA986064B (en) | Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and their use. | |
NO985281D0 (no) | Monoklonalt antihumant MP52-antistoff |