DK0927040T3 - Process for producing estrogens from bouncy urine - Google Patents
Process for producing estrogens from bouncy urineInfo
- Publication number
- DK0927040T3 DK0927040T3 DK96930986T DK96930986T DK0927040T3 DK 0927040 T3 DK0927040 T3 DK 0927040T3 DK 96930986 T DK96930986 T DK 96930986T DK 96930986 T DK96930986 T DK 96930986T DK 0927040 T3 DK0927040 T3 DK 0927040T3
- Authority
- DK
- Denmark
- Prior art keywords
- urine
- gel
- water
- mixture
- oestrogens
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Abstract
Recovery of a phenolics-depleted natural mixture of conjugated oestrogens from the urine of pregnant mares comprises (a) providing a liquid urine (which comprises a urine freed from mucous and solids, a concentrate of the latter or a urine retentate obtained by membrane filtration) and treating it with a water-soluble base to give a pH of at least 12 and subsequently treating with aqueous acid to adjust the pH to 5-8.5; (b) contacting the urine with a hydrophobised silica gel to adsorb the conjugated oestrogens and separating the gel from the mixture; (c) washing the gel with an aqueous buffer adjusted to pH 5-7; and (d) eluting the oestrogens from the gel using a mixture of water and a water-miscible solvent selected from ethers, lower alcohols and lower aliphatic ketones, and optionally concentrating the eluate;
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1996/003819 WO1998008525A1 (en) | 1996-08-30 | 1996-08-30 | Process to obtain oestrogens from mare's urine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0927040T3 true DK0927040T3 (en) | 2004-05-10 |
Family
ID=8166299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96930986T DK0927040T3 (en) | 1996-08-30 | 1996-08-30 | Process for producing estrogens from bouncy urine |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0927040B1 (en) |
| JP (1) | JP4125788B2 (en) |
| AT (1) | ATE264110T1 (en) |
| AU (1) | AU722084B2 (en) |
| CA (1) | CA2263904C (en) |
| CZ (1) | CZ298762B6 (en) |
| DE (3) | DE19681616D2 (en) |
| DK (1) | DK0927040T3 (en) |
| ES (1) | ES2219697T3 (en) |
| HK (1) | HK1023063A1 (en) |
| HU (1) | HU228765B1 (en) |
| IL (1) | IL128671A (en) |
| NO (1) | NO318378B1 (en) |
| PL (1) | PL185920B1 (en) |
| PT (1) | PT927040E (en) |
| SK (1) | SK281367B6 (en) |
| WO (1) | WO1998008525A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10037389A1 (en) | 2000-08-01 | 2002-02-14 | Solvay Pharm Gmbh | Method and device for the enrichment and stabilization of conjugated estrogens from mare's urine |
| DE10159161A1 (en) * | 2001-12-01 | 2003-06-18 | Solvay Pharm Gmbh | Process for obtaining estrogens from mare's urine |
| TWI332400B (en) | 2001-12-14 | 2010-11-01 | Solvay Pharm Gmbh | Preformulation for the tableting of natural mixtures of conjugated estrogens |
| TWI252111B (en) | 2001-12-14 | 2006-04-01 | Solvay Pharm Gmbh | Matrix film tablet with controlled release of a natural mixture of conjugated estrogens |
| AR041121A1 (en) * | 2002-10-11 | 2005-05-04 | Solvay Pharm Gmbh | PROCEDURE FOR OBTAINING A NATURAL MIXTURE OF CONJUGATED STROGENS |
| US20040072814A1 (en) | 2002-10-11 | 2004-04-15 | Solvay Pharmaceuticals Gmbh | Method for obtaining a natural mixture of conjugated equine estrogens depleted in non-conjugated lipophilic compounds |
| CN1332973C (en) * | 2003-03-06 | 2007-08-22 | 深圳市海达克实业有限公司 | Extraction process of conjugated female hormone |
| ES2315691T3 (en) * | 2003-07-17 | 2009-04-01 | Solvay Pharmaceuticals Gmbh | PROCEDURE FOR OBTAINING A NATURAL MIXTURE OF CONJUGATED EQUINE STROGENS. |
-
1996
- 1996-08-30 DE DE19681616D patent/DE19681616D2/en not_active Expired - Lifetime
- 1996-08-30 IL IL12867196A patent/IL128671A/en not_active IP Right Cessation
- 1996-08-30 CZ CZ0059999A patent/CZ298762B6/en not_active IP Right Cessation
- 1996-08-30 JP JP51119498A patent/JP4125788B2/en not_active Expired - Fee Related
- 1996-08-30 HU HU9903670A patent/HU228765B1/en not_active IP Right Cessation
- 1996-08-30 AT AT96930986T patent/ATE264110T1/en active
- 1996-08-30 ES ES96930986T patent/ES2219697T3/en not_active Expired - Lifetime
- 1996-08-30 PT PT96930986T patent/PT927040E/en unknown
- 1996-08-30 PL PL96331885A patent/PL185920B1/en unknown
- 1996-08-30 CA CA002263904A patent/CA2263904C/en not_active Expired - Fee Related
- 1996-08-30 DE DE59610986T patent/DE59610986D1/en not_active Expired - Lifetime
- 1996-08-30 DE DE19681616A patent/DE19681616B4/en not_active Expired - Fee Related
- 1996-08-30 SK SK244-99A patent/SK281367B6/en not_active IP Right Cessation
- 1996-08-30 AU AU69856/96A patent/AU722084B2/en not_active Ceased
- 1996-08-30 EP EP96930986A patent/EP0927040B1/en not_active Expired - Lifetime
- 1996-08-30 WO PCT/EP1996/003819 patent/WO1998008525A1/en active IP Right Grant
- 1996-08-30 DK DK96930986T patent/DK0927040T3/en active
-
1999
- 1999-02-26 NO NO19990953A patent/NO318378B1/en not_active IP Right Cessation
-
2000
- 2000-04-06 HK HK00102091A patent/HK1023063A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ59999A3 (en) | 1999-06-16 |
| HUP9903670A2 (en) | 2000-03-28 |
| DE59610986D1 (en) | 2004-05-19 |
| HU228765B1 (en) | 2013-05-28 |
| PL185920B1 (en) | 2003-08-29 |
| CZ298762B6 (en) | 2008-01-23 |
| IL128671A0 (en) | 2000-01-31 |
| CA2263904A1 (en) | 1998-03-05 |
| JP4125788B2 (en) | 2008-07-30 |
| EP0927040A1 (en) | 1999-07-07 |
| WO1998008525A1 (en) | 1998-03-05 |
| NO990953D0 (en) | 1999-02-26 |
| SK24499A3 (en) | 1999-10-08 |
| SK281367B6 (en) | 2001-02-12 |
| NO318378B1 (en) | 2005-03-14 |
| EP0927040B1 (en) | 2004-04-14 |
| PL331885A1 (en) | 1999-08-16 |
| AU722084B2 (en) | 2000-07-20 |
| ATE264110T1 (en) | 2004-04-15 |
| PT927040E (en) | 2004-08-31 |
| CA2263904C (en) | 2007-08-07 |
| HUP9903670A3 (en) | 2000-05-29 |
| IL128671A (en) | 2001-03-19 |
| ES2219697T3 (en) | 2004-12-01 |
| JP2000517309A (en) | 2000-12-26 |
| NO990953L (en) | 1999-02-26 |
| DE19681616D2 (en) | 1999-09-30 |
| DE19681616B4 (en) | 2006-03-09 |
| HK1023063A1 (en) | 2000-09-01 |
| AU6985696A (en) | 1998-03-19 |
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