DK0765400T3 - Screening for inhibitorer af chitinase - Google Patents
Screening for inhibitorer af chitinaseInfo
- Publication number
- DK0765400T3 DK0765400T3 DK95922239T DK95922239T DK0765400T3 DK 0765400 T3 DK0765400 T3 DK 0765400T3 DK 95922239 T DK95922239 T DK 95922239T DK 95922239 T DK95922239 T DK 95922239T DK 0765400 T3 DK0765400 T3 DK 0765400T3
- Authority
- DK
- Denmark
- Prior art keywords
- chitinase
- cells
- screening
- inhibitors
- umbelliferyltriacetyl
- Prior art date
Links
- 102000012286 Chitinases Human genes 0.000 title abstract 2
- 108010022172 Chitinases Proteins 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 230000000749 insecticidal effect Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/20—Coumarin derivatives
- C12Q2334/22—4-Methylumbelliferyl, i.e. beta-methylumbelliferone, 4MU
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
- G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
- G01N2333/395—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts from Saccharomyces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
- G01N2400/24—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar beta-D-Glucans, i.e. having beta 1,n (n=3,4,6) linkages between saccharide units, e.g. xanthan
- G01N2400/28—Chitin, chitosan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/259,409 US5561051A (en) | 1994-06-14 | 1994-06-14 | Screen for inhibitors of chitinase |
| PCT/US1995/007207 WO1995034678A1 (en) | 1994-06-14 | 1995-06-07 | Screen for inhibitors of chitinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0765400T3 true DK0765400T3 (da) | 2001-01-02 |
Family
ID=22984827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95922239T DK0765400T3 (da) | 1994-06-14 | 1995-06-07 | Screening for inhibitorer af chitinase |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5561051A (da) |
| EP (1) | EP0765400B1 (da) |
| AT (1) | ATE196320T1 (da) |
| AU (1) | AU2699595A (da) |
| CA (1) | CA2194983A1 (da) |
| DE (1) | DE69518842T2 (da) |
| DK (1) | DK0765400T3 (da) |
| ES (1) | ES2151070T3 (da) |
| GR (1) | GR3035076T3 (da) |
| PT (1) | PT765400E (da) |
| WO (1) | WO1995034678A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6512166B1 (en) | 1991-06-17 | 2003-01-28 | Cornell Research Foundation, Inc. | Combinations of fungal cell wall degrading enzyme and fungal cell membrane affecting compound |
| US6300176B1 (en) | 1994-07-22 | 2001-10-09 | Semiconductor Energy Laboratory Co., Ltd. | Laser processing method |
| CN1225134A (zh) * | 1996-05-14 | 1999-08-04 | 曼尼托巴大学 | 用固相法检测生物活性物质 |
| US20030017570A1 (en) | 1996-06-14 | 2003-01-23 | Patrick W. Gray | Chitinase materials and methods |
| CA2279378C (en) * | 1997-02-04 | 2005-10-11 | Morten Miller | Method of selectively determining a fungal biomass |
| DE19713572A1 (de) * | 1997-04-02 | 1998-10-22 | Hoechst Ag | Verfahren zum Screening von antimykotisch wirkenden Substanzen |
| US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
| US5997846A (en) * | 1997-11-17 | 1999-12-07 | Albert Einstein College Of Medicine Of Yeshiva University | Method for detecting arthropods |
| US6200951B1 (en) | 1998-03-12 | 2001-03-13 | Icos Corporation | Chitinase chitin-binding fragments |
| US6037333A (en) * | 1998-05-07 | 2000-03-14 | Trustees Of Tufts College | Microbe-inhibiting compositions |
| CN115747298B (zh) * | 2022-10-10 | 2023-10-27 | 浙江大学 | 昆虫烟酰胺酶抑制剂及鉴定方法及用于杀虫剂的用途 |
-
1994
- 1994-06-14 US US08/259,409 patent/US5561051A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 WO PCT/US1995/007207 patent/WO1995034678A1/en active IP Right Grant
- 1995-06-07 DK DK95922239T patent/DK0765400T3/da active
- 1995-06-07 AU AU26995/95A patent/AU2699595A/en not_active Abandoned
- 1995-06-07 PT PT95922239T patent/PT765400E/pt unknown
- 1995-06-07 CA CA002194983A patent/CA2194983A1/en not_active Abandoned
- 1995-06-07 ES ES95922239T patent/ES2151070T3/es not_active Expired - Lifetime
- 1995-06-07 DE DE69518842T patent/DE69518842T2/de not_active Expired - Fee Related
- 1995-06-07 AT AT95922239T patent/ATE196320T1/de not_active IP Right Cessation
- 1995-06-07 EP EP95922239A patent/EP0765400B1/en not_active Expired - Lifetime
-
2000
- 2000-12-13 GR GR20000402764T patent/GR3035076T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69518842D1 (de) | 2000-10-19 |
| GR3035076T3 (en) | 2001-03-30 |
| ATE196320T1 (de) | 2000-09-15 |
| EP0765400B1 (en) | 2000-09-13 |
| US5561051A (en) | 1996-10-01 |
| AU2699595A (en) | 1996-01-05 |
| ES2151070T3 (es) | 2000-12-16 |
| WO1995034678A1 (en) | 1995-12-21 |
| PT765400E (pt) | 2001-03-30 |
| CA2194983A1 (en) | 1995-12-21 |
| DE69518842T2 (de) | 2001-04-19 |
| EP0765400A1 (en) | 1997-04-02 |
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