DK0752991T3 - Indeno[1,2-e]pyrazin-4-oner, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser - Google Patents
Indeno[1,2-e]pyrazin-4-oner, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelserInfo
- Publication number
- DK0752991T3 DK0752991T3 DK95914403T DK95914403T DK0752991T3 DK 0752991 T3 DK0752991 T3 DK 0752991T3 DK 95914403 T DK95914403 T DK 95914403T DK 95914403 T DK95914403 T DK 95914403T DK 0752991 T3 DK0752991 T3 DK 0752991T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- pct
- receptor
- indeno
- pyrazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403581A FR2717812B1 (fr) | 1994-03-28 | 1994-03-28 | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
PCT/FR1995/000357 WO1995026349A1 (fr) | 1994-03-28 | 1995-03-23 | INDENO[1,2-e]PYRAZINE-4-ONES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0752991T3 true DK0752991T3 (da) | 1999-11-08 |
Family
ID=9461466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95914403T DK0752991T3 (da) | 1994-03-28 | 1995-03-23 | Indeno[1,2-e]pyrazin-4-oner, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser |
Country Status (13)
Country | Link |
---|---|
US (1) | US5789406A (es) |
EP (1) | EP0752991B1 (es) |
JP (1) | JPH09510726A (es) |
AT (1) | ATE180483T1 (es) |
AU (1) | AU2141295A (es) |
DE (1) | DE69509888T2 (es) |
DK (1) | DK0752991T3 (es) |
ES (1) | ES2134459T3 (es) |
FR (1) | FR2717812B1 (es) |
GR (1) | GR3030273T3 (es) |
IL (1) | IL113147A0 (es) |
WO (1) | WO1995026349A1 (es) |
ZA (1) | ZA952531B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2743366B1 (fr) * | 1996-01-10 | 1998-02-06 | Rhone Poulenc Rorer Sa | Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant |
MXPA03008291A (es) * | 2001-03-14 | 2003-12-11 | Gr Nenthal Gmbh | Pirazolopirimidinas y tiazolopirimidinas sustituidas. |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
SG178953A1 (en) | 2009-09-11 | 2012-04-27 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507300A (en) * | 1980-05-09 | 1985-03-26 | Usv Pharmaceutical Corporation | Pyridotriazolopyrazine-diones for treating allergy |
US4400382A (en) * | 1980-05-09 | 1983-08-23 | Usv Pharmaceutical Corporation | Thiazoloquinoxalin-1,4-diones for treating allergy |
US4668678A (en) * | 1980-05-09 | 1987-05-26 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-1,4-diones |
US4354027A (en) * | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
US5191197A (en) * | 1988-05-11 | 1993-03-02 | Symbol Technologies, Inc. | Arm mounted scanner actuatable by hand movement |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
US5196421A (en) * | 1991-06-05 | 1993-03-23 | Eli Lilly And Company | Excitatory amino acid receptor antagonists in methods for the use thereof |
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
JP3301024B2 (ja) * | 1992-06-22 | 2002-07-15 | ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア | グリシンレセプター拮抗物質及びその用途 |
FR2696466B1 (fr) * | 1992-10-02 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant. |
DK12293D0 (da) * | 1993-02-02 | 1993-02-02 | Novo Nordisk As | Heterocykliske forbindelser og deres fremstilling og anvendelse |
FR2707643B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2707645B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant. |
-
1994
- 1994-03-28 FR FR9403581A patent/FR2717812B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-23 US US08/714,163 patent/US5789406A/en not_active Expired - Fee Related
- 1995-03-23 DK DK95914403T patent/DK0752991T3/da active
- 1995-03-23 AU AU21412/95A patent/AU2141295A/en not_active Abandoned
- 1995-03-23 WO PCT/FR1995/000357 patent/WO1995026349A1/fr active Search and Examination
- 1995-03-23 AT AT95914403T patent/ATE180483T1/de not_active IP Right Cessation
- 1995-03-23 JP JP7524994A patent/JPH09510726A/ja active Pending
- 1995-03-23 EP EP95914403A patent/EP0752991B1/fr not_active Expired - Lifetime
- 1995-03-23 DE DE69509888T patent/DE69509888T2/de not_active Expired - Fee Related
- 1995-03-23 ES ES95914403T patent/ES2134459T3/es not_active Expired - Lifetime
- 1995-03-27 IL IL11314795A patent/IL113147A0/xx unknown
- 1995-03-28 ZA ZA952531A patent/ZA952531B/xx unknown
-
1999
- 1999-05-27 GR GR980402937T patent/GR3030273T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1995026349A1 (fr) | 1995-10-05 |
EP0752991A1 (fr) | 1997-01-15 |
FR2717812B1 (fr) | 1996-05-10 |
ES2134459T3 (es) | 1999-10-01 |
FR2717812A1 (fr) | 1995-09-29 |
US5789406A (en) | 1998-08-04 |
JPH09510726A (ja) | 1997-10-28 |
ATE180483T1 (de) | 1999-06-15 |
AU2141295A (en) | 1995-10-17 |
EP0752991B1 (fr) | 1999-05-26 |
GR3030273T3 (en) | 1999-08-31 |
ZA952531B (en) | 1996-01-11 |
IL113147A0 (en) | 1995-06-29 |
DE69509888T2 (de) | 1999-09-30 |
DE69509888D1 (de) | 1999-07-01 |
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