DK0800578T3 - Rekombinant monoklonalt anti-idiotype antistof 3H1 - Google Patents

Rekombinant monoklonalt anti-idiotype antistof 3H1

Info

Publication number
DK0800578T3
DK0800578T3 DK95944450T DK95944450T DK0800578T3 DK 0800578 T3 DK0800578 T3 DK 0800578T3 DK 95944450 T DK95944450 T DK 95944450T DK 95944450 T DK95944450 T DK 95944450T DK 0800578 T3 DK0800578 T3 DK 0800578T3
Authority
DK
Denmark
Prior art keywords
monoclonal anti
idiotype antibody
cea
recombinant monoclonal
provides
Prior art date
Application number
DK95944450T
Other languages
Danish (da)
English (en)
Inventor
Malaya Chatterjee
Heinz Kohler
Sunil K Chatterjee
Kenneth A Foon
Original Assignee
Univ Kentucky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky filed Critical Univ Kentucky
Application granted granted Critical
Publication of DK0800578T3 publication Critical patent/DK0800578T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK95944450T 1994-12-28 1995-12-28 Rekombinant monoklonalt anti-idiotype antistof 3H1 DK0800578T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36548494A 1994-12-28 1994-12-28
PCT/US1995/017103 WO1996020277A2 (en) 1994-12-28 1995-12-28 Recombinant monoclonal anti-idiotype antibody 3h1 sequences relating to human carcinoembryonic antigen

Publications (1)

Publication Number Publication Date
DK0800578T3 true DK0800578T3 (da) 2003-08-11

Family

ID=23439088

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95944450T DK0800578T3 (da) 1994-12-28 1995-12-28 Rekombinant monoklonalt anti-idiotype antistof 3H1
DK95944582T DK0796280T3 (da) 1994-12-28 1995-12-28 Murint monoklonalt anti-idiotypisk antistof 3H1

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK95944582T DK0796280T3 (da) 1994-12-28 1995-12-28 Murint monoklonalt anti-idiotypisk antistof 3H1

Country Status (12)

Country Link
US (3) US5977315A (es)
EP (3) EP0796280B1 (es)
JP (2) JPH11500607A (es)
AT (2) ATE235514T1 (es)
AU (2) AU704829B2 (es)
CA (2) CA2209360C (es)
DE (2) DE69530415T2 (es)
DK (2) DK0800578T3 (es)
ES (2) ES2196098T3 (es)
MX (2) MX9704897A (es)
PT (2) PT800578E (es)
WO (2) WO1996020219A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE235514T1 (de) * 1994-12-28 2003-04-15 Univ Kentucky Monoklonaler anti-idiotypischer antikörper 3h1 aus maus
US20020041872A1 (en) 1996-04-12 2002-04-11 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US6235280B1 (en) * 1996-04-12 2001-05-22 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US20080220012A1 (en) * 1996-05-15 2008-09-11 Ragupathy Madiyalakan Therapeutic Compositions that alter the immune response
WO1997042973A1 (en) * 1996-05-15 1997-11-20 Altarex, Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US20020098190A1 (en) * 1997-06-13 2002-07-25 Malaya Chatterjee Compositions and methods for treating tumors bearing HMFG and CEA antigens
NZ501990A (en) * 1997-07-08 2002-09-27 Viventia Biotech Inc Compositions containing antigen-binding fragments that recognise the antigen recognised by a recombinant 4B5 antibody
US7569674B2 (en) 1998-05-04 2009-08-04 Innexus Biotechnology International Limited Autophilic antibodies
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
AT409086B (de) * 1999-11-16 2002-05-27 Igeneon Krebs Immuntherapie Neue verwendung von antikörpern als impfstoffe
US6774209B1 (en) * 2000-04-03 2004-08-10 Dyax Corp. Binding peptides for carcinoembryonic antigen (CEA)
WO2001078626A1 (en) 2000-04-13 2001-10-25 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
DE20105649U1 (de) * 2001-03-30 2001-08-16 Wang Ming Theng Kettenzahnrad und Ratschenanordnung geringer Reibung für die rückwärtige Nabe eines Zweirades
US8029803B2 (en) * 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8025873B2 (en) * 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
AT500650B1 (de) * 2003-04-17 2009-11-15 Altropus Gmbh Immunogener rekombinanter antikörper
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
RU2371313C2 (ru) * 2004-08-05 2009-10-27 Эр энд Ди Грин Материалз, Эл-Эл-Си Способ низкотемпературного формования для изготовления твердых биоразлагаемых изделий
JP2008521820A (ja) * 2004-11-24 2008-06-26 ヘルス リサーチ インコーポレイテッド 免疫原性ペプチドを同定および設計するための方法
CN101300355A (zh) * 2005-10-13 2008-11-05 威瑞克斯医药公司 包含丙型肝炎病毒多肽和用于引起免疫应答的Fc片段的嵌合抗原
JP5165672B2 (ja) * 2006-03-29 2013-03-21 キングス カレッジ ロンドン Ｔｓｈｒに対するアゴニスト抗体
TWI434855B (zh) * 2006-11-21 2014-04-21 Hoffmann La Roche 結合物及其在免疫分析中作為參考標準之用途
MX2010004910A (es) 2007-11-08 2010-05-14 Neogenix Oncology Inc Anticuerpos monoclonales recombinantes y antigenos correspondientes para canceres colonico y pancreatico.
US8093018B2 (en) * 2008-05-20 2012-01-10 Otsuka Pharmaceutical Co., Ltd. Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
NZ599456A (en) * 2009-10-26 2014-06-27 Nestec Sa Assays for the detection of anti-tnf drugs and autoantibodies
SG189391A1 (en) 2010-10-18 2013-05-31 Nestec Sa Methods for determining anti-drug antibody isotypes
AU2012278802B2 (en) 2011-07-06 2015-11-26 Société des Produits Nestlé S.A. Assays for detecting neutralizing autoantibodies to biologic therapy with TNF alpha
MA40094B1 (fr) * 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
KR20170091717A (ko) 2014-12-05 2017-08-09 네스텍 소시에테아노님 환자 샘플 중 생물제제의 검출을 위한 간접적 균질 이동성 변화 검정
EP3774861A1 (en) 2018-03-28 2021-02-17 Bristol-Myers Squibb Company Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
JPS54140710A (en) 1978-03-10 1979-11-01 Mitsui Toatsu Chem Inc Anti-tumor substance and its preparation
JPS56145222A (en) * 1980-04-28 1981-11-11 Toshiyuki Hamaoka Improved antibody and its preparation
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US5053224A (en) 1983-11-07 1991-10-01 Hilary Koprowski Induction of antibody response to solid tumors with anti-idiotype antibodies
EP0291636A1 (en) 1983-11-07 1988-11-23 The Wistar Institute Immune response to viruses induced by anti-idiotype antibodies
US4828991A (en) * 1984-01-31 1989-05-09 Akzo N.V. Tumor specific monoclonal antibodies
US5180814A (en) 1984-01-31 1993-01-19 Akzo N.V. Tumor specific monoclonal antibodies
US5106738A (en) * 1984-01-31 1992-04-21 Akzo Nv Tumor specific monoclonal antibodies
US5171568A (en) * 1984-04-06 1992-12-15 Chiron Corporation Recombinant herpes simplex gb-gd vaccine
US4722840A (en) 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US5160723A (en) * 1985-04-19 1992-11-03 Sloan-Kettering Institute For Cancer Research Method of imaging colorectal carcinoma lesion and composition for use therein
GB2202017A (en) * 1987-03-07 1988-09-14 Alvan Michael Judson Anti-lock electric braking
US5057540A (en) * 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
JP2517343B2 (ja) 1988-01-26 1996-07-24 富士写真フイルム株式会社 熱現像感光材料
JPH01207920A (ja) 1988-02-16 1989-08-21 Oki Electric Ind Co Ltd ＩｎＰ半導体薄膜の製造方法
GB8812137D0 (en) 1988-05-23 1988-06-29 Imp Cancer Res Tech Antibodies
US5183756A (en) * 1988-08-19 1993-02-02 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibody (D612) having selective reactivity for gastrointestinal caricinomas and method for employing the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5077284A (en) 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5407684A (en) 1988-12-30 1995-04-18 Virginia Commonwealth University Use of DHEA as a medicinal
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5244801A (en) 1989-12-28 1993-09-14 Martin Tobi Process for producing monoclonal antibodies which specifically bind to benign colonic adenomatous polyps of human origin and hybridomas and monoclonal antibodies produced by said process
ATE149841T1 (de) * 1990-01-26 1997-03-15 Immunomedics Inc Impfstoffe gegen krebs und infektionskrankheiten
US5200316A (en) 1990-02-15 1993-04-06 Miles Inc. Immunoassay methods using noncross reactive cea gene family members antibodies
DE69124372T2 (de) * 1990-05-10 1997-08-07 Dana Farber Cancer Inst Inc Erhöhung der assoziation exogener peptide mit mhci-molekülen auf zellen des immunsystems
US5608039A (en) * 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
GB9105992D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
AU2690192A (en) 1991-09-19 1993-04-27 Lionel A. Manson Tumor immunotherapy utilizing a method of overcoming the resistance of a progressively growing tumor
US5227471A (en) 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
JPH08502954A (ja) 1992-08-31 1996-04-02 ジェナー テクノロジーズ 抗−イディオタイプ抗体を用いた抗腫瘍ｔ細胞応答の刺激
ATE235514T1 (de) * 1994-12-28 2003-04-15 Univ Kentucky Monoklonaler anti-idiotypischer antikörper 3h1 aus maus

Also Published As

Publication number Publication date
AU717779C (en) 2002-12-05
DK0796280T3 (da) 2003-04-22
AU704829B2 (en) 1999-05-06
MX9704898A (es) 1998-06-28
DE69530107T2 (de) 2003-10-16
JPH10511846A (ja) 1998-11-17
US5977315A (en) 1999-11-02
CA2209172C (en) 2007-04-10
CA2209360C (en) 2010-07-06
EP0800578B1 (en) 2003-04-16
DE69530415T2 (de) 2004-02-12
WO1996020219A2 (en) 1996-07-04
EP0800578A2 (en) 1997-10-15
JPH11500607A (ja) 1999-01-19
PT800578E (pt) 2003-09-30
ATE237687T1 (de) 2003-05-15
ES2196098T3 (es) 2003-12-16
DE69530107D1 (de) 2003-04-30
EP0796280B1 (en) 2003-03-26
CA2209360A1 (en) 1996-07-04
WO1996020219A3 (en) 1996-09-06
EP1298144A2 (en) 2003-04-02
ES2197217T3 (es) 2004-01-01
AU4649896A (en) 1996-07-19
CA2209172A1 (en) 1996-07-04
PT796280E (pt) 2003-08-29
EP0796280A2 (en) 1997-09-24
AU717779B2 (en) 2000-03-30
US7090842B1 (en) 2006-08-15
MX9704897A (es) 1998-06-28
DE69530415D1 (de) 2003-05-22
EP1298144A3 (en) 2006-05-31
WO1996020277A3 (en) 1996-09-06
AU4692796A (en) 1996-07-19
ATE235514T1 (de) 2003-04-15
US20010047083A1 (en) 2001-11-29
WO1996020277A2 (en) 1996-07-04

Similar Documents

Publication Publication Date Title
DK0800578T3 (da) Rekombinant monoklonalt anti-idiotype antistof 3H1
DE3574730D1 (de) Monoklonaler antikoerper gegen ein humanes tumor-karzinom-assoziiertes antigen.
ATE303160T1 (de) Impfstoff gegen prostatakrebs
DE3783277D1 (de) Monoklonaler antikoerper gegen humanes lungenkarzinom.
DE69329621T2 (de) MONOKLONALE ANTIKöRPER GEGEN DEFINIIERTE REGIONEN DES T-ZELL-ANTIGENREZEPTORS
DE69635843D1 (de) Monoklonaler anti-idiotypischer antikörper 11d10 aus der maus und methoden zu dessen verwendung
OA08485A (fr) Monoclonal antibodies and antigen for human non-small cell lung carcinoma and certain other human carcinomas.
ITRM920457A0 (it) Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteinaumana.
DE3586216D1 (de) Brusttumorassoziiertes antigen und monoklonale antikoerper dazu.
DK191989D0 (da) Tumor-associeret glycoproteinantigen, antistoffer mod antigenet samt hybridoma-cellelinie, der producerer antistofferne
TR200103432T2 (tr) Engelleyici monoklonal VLA-1 antikoru ve enflamasyonlu hastalıkların tedavisinde kullanımı.
ID20117A (id) Antibodi anti-fas
NO883501D0 (no) Slekt-spesifikt listeria-antigen identifisert med monoklonale antistoffer.
EP0215131A4 (en) ANTIGEN E87Ag OF PSEUDOMONAS AERUGINOSE, MONOCLONAL ANTIBODIES AGAINST THIS ANTIGEN AND HYBRIDOMA.
DE3785795D1 (de) Monoklonale anti-menschliche magenkrebs-antikoerper.
DE3580482D1 (de) Monoklonale antikoerper und immunisierung damit.
DK102589A (da) Antigen, der genkendes af mca 16-88
ATE359091T1 (de) Monoklonaler antikörper gegen menschlische nierenkarzinomzellen
FI924576A0 (fi) Ctaa 28a32, antigen identiefierad av mca 28a32
MX9202642A (es) Anticuerpos monoclonales y antigeno para melanoma humano.
ATE263784T1 (de) Anti-megakaryozyten monoklonaler antikörper 97a6
DK182188A (da) Humant tumorassocieret antigen
ATE58173T1 (de) Monoklonale antikoerper und immunisierung damit.
NO960683L (no) Monoklonalt antistoff som gjenkjenner interstitialcelle-overflateantigen
IL127249A0 (en) Human monoclonal antibodies to the hepatitis b surface antigen