DK0763055T3 - Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf - Google Patents

Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0763055T3
DK0763055T3 DK95917216T DK95917216T DK0763055T3 DK 0763055 T3 DK0763055 T3 DK 0763055T3 DK 95917216 T DK95917216 T DK 95917216T DK 95917216 T DK95917216 T DK 95917216T DK 0763055 T3 DK0763055 T3 DK 0763055T3
Authority
DK
Denmark
Prior art keywords
elastase
pct
inhibitors
perflouralkyl
preparation
Prior art date
Application number
DK95917216T
Other languages
Danish (da)
English (en)
Inventor
Norton P Peet
Joseph P Burkhart
Michael R Angelastro
Timothy T Curran
William A Metz Jr
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0763055T3 publication Critical patent/DK0763055T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95917216T 1994-06-02 1995-05-01 Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf DK0763055T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25285794A 1994-06-02 1994-06-02
US32752094A 1994-10-20 1994-10-20
PCT/US1995/005363 WO1995033762A1 (en) 1994-06-02 1995-05-01 Perfluoroalkyl ketone inhibitors of elastase and processes for making the same

Publications (1)

Publication Number Publication Date
DK0763055T3 true DK0763055T3 (da) 2000-05-08

Family

ID=26942742

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95917216T DK0763055T3 (da) 1994-06-02 1995-05-01 Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf

Country Status (19)

Country Link
US (1) US6008196A (de)
EP (1) EP0763055B1 (de)
JP (1) JP3721538B2 (de)
KR (1) KR100366328B1 (de)
CN (1) CN1152048C (de)
AT (1) ATE186305T1 (de)
AU (1) AU690986B2 (de)
CA (1) CA2189526C (de)
DE (1) DE69513167T2 (de)
DK (1) DK0763055T3 (de)
ES (1) ES2137509T3 (de)
FI (1) FI964789A (de)
GR (1) GR3032294T3 (de)
HU (1) HU221311B1 (de)
IL (1) IL113941A (de)
NO (1) NO316706B1 (de)
NZ (1) NZ284766A (de)
TW (1) TW376388B (de)
WO (1) WO1995033762A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DK0763055T3 (da) * 1994-06-02 2000-05-08 Merrell Pharma Inc Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
TR199901681T2 (xx) * 1996-12-06 2000-03-21 Cortech, Inc. Serin proteas inhibit�rleri.
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
US6255453B1 (en) 1998-06-03 2001-07-03 Cortech, Inc. Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
AU3731400A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
KR101036058B1 (ko) * 2002-04-25 2011-05-19 더 스크립스 리서치 인스티튜트 폐질환 증상의 치료 및 예방
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT1531791E (pt) * 2002-06-07 2010-12-16 Dyax Corp Prevenção e redução da isquémia
US20070020252A1 (en) * 2003-08-29 2007-01-25 Ladner Robert C Modified protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
AU2006332774A1 (en) * 2005-12-29 2007-07-12 Dyax Corp. Protease inhibition
JP2010536870A (ja) * 2007-08-21 2010-12-02 ジェンザイム・コーポレーション カリクレイン阻害剤を用いた治療
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
PT3459564T (pt) * 2010-01-06 2022-01-31 Takeda Pharmaceuticals Co Proteínas de ligação à calicreína plasmática
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
IL295414A (en) 2014-03-27 2022-10-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema as a result of diabetes
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
WO2021209739A1 (en) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
US4935405A (en) * 1986-10-31 1990-06-19 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
EP0318318A1 (de) * 1987-11-27 1989-05-31 Sensititre Limited Urintestverfahren und Testsatz
US5162307A (en) * 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
EP0371179A1 (de) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Analoge von Peptidase-Substraten
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
IE910713A1 (en) * 1990-03-05 1991-09-11 Cephalon Inc Chymotrypsin-like proteases
KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체
EP0564561A4 (en) * 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
EP0573603B1 (de) * 1991-03-01 2003-06-25 Dyax Corp. Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g
ATE181925T1 (de) * 1991-05-23 1999-07-15 Merrell Pharma Inc Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
CN1078886C (zh) * 1993-10-01 2002-02-06 默里尔药物公司 抑制β－淀粉样蛋白产生的抑制剂
HU221197B1 (en) * 1994-06-02 2002-08-28 Aventis Pharma Inc Elastase inhibitor tripeptides and pharmaceutical compositions comprising thereof
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
DK0763055T3 (da) * 1994-06-02 2000-05-08 Merrell Pharma Inc Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf

Also Published As

Publication number Publication date
HUT75318A (en) 1997-05-28
DE69513167T2 (de) 2000-06-15
NO965098D0 (no) 1996-11-29
CN1149876A (zh) 1997-05-14
EP0763055B1 (de) 1999-11-03
EP0763055A1 (de) 1997-03-19
NZ284766A (en) 1998-06-26
US6008196A (en) 1999-12-28
FI964789A0 (fi) 1996-11-29
IL113941A (en) 2000-02-17
HU9603311D0 (en) 1997-01-28
TW376388B (en) 1999-12-11
JP3721538B2 (ja) 2005-11-30
NO316706B1 (no) 2004-04-13
AU690986B2 (en) 1998-05-07
CA2189526C (en) 2001-02-27
AU2400095A (en) 1996-01-04
ATE186305T1 (de) 1999-11-15
ES2137509T3 (es) 1999-12-16
CN1152048C (zh) 2004-06-02
IL113941A0 (en) 1995-08-31
MX9606031A (es) 1998-05-31
JPH10501529A (ja) 1998-02-10
NO965098L (no) 1997-01-31
CA2189526A1 (en) 1995-12-14
FI964789A (fi) 1996-11-29
DE69513167D1 (de) 1999-12-09
GR3032294T3 (en) 2000-04-27
HU221311B1 (en) 2002-09-28
KR100366328B1 (ko) 2003-03-06
WO1995033762A1 (en) 1995-12-14

Similar Documents

Publication Publication Date Title
DK0763055T3 (da) Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf
IL130931A0 (en) Small molecules useful in the treatment of inflammatory disease
BR9502707A (pt) Composto composição farmacêutica e método para o tratamento de uma afecção
SE9604793D0 (sv) New polymorphs
ATE262895T1 (de) Verwendung von hemmern des maillard-reaktion zur behandlung von krankheiten zufolge amyloidosis
NO976048D0 (no) Farmasöytiske og diett formuleringer for profylakse og behandling av mave- og tarmforstyrrelser
DE69924375D1 (de) Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms
DE69526937D1 (de) Verwendung von methanbisphosphonsäurederivaten zur behandlung von aufgelockerten prothesen
FI972703A0 (fi) Rekombinantti IL-5-antagonisteja, jotka ovat käyttökelpoisia hoidettaessa IL-5:een liittyviä sairauksia
DK0989973T3 (da) Chalconer med antiproliferativ aktivitet
DE69533876D1 (de) Zusammensetzung für die gentherapeutische Behandlung von Koronar-Arterienerkrankungen.
BR9808923A (pt) Composto, e, processo para fazer o mesmo
TR200200278T2 (tr) Kalsilitik bileşimler
DE59900222D1 (de) Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
DK0787135T3 (da) Vandopløslige derivater af epipodophyllotoxin, fremgangsmåde til fremstilling deraf og anvendelse som et lægemiddel til beh
BG102404A (en) The application of flupirtin for the prevention and treatment of diseases related to impairement of the haematopoeic cellular system
ATE205473T1 (de) Neue borneolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DK0707477T3 (da) Anvendelse af Efaxoran og derivater deraf til fremstilling af lægemidler beregnet til behandling af neurodegenerative sygdo
DK0808306T3 (da) Hidtil ukendte pyridin- eller pyridazinderivater, fremgangsmåder til fremstilling deraf og lægemidler indeholdende disse fo
NO974687D0 (no) Kondenserte <beta>-carboliner
ATE312611T1 (de) Verwendung von mizolastine zur herstellung eines arzneimittels zur behandlung von entzündungen