DK0784055T3 - Pyrimidinylpyrazolderivater - Google Patents
PyrimidinylpyrazolderivaterInfo
- Publication number
- DK0784055T3 DK0784055T3 DK95932229T DK95932229T DK0784055T3 DK 0784055 T3 DK0784055 T3 DK 0784055T3 DK 95932229 T DK95932229 T DK 95932229T DK 95932229 T DK95932229 T DK 95932229T DK 0784055 T3 DK0784055 T3 DK 0784055T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- hydrogen atom
- chem
- formula
- pyrimidinylpyrazole
- Prior art date
Links
- BWIHJLOBZMKPKS-UHFFFAOYSA-N 2-(1h-pyrazol-5-yl)pyrimidine Chemical class N1C=CC(C=2N=CC=CN=2)=N1 BWIHJLOBZMKPKS-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Photoreceptors In Electrophotography (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22942294 | 1994-09-26 | ||
| JP13501095 | 1995-06-01 | ||
| PCT/JP1995/001934 WO1996010024A1 (fr) | 1994-09-26 | 1995-09-25 | Derive pyrimidinylpyrazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0784055T3 true DK0784055T3 (da) | 2003-06-02 |
Family
ID=26468965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95932229T DK0784055T3 (da) | 1994-09-26 | 1995-09-25 | Pyrimidinylpyrazolderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5852019A (cs) |
| EP (1) | EP0784055B1 (cs) |
| KR (1) | KR100388568B1 (cs) |
| CN (1) | CN1071754C (cs) |
| AT (1) | ATE232528T1 (cs) |
| CA (1) | CA2201110A1 (cs) |
| DE (2) | DE69529619D1 (cs) |
| DK (1) | DK0784055T3 (cs) |
| ES (1) | ES2192584T3 (cs) |
| FI (1) | FI971227L (cs) |
| NO (1) | NO313196B1 (cs) |
| TW (1) | TW312694B (cs) |
| WO (1) | WO1996010024A1 (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| CA2278677A1 (en) * | 1997-01-27 | 1998-07-30 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| WO2000005230A1 (en) * | 1998-07-24 | 2000-02-03 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives and salts thereof |
| AU3078000A (en) * | 1999-01-25 | 2000-08-07 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compounds and antitumor agents containing the same as the active ingredient |
| CN1310907C (zh) * | 2001-04-27 | 2007-04-18 | 全药工业株式会社 | 杂环化合物和以其为有效成分的抗肿瘤药 |
| WO2003011837A1 (en) * | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| FR2850379B1 (fr) * | 2003-01-28 | 2006-11-17 | Aventis Pharma Sa | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| US20050130989A1 (en) * | 2003-01-28 | 2005-06-16 | Aventis Pharma S. A. | N-arylheteroaromatic products compositions containing them and use thereof |
| BRPI0407088A (pt) * | 2003-01-28 | 2006-01-24 | Aventis Pharma Sa | Produtos n-aril-heteroaromáticos, composições contendo os mesmos e seu uso |
| US7223759B2 (en) * | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
| CN100532380C (zh) * | 2004-03-31 | 2009-08-26 | 全药工业株式会社 | 杂环化合物和以其作为有效成分的抗恶性肿瘤药 |
| KR101296884B1 (ko) | 2005-03-11 | 2013-08-14 | 젠야쿠코교가부시키가이샤 | 활성 성분으로서 헤테로시클릭 화합물을 포함하는 면역억제제 및 항암제 |
| US20070244110A1 (en) * | 2006-04-14 | 2007-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Treatment of prostate cancer, melanoma or hepatic cancer |
| ES2430821T3 (es) | 2006-10-10 | 2013-11-21 | Amgen Inc. | Compuestos de N-arilpirazol para usar contra la diabetes |
| EP3285581B1 (en) | 2015-03-26 | 2021-08-11 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| JP6896715B2 (ja) | 2015-09-30 | 2021-06-30 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ヴィッセンシャフテン エーファウ −ジェネラルフェルヴァルトゥング | セピアプテリン還元酵素としてのヘテロアリール誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
| JPS4842072A (cs) * | 1971-09-29 | 1973-06-19 | ||
| JPS61129129A (ja) * | 1984-11-28 | 1986-06-17 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| US5102893A (en) * | 1986-07-07 | 1992-04-07 | Warner-Lambert Company | Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
-
1995
- 1995-09-19 TW TW084109880A patent/TW312694B/zh active
- 1995-09-25 DE DE69529619A patent/DE69529619D1/de not_active Expired - Fee Related
- 1995-09-25 WO PCT/JP1995/001934 patent/WO1996010024A1/ja not_active Ceased
- 1995-09-25 US US08/821,076 patent/US5852019A/en not_active Expired - Fee Related
- 1995-09-25 FI FI971227A patent/FI971227L/fi unknown
- 1995-09-25 AT AT95932229T patent/ATE232528T1/de not_active IP Right Cessation
- 1995-09-25 KR KR1019970701964A patent/KR100388568B1/ko not_active Expired - Fee Related
- 1995-09-25 DK DK95932229T patent/DK0784055T3/da active
- 1995-09-25 ES ES95932229T patent/ES2192584T3/es not_active Expired - Lifetime
- 1995-09-25 DE DE69529619T patent/DE69529619T4/de not_active Expired - Lifetime
- 1995-09-25 CA CA002201110A patent/CA2201110A1/en not_active Abandoned
- 1995-09-25 CN CN95196449A patent/CN1071754C/zh not_active Expired - Fee Related
- 1995-09-25 EP EP95932229A patent/EP0784055B1/en not_active Expired - Lifetime
-
1997
- 1997-03-24 NO NO19971384A patent/NO313196B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW312694B (cs) | 1997-08-11 |
| KR100388568B1 (ko) | 2003-10-04 |
| FI971227A0 (fi) | 1997-03-24 |
| HK1001396A1 (en) | 1998-06-19 |
| EP0784055A1 (en) | 1997-07-16 |
| KR970706275A (ko) | 1997-11-03 |
| NO313196B1 (no) | 2002-08-26 |
| CN1071754C (zh) | 2001-09-26 |
| DE69529619T2 (de) | 2003-12-18 |
| EP0784055B1 (en) | 2003-02-12 |
| CA2201110A1 (en) | 1996-04-04 |
| ATE232528T1 (de) | 2003-02-15 |
| DE69529619D1 (en) | 2003-03-20 |
| ES2192584T3 (es) | 2003-10-16 |
| NO971384L (no) | 1997-05-23 |
| NO971384D0 (no) | 1997-03-24 |
| US5852019A (en) | 1998-12-22 |
| CN1166833A (zh) | 1997-12-03 |
| DE69529619T4 (de) | 2005-01-27 |
| FI971227A7 (fi) | 1997-05-23 |
| FI971227L (fi) | 1997-05-23 |
| EP0784055A4 (en) | 1998-01-07 |
| WO1996010024A1 (fr) | 1996-04-04 |
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