NL7804725A - 4-aminomethyl-1-(3,3,3-triarypropyl)-4arylpiperidinen en derivaten daarvan, alsmede geneesmiddelen met anti- -diarrhee activiteit, die deze verbindingen als actieve component bevatten. - Google Patents

4-aminomethyl-1-(3,3,3-triarypropyl)-4arylpiperidinen en derivaten daarvan, alsmede geneesmiddelen met anti- -diarrhee activiteit, die deze verbindingen als actieve component bevatten.

Info

Publication number
NL7804725A
NL7804725A NL7804725A NL7804725A NL7804725A NL 7804725 A NL7804725 A NL 7804725A NL 7804725 A NL7804725 A NL 7804725A NL 7804725 A NL7804725 A NL 7804725A NL 7804725 A NL7804725 A NL 7804725A
Authority
NL
Netherlands
Prior art keywords
triarypropyl
aminomethyl
medicines
derivatives
active component
Prior art date
Application number
NL7804725A
Other languages
English (en)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NL7804725A publication Critical patent/NL7804725A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL7804725A 1977-05-02 1978-05-02 4-aminomethyl-1-(3,3,3-triarypropyl)-4arylpiperidinen en derivaten daarvan, alsmede geneesmiddelen met anti- -diarrhee activiteit, die deze verbindingen als actieve component bevatten. NL7804725A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/792,616 US4069223A (en) 1977-05-02 1977-05-02 4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof

Publications (1)

Publication Number Publication Date
NL7804725A true NL7804725A (nl) 1978-11-06

Family

ID=25157505

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7804725A NL7804725A (nl) 1977-05-02 1978-05-02 4-aminomethyl-1-(3,3,3-triarypropyl)-4arylpiperidinen en derivaten daarvan, alsmede geneesmiddelen met anti- -diarrhee activiteit, die deze verbindingen als actieve component bevatten.

Country Status (10)

Country Link
US (1) US4069223A (nl)
JP (1) JPS549281A (nl)
AU (1) AU520250B2 (nl)
CA (1) CA1105465A (nl)
DE (1) DE2819210A1 (nl)
FR (1) FR2389605B1 (nl)
GB (1) GB1581923A (nl)
NL (1) NL7804725A (nl)
SE (1) SE7805011L (nl)
ZA (1) ZA782514B (nl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53125944U (nl) * 1977-12-22 1978-10-06
US4173641A (en) * 1978-05-15 1979-11-06 Pfizer Inc. Di-O-n-alkyl glycerol derivatives as immune stimulants
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
WO2002083134A1 (en) * 2001-04-12 2002-10-24 Pharmacopeia, Inc. Aryl and biaryl piperidines used as mch antagonists
SI2368553T1 (sl) 2003-04-08 2015-05-29 Progenics Pharmaceuticals, Inc. Farmacevtske formulacije, vsebujoče metilnatrekson
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP1749528A1 (en) 2005-08-05 2007-02-07 Pharma C S.A. Pharmaceutical combinations containing a mu opioid agonist and an inhibitor of NO production
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP3064503A1 (en) * 2007-03-29 2016-09-07 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
CA2713568C (en) * 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1125112A (en) 1966-01-07 1968-08-28 Science Union & Cie New derivatives of diazabicyclo-decane and process for preparing them
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds

Also Published As

Publication number Publication date
AU3562278A (en) 1979-11-08
US4069223A (en) 1978-01-17
ZA782514B (en) 1979-06-27
FR2389605A1 (nl) 1978-12-01
AU520250B2 (en) 1982-01-21
CA1105465A (en) 1981-07-21
FR2389605B1 (nl) 1981-07-17
SE7805011L (sv) 1978-11-03
JPS549281A (en) 1979-01-24
DE2819210A1 (de) 1979-02-08
GB1581923A (en) 1980-12-31

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Legal Events

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