DK0858324T3 - Fremgangsmåde til vandig granulering af clarithromycin - Google Patents

Fremgangsmåde til vandig granulering af clarithromycin

Info

Publication number
DK0858324T3
DK0858324T3 DK96937699T DK96937699T DK0858324T3 DK 0858324 T3 DK0858324 T3 DK 0858324T3 DK 96937699 T DK96937699 T DK 96937699T DK 96937699 T DK96937699 T DK 96937699T DK 0858324 T3 DK0858324 T3 DK 0858324T3
Authority
DK
Denmark
Prior art keywords
clarithromycin
aqueous granulation
macrolide antibiotic
carbomer
mixture
Prior art date
Application number
DK96937699T
Other languages
English (en)
Inventor
Azita Saleki-Gerhardt
R Keske Ernest
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK0858324T3 publication Critical patent/DK0858324T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96937699T 1995-11-01 1996-10-18 Fremgangsmåde til vandig granulering af clarithromycin DK0858324T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US715095P 1995-11-01 1995-11-01
US08/722,288 US5919489A (en) 1995-11-01 1996-10-09 Process for aqueous granulation of clarithromycin
PCT/US1996/016794 WO1997016174A1 (en) 1995-11-01 1996-10-18 Process for aqueous granulation of clarithromycin

Publications (1)

Publication Number Publication Date
DK0858324T3 true DK0858324T3 (da) 2003-09-29

Family

ID=26676595

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96937699T DK0858324T3 (da) 1995-11-01 1996-10-18 Fremgangsmåde til vandig granulering af clarithromycin

Country Status (13)

Country Link
US (1) US5919489A (da)
EP (1) EP0858324B1 (da)
JP (1) JP4334015B2 (da)
KR (1) KR100524202B1 (da)
AT (1) ATE241963T1 (da)
AU (1) AU706837B2 (da)
CA (1) CA2235607C (da)
DE (1) DE69628575T2 (da)
DK (1) DK0858324T3 (da)
ES (1) ES2200075T3 (da)
IL (1) IL123571A (da)
PT (1) PT858324E (da)
WO (1) WO1997016174A1 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551616B1 (en) 1997-04-11 2003-04-22 Abbott Laboratories Extended release formulations of erythromycin derivatives
US6010718A (en) * 1997-04-11 2000-01-04 Abbott Laboratories Extended release formulations of erythromycin derivatives
IN191239B (da) 1999-06-11 2003-10-11 Ranbaxy Lab Ltd
EP1194124B1 (en) * 1999-06-11 2003-09-03 Ranbaxy Laboratories Limited Taste masked compositions
EP1231896A4 (en) * 1999-11-16 2003-07-09 Ranbaxy Lab Ltd MASK TASTE ORAL COMPOSITIONS
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
SK13722002A3 (sk) * 2000-02-29 2003-08-05 Teva Pharmaceutical Industries Ltd. Spôsob prípravy klaritromycínu a klaritromycínového medziproduktu, v podstate prostého oxímu a farmaceutický prostriedok, ktorý ho obsahuje
ATE432691T1 (de) * 2000-03-28 2009-06-15 Sandoz Ag Geschmackmaskierte granulierte teilchen
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
DE10133546A1 (de) * 2001-07-11 2003-03-06 Petra Bastian Mischkomplexe zur Maskierung bitter schmeckender Substanzen
FR2827517B1 (fr) * 2001-07-23 2003-10-24 Bioalliance Pharma Systemes therapeutiques bioadhesifs a liberation prolongee
US20030039687A1 (en) * 2001-08-01 2003-02-27 Michael Corbo Taste masking composition
AU2003245504A1 (en) * 2002-06-14 2003-12-31 Andrx Corporation Pharmaceutical compositions for drugs having ph-dependentsolubility
US20060083759A1 (en) * 2002-07-17 2006-04-20 Aleksander Resman Stabilization of the profile of release of active substances from a formulation
EP1417958A1 (en) * 2002-11-08 2004-05-12 Pari GmbH Wet granulation process
CA2675724C (en) * 2003-06-16 2012-12-04 Andrx Pharmaceuticals, Llc Oral extended-release composition
WO2005009364A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533178C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258953B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
AU2004270170B2 (en) 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004273830B2 (en) 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
PL1691787T3 (pl) * 2003-12-04 2008-11-28 Pfizer Prod Inc Sposób wytwarzania farmaceutycznych systemów wielocząstkowych
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
KR20080064209A (ko) * 2003-12-04 2008-07-08 화이자 프로덕츠 인코포레이티드 바람직하게는 폴록사머와 글리세라이드를 함유하는다미립자 아지트로마이신 조성물의 제조를 위해 압출기를사용하는 분무응결 방법
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
JP2008505124A (ja) 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
CN1883456B (zh) * 2005-06-20 2010-12-15 常州市第四制药厂有限公司 掩味药物颗粒及其制备方法和用途
US20070015719A1 (en) * 2005-07-07 2007-01-18 Elan Pharma International Limited Nanoparticulate clarithromycin formulations
US20070048364A1 (en) * 2005-08-04 2007-03-01 Yingxu Peng Free flowing granules containing carbomer
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
EP1837020A1 (en) 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20070286903A1 (en) * 2006-06-13 2007-12-13 Becicka Brian T Composition and method for taste masking
EP2030613A1 (en) 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics
WO2012091039A1 (ja) * 2010-12-27 2012-07-05 富田製薬株式会社 粒子状製剤
CN102813633A (zh) * 2011-06-10 2012-12-12 塔科敏斯基制药厂波尔法合资公司 用湿法制粒制备包含大环内酯类抗生素的药物组合物的方法
RU2692469C1 (ru) * 2018-06-25 2019-06-25 ООО "Новые Антибиотики" Лекарственное средство для лечения и предупреждения возникновения осложнений, связанных с химиотерапией и рентгенотерапией, а также состояний, связанных с повышенной проницаемостью кишки
JP7442193B2 (ja) * 2018-08-10 2024-03-04 日本臓器製薬株式会社 粒状組成物及びその製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608278A (en) * 1983-06-22 1986-08-26 The Ohio State University Research Foundation Small particule formation and encapsulation
US4808411A (en) * 1987-06-05 1989-02-28 Abbott Laboratories Antibiotic-polymer compositions

Also Published As

Publication number Publication date
CA2235607A1 (en) 1997-05-09
ATE241963T1 (de) 2003-06-15
EP0858324A1 (en) 1998-08-19
JP4334015B2 (ja) 2009-09-16
AU706837B2 (en) 1999-06-24
ES2200075T3 (es) 2004-03-01
DE69628575D1 (de) 2003-07-10
JPH11514646A (ja) 1999-12-14
CA2235607C (en) 2003-05-13
EP0858324B1 (en) 2003-06-04
KR100524202B1 (ko) 2006-07-06
KR19990067265A (ko) 1999-08-16
DE69628575T2 (de) 2004-04-29
AU7517696A (en) 1997-05-22
US5919489A (en) 1999-07-06
MX9803480A (es) 1998-09-30
IL123571A (en) 2005-07-25
WO1997016174A1 (en) 1997-05-09
IL123571A0 (en) 1998-10-30
PT858324E (pt) 2003-10-31

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