DK0814843T3 - Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug - Google Patents

Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug

Info

Publication number
DK0814843T3
DK0814843T3 DK96910595T DK96910595T DK0814843T3 DK 0814843 T3 DK0814843 T3 DK 0814843T3 DK 96910595 T DK96910595 T DK 96910595T DK 96910595 T DK96910595 T DK 96910595T DK 0814843 T3 DK0814843 T3 DK 0814843T3
Authority
DK
Denmark
Prior art keywords
hapten
treatment
carrier conjugates
disclosed
conjugates
Prior art date
Application number
DK96910595T
Other languages
English (en)
Inventor
Philip A Swain
Victoria C Schad
Julia L Greenstein
Mark A Exley
Barbara S Fox
Stephen P Powers
Malcolm L Gefter
Thomas J Briner
Original Assignee
Xenova Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/563,673 external-priority patent/US5760184A/en
Application filed by Xenova Res Ltd filed Critical Xenova Res Ltd
Application granted granted Critical
Publication of DK0814843T3 publication Critical patent/DK0814843T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
DK96910595T 1995-03-31 1996-03-27 Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug DK0814843T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41497195A 1995-03-31 1995-03-31
US08/563,673 US5760184A (en) 1995-03-31 1995-11-28 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
PCT/US1996/004189 WO1996030049A2 (en) 1995-03-31 1996-03-27 Hapten-carrier conjugates for use in drug-abuse therapy

Publications (1)

Publication Number Publication Date
DK0814843T3 true DK0814843T3 (da) 2004-03-29

Family

ID=27022809

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96910595T DK0814843T3 (da) 1995-03-31 1996-03-27 Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug
DK03008324T DK1329226T3 (da) 1995-03-31 1996-03-27 Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03008324T DK1329226T3 (da) 1995-03-31 1996-03-27 Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug

Country Status (10)

Country Link
US (1) US6054127A (da)
EP (1) EP0814843B1 (da)
AT (2) ATE362380T1 (da)
AU (1) AU5374996A (da)
CA (1) CA2216658C (da)
DE (2) DE69630877T2 (da)
DK (2) DK0814843T3 (da)
ES (2) ES2287379T3 (da)
PT (1) PT814843E (da)
WO (1) WO1996030049A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773003A (en) * 1995-03-31 1998-06-30 Immulogic, Inc. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US20020032316A1 (en) * 1995-03-31 2002-03-14 Cantab Pharmaceuticals Research Limited Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5817770A (en) 1997-03-21 1998-10-06 Drug Abuse Sciences, Inc. Cocaethylene immunogens and antibodies
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US6232082B1 (en) 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
CA2403252A1 (en) 2000-03-15 2001-09-20 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
AU2002226055A1 (en) * 2000-12-07 2002-06-18 The Scripps Research Institute Cocaine haptens
EP1523334A2 (en) * 2002-07-18 2005-04-20 Cytos Biotechnology AG Hapten-carrier conjugates and uses thereof
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
MXPA04006617A (es) 2004-07-07 2006-01-12 Inst Nac De Psiquiatria Ramon Proceso para la preparacion y uso de una vacuna bivalente contra la adiccion a la morfina-heroina.
US20060024768A1 (en) * 2004-07-29 2006-02-02 Saladax Biomedical, Inc. Taxol immunoassay
EP1854478A1 (en) * 2006-05-12 2007-11-14 Cytos Biotechnology AG Nicotine-carrier vaccine formulation
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
EP2214672B1 (en) * 2007-10-18 2012-10-17 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
FR2952935B1 (fr) * 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
CN108409749B (zh) * 2018-01-30 2019-09-06 中国农业科学院蜜蜂研究所 钩吻素己半抗原和全抗原及其制备方法与应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375414A (en) * 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
US3766162A (en) * 1971-08-24 1973-10-16 Hoffmann La Roche Barbituric acid antigens and antibodies specific therefor
US3888886A (en) * 1972-06-08 1975-06-10 Mobil Oil Corp Oxidation of alkanes to maleic anhydride using promoted vanadium-phosphorus catalyst
US4045420A (en) * 1973-05-29 1977-08-30 Syva Company Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof
US4197237A (en) * 1973-06-01 1980-04-08 Syva Company Antibodies to nitrogen derivatives of benzoyl ecgonine antigenic conjugates thereof
US4207307A (en) * 1977-01-21 1980-06-10 Research Corporation Simultaneous immunoassay of multiple antigens and assay for cocaine metabolites
SU792869A1 (ru) * 1979-03-30 1982-03-30 Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений Способ получени конъюгированных антигенов барбитурова кислота-иммуногенный носитель
US4376825A (en) * 1979-05-07 1983-03-15 Syva Company Enzyme amplification compounds for assays for androgens
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
SU1123704A1 (ru) * 1983-04-08 1984-11-15 Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений Способ получени конъюгированных антигенов
US5019384A (en) * 1986-06-30 1991-05-28 Massachusetts Institute Of Technology Immunonodulating compositions and their use
US5229490A (en) * 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US4791067A (en) * 1987-06-25 1988-12-13 Fisher Scientific Co. Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent
DE3884731D1 (de) * 1987-10-09 1993-11-11 Ube Industries Monoklonaler Antikörper gegen Methamphetamin, seine Herstellung, Testverfahren und Testsatz für Methamphetamin.
AU634153B2 (en) * 1988-02-01 1993-02-18 Wyeth Holdings Corporation T-cell epitope as carriers molecule for conjugate vaccines
GB8812214D0 (en) * 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5026827A (en) * 1988-09-02 1991-06-25 Matsushita Electric Industrial Co., Ltd. Amphetamine-protein complex as immunogen for obtaining antibodies specific to methamphetamine
US5268276A (en) * 1988-09-16 1993-12-07 Jan Holmgren Recombinant systems for expression of cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
EP0363041A1 (en) * 1988-09-21 1990-04-11 Ube Industries, Ltd. Monoclonal antibody to morphine, preparation of monoclonal antibody, assaying kit and assaying method of morphine
ATE154135T1 (de) * 1989-03-10 1997-06-15 Hoffmann La Roche Reagenzien zum nachweis von drogen
GB8924438D0 (en) * 1989-10-31 1989-12-20 Hoffmann La Roche Vaccine composition
US5096838A (en) * 1989-11-27 1992-03-17 Abbott Laboratories Barbiturate assay compositions and methods
CH678394A5 (da) * 1990-08-22 1991-09-13 Cerny Erich H
JPH04182499A (ja) * 1990-11-14 1992-06-30 Matsushita Electric Ind Co Ltd エクゴニン・タンパク質コンジュゲート及びその誘導体
US5233042A (en) * 1991-12-16 1993-08-03 Biosite Diagnostics, Inc. Cocaine derivatives
US5283066A (en) * 1992-02-19 1994-02-01 Development Center For Biotechnology Method of stimulating an immune response by using a hapten
US5302715A (en) * 1992-04-06 1994-04-12 Biosite Diagnostics, Inc. Benzodiazepine derivatives
WO1993023076A1 (en) * 1992-05-20 1993-11-25 The Johns-Hopkins University Alternative receptor therapy
DE69332637T2 (de) * 1993-03-04 2003-10-23 Matsushita Electric Ind Co Ltd Kokainderivat,Proteinkonjugat,davon,einen monoklonalen Antikörper produzierende Hybridom-Zellinie, Verfahren zur Herstellung der Hybridom-Zellinie und des monoklonalen Antikörpers
EP0724588B1 (en) * 1993-09-17 1999-11-10 Smithkline Beecham Corporation Drug binding protein
WO1995027786A1 (en) * 1994-04-08 1995-10-19 Immulogic Pharmaceutical Corporation Pharmaceutical formulations for treating japanese cedar pollen allergy

Also Published As

Publication number Publication date
US6054127A (en) 2000-04-25
ATE254930T1 (de) 2003-12-15
AU5374996A (en) 1996-10-16
EP0814843A2 (en) 1998-01-07
PT814843E (pt) 2004-04-30
EP0814843B1 (en) 2003-11-26
WO1996030049A2 (en) 1996-10-03
DE69630877T2 (de) 2004-11-11
CA2216658C (en) 2008-05-13
ES2210356T3 (es) 2004-07-01
DE69637089T2 (de) 2008-01-17
DE69637089D1 (de) 2007-06-28
CA2216658A1 (en) 1996-10-03
ES2287379T3 (es) 2007-12-16
WO1996030049A3 (en) 1997-03-06
ATE362380T1 (de) 2007-06-15
DK1329226T3 (da) 2007-09-24
DE69630877D1 (de) 2004-01-08

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