DK0808303T3 - 5-(4-subst.-piperidinyl-1)-3-aryl-pentansyrederivater som tachykininreceptorantagonister - Google Patents
5-(4-subst.-piperidinyl-1)-3-aryl-pentansyrederivater som tachykininreceptorantagonisterInfo
- Publication number
- DK0808303T3 DK0808303T3 DK96901904T DK96901904T DK0808303T3 DK 0808303 T3 DK0808303 T3 DK 0808303T3 DK 96901904 T DK96901904 T DK 96901904T DK 96901904 T DK96901904 T DK 96901904T DK 0808303 T3 DK0808303 T3 DK 0808303T3
- Authority
- DK
- Denmark
- Prior art keywords
- subst
- piperidinyl
- aryl
- acid derivatives
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9502644.9A GB9502644D0 (en) | 1995-02-10 | 1995-02-10 | Heterocyclic derivatives |
| PCT/GB1996/000259 WO1996024582A1 (en) | 1995-02-10 | 1996-02-08 | 5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives as tachykinin receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0808303T3 true DK0808303T3 (da) | 2001-09-10 |
Family
ID=10769412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96901904T DK0808303T3 (da) | 1995-02-10 | 1996-02-08 | 5-(4-subst.-piperidinyl-1)-3-aryl-pentansyrederivater som tachykininreceptorantagonister |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0808303B1 (de) |
| JP (2) | JPH10513191A (de) |
| KR (1) | KR19980702030A (de) |
| CN (1) | CN1181069A (de) |
| AT (1) | ATE202342T1 (de) |
| AU (1) | AU714289B2 (de) |
| CA (1) | CA2209832A1 (de) |
| DE (1) | DE69613457T2 (de) |
| DK (1) | DK0808303T3 (de) |
| ES (1) | ES2159717T3 (de) |
| FI (1) | FI973283A (de) |
| GB (2) | GB9502644D0 (de) |
| GR (1) | GR3036639T3 (de) |
| IL (1) | IL117093A0 (de) |
| MX (1) | MX9705801A (de) |
| NO (1) | NO973652L (de) |
| NZ (1) | NZ300994A (de) |
| PT (1) | PT808303E (de) |
| WO (1) | WO1996024582A1 (de) |
| ZA (1) | ZA961069B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
| GB9523526D0 (en) * | 1995-11-17 | 1996-01-17 | Zeneca Ltd | Therapeutic compounds |
| US6136827A (en) * | 1997-07-25 | 2000-10-24 | Merck & Co., Inc. | Cyclic amine modulations of chemokine receptor activity |
| AU8576098A (en) * | 1997-07-25 | 1999-02-16 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| HUP0102531A3 (en) * | 1998-05-15 | 2003-01-28 | Aventis Pharmaceuticals Inc Br | Carboxy substituted carboxamide derivatives and their use as tachykinin receptor antagonists |
| US6316445B1 (en) | 1998-05-15 | 2001-11-13 | Aventis Pharmaceuticals Inc. | Carboxy substituted acylic carboxamide derivatives |
| US7217714B1 (en) * | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
| EP1013276A1 (de) * | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkane als CCR5-Modulatoren |
| PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| GB0215392D0 (en) * | 2002-07-03 | 2002-08-14 | Glaxo Group Ltd | Chemical compounds |
| TW200508221A (en) | 2003-06-13 | 2005-03-01 | Astrazeneca Ab | New azetidine compounds |
| EP1786816A4 (de) | 2003-09-10 | 2009-11-04 | Virochem Pharma Inc | Spirohydantoinverbindungen und -verfahren zur modulation von chemokin-rezeptoraktivität |
| WO2006083711A1 (en) * | 2005-02-01 | 2006-08-10 | Eli Lilly And Company | Tachykinin receptor antagonists |
| EP1943250A1 (de) | 2005-09-09 | 2008-07-16 | Euro-Celtique S.A. | Kondensierte und spirocyclische verbindungen und deren verwendung |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| JP2009508944A (ja) * | 2005-09-21 | 2009-03-05 | アストラゼネカ・アクチエボラーグ | Ｎｋ−３受容体リガンドとしてのｎ−オキソ複素環及びｎ−オキソ−アルキルキノリン−４−カルボキシアミド類 |
| AR057828A1 (es) | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
| US8106208B2 (en) | 2006-05-18 | 2012-01-31 | Albireo Ab | Benzamide compounds that act as NK receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL173848C (nl) * | 1970-06-01 | 1984-03-16 | Janssen Pharmaceutica Nv | Werkwijze ter bereiding van 2.2-diaryl 4-piperidino butyramiden; werkwijze ter bereiding van therapeutisch werkzame preparaten en de door toepassing daarvan verkregen gevormde voortbrengselen. |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| GB9321557D0 (en) * | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
| EP0702681A1 (de) * | 1993-06-07 | 1996-03-27 | Merck & Co. Inc. | Spiro-substituierte azaringe als neurokinin antagonisten |
| US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
-
1995
- 1995-02-10 GB GBGB9502644.9A patent/GB9502644D0/en active Pending
-
1996
- 1996-01-29 GB GBGB9601722.3A patent/GB9601722D0/en active Pending
- 1996-02-08 EP EP96901904A patent/EP0808303B1/de not_active Expired - Lifetime
- 1996-02-08 DK DK96901904T patent/DK0808303T3/da active
- 1996-02-08 MX MX9705801A patent/MX9705801A/es unknown
- 1996-02-08 CA CA002209832A patent/CA2209832A1/en not_active Abandoned
- 1996-02-08 NZ NZ300994A patent/NZ300994A/en unknown
- 1996-02-08 WO PCT/GB1996/000259 patent/WO1996024582A1/en not_active Application Discontinuation
- 1996-02-08 JP JP8524072A patent/JPH10513191A/ja active Pending
- 1996-02-08 AT AT96901904T patent/ATE202342T1/de not_active IP Right Cessation
- 1996-02-08 KR KR1019970705425A patent/KR19980702030A/ko not_active Application Discontinuation
- 1996-02-08 DE DE69613457T patent/DE69613457T2/de not_active Expired - Fee Related
- 1996-02-08 AU AU46297/96A patent/AU714289B2/en not_active Ceased
- 1996-02-08 ES ES96901904T patent/ES2159717T3/es not_active Expired - Lifetime
- 1996-02-08 PT PT96901904T patent/PT808303E/pt unknown
- 1996-02-08 CN CN96193228A patent/CN1181069A/zh active Pending
- 1996-02-09 IL IL11709396A patent/IL117093A0/xx unknown
- 1996-02-09 ZA ZA961069A patent/ZA961069B/xx unknown
-
1997
- 1997-08-08 FI FI973283A patent/FI973283A/fi unknown
- 1997-08-08 NO NO973652A patent/NO973652L/no not_active Application Discontinuation
-
2001
- 2001-09-18 GR GR20010401497T patent/GR3036639T3/el not_active IP Right Cessation
-
2007
- 2007-12-26 JP JP2007341959A patent/JP2008138007A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA961069B (en) | 1996-08-12 |
| FI973283A (fi) | 1997-10-07 |
| AU4629796A (en) | 1996-08-27 |
| ATE202342T1 (de) | 2001-07-15 |
| JPH10513191A (ja) | 1998-12-15 |
| GR3036639T3 (en) | 2001-12-31 |
| EP0808303A1 (de) | 1997-11-26 |
| DE69613457D1 (de) | 2001-07-26 |
| NO973652L (no) | 1997-10-08 |
| DE69613457T2 (de) | 2002-04-18 |
| AU714289B2 (en) | 1999-12-23 |
| KR19980702030A (ko) | 1998-07-15 |
| FI973283A0 (fi) | 1997-08-08 |
| NO973652D0 (no) | 1997-08-08 |
| IL117093A0 (en) | 1996-06-18 |
| JP2008138007A (ja) | 2008-06-19 |
| PT808303E (pt) | 2001-11-30 |
| MX9705801A (es) | 1997-10-31 |
| NZ300994A (en) | 1999-10-28 |
| CA2209832A1 (en) | 1996-08-15 |
| GB9502644D0 (en) | 1995-03-29 |
| EP0808303B1 (de) | 2001-06-20 |
| ES2159717T3 (es) | 2001-10-16 |
| GB9601722D0 (en) | 1996-03-27 |
| CN1181069A (zh) | 1998-05-06 |
| WO1996024582A1 (en) | 1996-08-15 |
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