DK0768890T3 - Metoder til modulering af T-cellereaktioner ved manipulation af en fælles cytokinreceptor-gamma-kæde - Google Patents
Metoder til modulering af T-cellereaktioner ved manipulation af en fælles cytokinreceptor-gamma-kædeInfo
- Publication number
- DK0768890T3 DK0768890T3 DK95924766T DK95924766T DK0768890T3 DK 0768890 T3 DK0768890 T3 DK 0768890T3 DK 95924766 T DK95924766 T DK 95924766T DK 95924766 T DK95924766 T DK 95924766T DK 0768890 T3 DK0768890 T3 DK 0768890T3
- Authority
- DK
- Denmark
- Prior art keywords
- gamma chain
- receptor
- methods
- cytokine receptor
- interleukin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2046—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/270,152 US6576236B1 (en) | 1994-07-01 | 1994-07-01 | Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain |
PCT/US1995/008320 WO1996001122A1 (en) | 1994-07-01 | 1995-06-30 | Methods for modulating t cell responses by manipulating a common cytokine receptor gamma chain |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0768890T3 true DK0768890T3 (da) | 2008-06-09 |
Family
ID=23030131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95924766T DK0768890T3 (da) | 1994-07-01 | 1995-06-30 | Metoder til modulering af T-cellereaktioner ved manipulation af en fælles cytokinreceptor-gamma-kæde |
Country Status (10)
Country | Link |
---|---|
US (2) | US6576236B1 (de) |
EP (2) | EP1958966A2 (de) |
JP (2) | JPH10502372A (de) |
AT (1) | ATE386537T1 (de) |
AU (1) | AU2915295A (de) |
CA (1) | CA2194239A1 (de) |
DE (1) | DE69535713T2 (de) |
DK (1) | DK0768890T3 (de) |
ES (1) | ES2299174T3 (de) |
WO (1) | WO1996001122A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3362192B2 (ja) * | 1994-12-06 | 2003-01-07 | 味の素株式会社 | 検査方法及び検査薬 |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
CA2220226C (en) * | 1995-05-04 | 2008-10-21 | Carl H. June | Improved methods for transfecting t cells |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
DE59605711D1 (de) * | 1995-10-11 | 2000-09-14 | Arteva Tech Sarl | Schwerentflammbare Sicherheitsgurte enthaltend phosphor-modifizierte Polyesterfasern |
FR2745185B1 (fr) * | 1996-02-28 | 1998-05-15 | Sanofi Sa | Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant |
ATE476496T1 (de) * | 1996-03-04 | 2010-08-15 | Calyx Bio Ventures Inc | Modifizierte schnellvermehrungsmethode ('modified-rem') zur in vitro vermehrung von t-lymphozyten |
US5807743A (en) * | 1996-12-03 | 1998-09-15 | Ribozyme Pharmaceuticals, Inc. | Interleukin-2 receptor gamma-chain ribozymes |
JP2001511649A (ja) * | 1997-02-07 | 2001-08-14 | トーマス・ジェファーソン・ユニバーシティ | サイトカインレセプターガンマ鎖のペプチド模倣物 |
DE19721099C2 (de) * | 1997-05-20 | 1999-12-02 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten |
DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
AU2001234784A1 (en) * | 2000-02-04 | 2001-08-14 | Bioseek | Compositions and methods for reducing autoimmunity |
MXPA03008959A (es) * | 2001-04-02 | 2004-10-15 | Wyeth Corp | Pd-1, un receptor para b7-4 y sus usos. |
EP1663197B1 (de) | 2003-09-09 | 2007-12-05 | Fumapharm AG | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
AU2007214426A1 (en) * | 2006-02-16 | 2007-08-23 | Nascent Biologics, Inc. | Methods for improving immune function and methods for prevention or treatment of disease in a mammalian subject |
HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
JP2016523102A (ja) * | 2013-06-24 | 2016-08-08 | アントフロゲネシス コーポレーション | T細胞を増殖させるための方法 |
EA202192090A1 (ru) | 2019-02-01 | 2021-10-20 | Регенерон Фармасьютикалз, Инк. | Антигенсвязывающие белки против гамма-цепи рецептора il2 |
Family Cites Families (32)
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (de) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
US5017691A (en) * | 1986-07-03 | 1991-05-21 | Schering Corporation | Mammalian interleukin-4 |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP1892296A1 (de) | 1988-09-02 | 2008-02-27 | Dyax Corporation | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
IL92382A (en) | 1988-11-23 | 1994-12-29 | Univ Michigan | Use of a ligand specific for CD28 in the manufacture of medicament |
WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
WO1991001145A1 (en) * | 1989-07-25 | 1991-02-07 | Regents Of The University Of Minnesota | Pokeweed antiviral protein - monoclonal antibody conjugates |
EP1690935A3 (de) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Bildung von xenogenen Antikörpern |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5229115A (en) * | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
CA2090473A1 (en) | 1990-08-29 | 1992-03-01 | Robert M. Kay | Homologous recombinatin in mammalian cells |
DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
AU661979B2 (en) * | 1990-09-06 | 1995-08-17 | Schering Corporation | Use of IL-4 to treat solid tumors |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
JP4146512B2 (ja) | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | 小型タンパク質 |
US5474769A (en) * | 1991-03-08 | 1995-12-12 | Sterling Winthrop Inc. | Treatment of microbial infection by monocyte stimulation with interleukin-7 |
CA2108147C (en) | 1991-04-10 | 2009-01-06 | Angray Kang | Heterodimeric receptor libraries using phagemids |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
MX9305070A (es) * | 1992-08-21 | 1994-04-29 | Genentech Inc | Compocicion farmaceutica que contiene un antagonista de lfa-1 para el tratamiento de transtornos o desordenes mediados por el lfa-1 |
EP0672131B1 (de) | 1992-10-30 | 2003-12-17 | The General Hospital Corporation | Ein neues zellzyklus kontrollprotein |
EP0621338A3 (de) * | 1993-04-21 | 1997-10-29 | Ajinomoto Kk | Die Interleukin-2 Antwort blockierende Immunsuppressor. |
US20020127201A1 (en) * | 1994-07-01 | 2002-09-12 | Dana-Farber Cancer Institute. | Methods for inhibiting T cell responses by manipulating a common cytokine receptor gamma-chain |
-
1994
- 1994-07-01 US US08/270,152 patent/US6576236B1/en not_active Expired - Fee Related
-
1995
- 1995-06-30 AU AU29152/95A patent/AU2915295A/en not_active Abandoned
- 1995-06-30 ES ES95924766T patent/ES2299174T3/es not_active Expired - Lifetime
- 1995-06-30 CA CA002194239A patent/CA2194239A1/en not_active Abandoned
- 1995-06-30 EP EP08003027A patent/EP1958966A2/de not_active Withdrawn
- 1995-06-30 AT AT95924766T patent/ATE386537T1/de not_active IP Right Cessation
- 1995-06-30 EP EP95924766A patent/EP0768890B1/de not_active Expired - Lifetime
- 1995-06-30 JP JP8503948A patent/JPH10502372A/ja not_active Withdrawn
- 1995-06-30 WO PCT/US1995/008320 patent/WO1996001122A1/en active IP Right Grant
- 1995-06-30 DK DK95924766T patent/DK0768890T3/da active
- 1995-06-30 DE DE69535713T patent/DE69535713T2/de not_active Expired - Fee Related
-
2003
- 2003-06-10 US US10/458,069 patent/US20040037808A1/en not_active Abandoned
-
2007
- 2007-01-25 JP JP2007014706A patent/JP2007112815A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0768890A1 (de) | 1997-04-23 |
ES2299174T3 (es) | 2008-05-16 |
AU2915295A (en) | 1996-01-25 |
DE69535713T2 (de) | 2009-03-19 |
US6576236B1 (en) | 2003-06-10 |
ATE386537T1 (de) | 2008-03-15 |
CA2194239A1 (en) | 1996-01-18 |
DE69535713D1 (de) | 2008-04-03 |
US20040037808A1 (en) | 2004-02-26 |
JPH10502372A (ja) | 1998-03-03 |
WO1996001122A1 (en) | 1996-01-18 |
JP2007112815A (ja) | 2007-05-10 |
EP1958966A2 (de) | 2008-08-20 |
EP0768890B1 (de) | 2008-02-20 |
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