DK0968295T3 - Vektorer med foröget ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf - Google Patents

Vektorer med foröget ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf

Info

Publication number
DK0968295T3
DK0968295T3 DK98908723T DK98908723T DK0968295T3 DK 0968295 T3 DK0968295 T3 DK 0968295T3 DK 98908723 T DK98908723 T DK 98908723T DK 98908723 T DK98908723 T DK 98908723T DK 0968295 T3 DK0968295 T3 DK 0968295T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
acid molecule
reading frame
open reading
expression
Prior art date
Application number
DK98908723T
Other languages
English (en)
Inventor
Bertram L Jacobs
James Tartaglia
William I Cox
Russell Robert Gettig
Steven E Pincus
Enzo Paoletti
Scott J Goebel
Original Assignee
Connaught Technology Corp
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Technology Corp, Univ Arizona filed Critical Connaught Technology Corp
Application granted granted Critical
Publication of DK0968295T3 publication Critical patent/DK0968295T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Image Generation (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DK98908723T 1997-03-12 1998-02-25 Vektorer med foröget ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf DK0968295T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/815,809 US6004777A (en) 1997-03-12 1997-03-12 Vectors having enhanced expression, and methods of making and uses thereof
PCT/US1998/003710 WO1998040500A1 (en) 1997-03-12 1998-02-25 Vectors having enhanced expression and methods of making and uses thereof

Publications (1)

Publication Number Publication Date
DK0968295T3 true DK0968295T3 (da) 2008-09-29

Family

ID=25218894

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98908723T DK0968295T3 (da) 1997-03-12 1998-02-25 Vektorer med foröget ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf

Country Status (10)

Country Link
US (1) US6004777A (da)
EP (1) EP0968295B1 (da)
JP (1) JP2001514519A (da)
AT (1) ATE397078T1 (da)
AU (1) AU745836B2 (da)
CA (1) CA2283462C (da)
DE (1) DE69839554D1 (da)
DK (1) DK0968295T3 (da)
ES (1) ES2307315T3 (da)
WO (1) WO1998040500A1 (da)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767449B1 (en) 1981-12-24 2010-08-03 Health Research Incorporated Methods using modified vaccinia virus
ZA973642B (en) * 1996-04-26 1997-11-25 Merck & Co Inc DNA vaccine formulations.
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
US6762038B1 (en) * 1998-09-09 2004-07-13 The Cleveland Clinic Foundation Mutant cell lines and methods for producing enhanced levels of recombinant proteins
WO2000073487A1 (en) * 1999-05-27 2000-12-07 Arizona Board Of Regents Novel viral vectors having enhanced effectiveness with dramatically reduced virulence
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
WO2002009650A2 (en) 2000-07-31 2002-02-07 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
US7547674B2 (en) * 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
EP1350100A2 (en) 2000-09-26 2003-10-08 Health Research, Incorporated Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients
AU2002250064B2 (en) * 2001-02-13 2008-01-17 University Of Florida Research Foundation, Inc. A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes
US6372455B1 (en) 2001-04-19 2002-04-16 Arizona Board Of Regents Recombinant vaccinia viral vectors
US7013940B2 (en) * 2001-04-19 2006-03-21 Michelin Recherche Et Technique S.A. Device for attenuating cavity noise in a tire and wheel
US6750043B2 (en) 2001-04-19 2004-06-15 Arizona Board Of Regents Viral vectors having reduced virulence
DE10144664B4 (de) 2001-09-11 2005-06-09 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon
DE60238864D1 (de) * 2001-11-07 2011-02-17 Mankind Corp Für epitope von antigenen kodierende expressionsvektoren und verfahren zu deren konzeption
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
EP1523333A4 (en) * 2002-07-24 2007-01-24 Univ Arizona USE OF VACCINIA VIRUS WITH DELETION OF E3L GENE AS VACCINE VECTOR
CA2489301A1 (en) * 2002-08-07 2004-02-19 Bavarian Nordic A/S Vaccinia virus host range genes to increase the titer of avipoxviruses
CA2510229A1 (en) * 2002-12-13 2004-07-08 Aventis Pasteur, Inc. Production of alvac on avian embryonic stem cells
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
EP1648233A4 (en) * 2003-07-08 2006-08-23 Univ Arizona VACCINE VACCINE MUTANTS INSTEAD OF ONCOLYTIC AGENTS
US20050214316A1 (en) 2003-11-13 2005-09-29 Brown Thomas P Methods of characterizing infectious bursal disease virus
AU2005244673B2 (en) 2004-02-19 2009-12-10 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
ES2343270T3 (es) 2005-04-25 2010-07-27 Merial Ltd. Vacunas contra el virus nipah.
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
CA2629522A1 (en) 2005-11-14 2007-05-18 Merial Limited Gene therapy for renal failure
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
WO2007136763A2 (en) * 2006-05-19 2007-11-29 Sanofi Pasteur, Inc. Immunological composition
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
EP2152890A1 (en) * 2007-05-23 2010-02-17 MannKind Corporation Multicistronic vectors and methods for their design
AU2008323719B2 (en) 2007-11-09 2013-04-04 New York Medical College Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
DK2414386T3 (da) 2009-04-03 2016-02-22 Merial Ltd Fuglevacciner med newcastle-sygdomsvirus-vektorer
CA2760315C (en) 2009-04-30 2019-05-28 Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) Modified immunization vectors
PL2611460T3 (pl) 2010-08-31 2017-02-28 Merial, Inc. Szczepionki przeciw herpeswirusom przenoszone z pomocą wirusa choroby newcastle
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
WO2012129295A1 (en) 2011-03-21 2012-09-27 Vaxin Inc. Rapid and prolonged immunologic-therapeutic
EP2694677A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
WO2012138789A2 (en) 2011-04-04 2012-10-11 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
WO2012145577A1 (en) 2011-04-20 2012-10-26 Merial Limited Adjuvanted rabies vaccine with improved viscosity profile
EP2701736A1 (en) 2011-04-25 2014-03-05 Advanced Bioscience Laboratories, Inc. Truncated hiv envelope proteins (env), methods and compositions related thereto
ES2674439T3 (es) 2011-06-01 2018-06-29 Merial, Inc. Administración sin aguja de vacunas contra el VSRRP
LT2741740T (lt) 2011-08-12 2017-08-10 Merial, Inc. Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013138776A1 (en) 2012-03-16 2013-09-19 Merial Limited Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g
WO2014164697A1 (en) 2013-03-12 2014-10-09 Merial Limited Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof
BR112016006192A2 (pt) 2013-09-25 2017-09-26 Zoetis Services Llc composição de vacina de divergente de pcv2b e métodos de uso
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
AU2015343369B2 (en) 2014-11-03 2018-11-22 Georgia Tech Research Corporation Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
EP3261669B1 (en) 2015-02-25 2022-08-03 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
CN116173193A (zh) 2015-04-17 2023-05-30 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
EP3297660A2 (en) 2015-05-20 2018-03-28 The Broad Institute Inc. Shared neoantigens
TW202241500A (zh) 2015-06-09 2022-11-01 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
EA201890110A1 (ru) 2015-06-23 2018-05-31 Мериал, Инк. Рекомбинантные вирусные векторы, содержащие минорные белки prrsv, и способы их получения и применения
BR112018016948A2 (pt) 2016-02-25 2019-01-08 Memorial Sloan Kettering Cancer Center mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos
CA3015650A1 (en) 2016-02-25 2017-08-31 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
US20190346442A1 (en) 2016-04-18 2019-11-14 The Broad Institute, Inc. Improved hla epitope prediction
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
CN111107872A (zh) 2017-05-12 2020-05-05 纪念斯隆-凯特林癌症中心 有用于癌症免疫疗法的牛痘病毒突变体
WO2019055887A1 (en) * 2017-09-16 2019-03-21 City Of Hope PSEUDO-VIRAL PARTICLES OF MULTIVALENT EPSTEIN-BARR VIRUS AND USES THEREOF
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
US20210116450A1 (en) * 2019-10-21 2021-04-22 Moazur Rahman Recombinant expression of the vp2-beta domain in escherichia coli, purification and its use for detection of anti-infectious bursal disease virus antibodies by dipstick and lateral flow strip
MX2022010588A (es) * 2020-02-26 2023-02-09 Tonix Pharma Ltd Vacuna basada en poxvirus recombinantes contra el virus sars-cov-2.
EP4365298A1 (en) * 2021-06-30 2024-05-08 Repli-Tech Co., Ltd. Method of producing negative-strand rna virus vector and produced negative-strand rna virus vector
WO2024015892A1 (en) 2022-07-13 2024-01-18 The Broad Institute, Inc. Hla-ii immunopeptidome methods and systems for antigen discovery

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672359B2 (en) * 1991-03-07 1996-10-03 Virogenetics Corporation Genetically engineered vaccine strain

Also Published As

Publication number Publication date
WO1998040500A1 (en) 1998-09-17
ES2307315T3 (es) 2008-11-16
EP0968295A1 (en) 2000-01-05
CA2283462A1 (en) 1998-09-17
AU6668198A (en) 1998-09-29
CA2283462C (en) 2010-11-16
ATE397078T1 (de) 2008-06-15
EP0968295A4 (en) 2002-06-05
DE69839554D1 (de) 2008-07-10
US6004777A (en) 1999-12-21
AU745836B2 (en) 2002-04-11
JP2001514519A (ja) 2001-09-11
EP0968295B1 (en) 2008-05-28

Similar Documents

Publication Publication Date Title
DK0968295T3 (da) Vektorer med foröget ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf
DK1475443T3 (da) Vektorer med forhøjet ekspression og fremgangsmåder til at fremstille disse samt anvendelser heraf
Huet et al. Dissociation of two polypeptide chains from yeast RNA polymerase A.
NO20015787L (no) Fremgangsmate for a skaffe in vitro rekombinerte polynukleotidsekvenser, sekvensbanker og resulterende sekvenser
FI965297A (fi) Uusi LERK-5:ksi nimetty sytokiini
ES2109924T3 (es) Metodo rapido, versatil y simple de expresion de genes en celulas eucarioticas.
BG100771A (en) Hematopoeic protein and ways and methods for its preparation
NO179217C (no) Serinproteaser og preparater som omfatter disse, samt DNA-sekvenser, ekspresjonsvektorer og prokaryote eller eukaryote vertsceller for anvendelse ved fremstillingen av dem
ATE271220T1 (de) Borathaltige speicherpuffer und probenverdünner
IL76438A0 (en) Method and kit for silver staining proteins and nucleic acids
DK1082423T3 (da) Cyclin E2-gener og -proteiner
Lotan et al. On the presence of two types of subunit in soybean agglutinin
EA199900261A1 (ru) Генная терапия застойной сердечной недостаточности
Bell et al. A comparison of bovine α-lactalbumin A and B of droughtmaster
NO20000731L (no) Neisseria lactoferinbindingsprotein
Weissenbach et al. Nucleotide sequence of tRNAArgII from brewer's yeast
HUP9801330A2 (hu) Új PKA-kötő fehérjék és alkalmazásuk
MX9606257A (es) Proteinas de sintasa de difosfato de geranilgeranilo, moleculas de acido nucleico, y usos de las mismas.
RU2004139054A (ru) Модифицированные фитазы
ES2111537T3 (es) Inhibidor de la ribonucleasa de placenta humana recombinante y metodo de produccion.
DK0536252T3 (da) Phosphortrilactamer og fremgangsmåde til deres fremstilling
Yaneva et al. Tissue specificity of tightly bound non-histone chromosomal proteins
ATE439368T1 (de) Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung
WO2024059858A3 (en) Approaches to discovering, analyzing, and synthesizing compounds through automated in silico experimentation
KR970006504A (ko) 인체 암억제인자 p53 단백질의 생산 방법