ES2134459T3 - Indeno(1,2-e)pirazina-4-onas, su preparacion y los medicamentos que les contienen. - Google Patents
Indeno(1,2-e)pirazina-4-onas, su preparacion y los medicamentos que les contienen.Info
- Publication number
- ES2134459T3 ES2134459T3 ES95914403T ES95914403T ES2134459T3 ES 2134459 T3 ES2134459 T3 ES 2134459T3 ES 95914403 T ES95914403 T ES 95914403T ES 95914403 T ES95914403 T ES 95914403T ES 2134459 T3 ES2134459 T3 ES 2134459T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- receptor
- pirazina
- onas
- indeno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPUESTOS DE LA FORMULA (I) CONDE R ES UN ATOMO DE NITROGENO, OXIGENO O AZUFRE SUSTITUIDO O UN RADICAL C=R{SUB,3}, C(R{SUB,4}R{SUB,5} O CH-R{SUB,6}; R{SUB,1} ES UN RADICAL HIDROXI, POLIFLUOROALCOXI, CARBOXI, ALCOXICARBONIL, -NH-CHO O -NH-CON(ALQ)AR DONDE AR ES OPCIONALMENTE SUSTITUIDO, -N(ALQ)-CONR{SUB,8}R{SUB,9}, -N(ALQ-AR)-CO-NR{SUB,8}R{SUB,9}, -NH-CONR{SUB,9}R{SUB,12}, -NH-CS-NR{SUB,8}R{SUB,9}, N-(ALQ)-CSNR{SUB,8}R{SUB,9}, -NH-CO-R{SUB,10}, -NH-CS-R{SUB,20}, -NHC(=NR{SUB,21}-NR{SUB,7}R{SUB,9}, SO{SUB,2}-NR{SUB,7}R{SUB,9}, OPCIONALMENTE 3-SUSTITUIDO 2-OXO-1-IMIDAZOLIDINIL U OPCIONALMENTE 3-SUSTITUIDO 2-OXO-1 PERHIDROPIRIMIDINIL; R{SUB,2} ES UN ATOMO DE HIDROGENO O HALOGENO O UN RADICAL ALQUILO, ALCOXI, AMINO, NHCO-NH-AR, N=CH.N(ALQ)ALQ'', NITRO, CIANO, FENIL, IMIDAZOLIL, ACILAMINO, SO{SUB,3}H, HIDROXI, POLIFLUOROALCOXI, CARBOXI, ALCOXICARBONIL, -NH-CHO, -NH-CO-N(ALQ)AR EN DONDE AR ES OPCIONALMENTE SUSTITUIDO, -N(ALQ)-CO-NR{SUB,8}R{SUB,9}, -NHSO{SUB,2}-NR{SUB,7}R{SUB,9}, -N(ALQ-AR)-CO-NR{SUB,8}R{SUB,9}, NH-CO-NR{SUB,9}R{SUB,12}, -NH-CS-NR{SUB,8}R{SUB,9}, -N(ALQ)-CSNR{SUB,8}R{SUB,9}, -NH-CO-R{SUB,10}, -NH-CS-R{SUB,20}, -NHC(NR{SUB,21})NR{SUB,7}R{SUB,9}, -NH-SO{SUB,2}-NR{SUB,7}R{SUB,9}, N-(ALQ)-SO{SUB,2}-NR{SUB,7}R{SUB,9}, -CO-NR{SUB,7}R{SUB,9}, -NHSO{SUB,2}ALQ, -NR{SUB,9}R{SUB,11}, -S(O){SUB,M}-ALQ-AR, SO{SUB,2}-NR{SUB,7}R{SUB,9}, OPCIONALMENTE 3-SUSTITUIDO 2-OXO-1IMIDAZOLIDINIL U OPCIONALMENTE 3-SUSTITUIDO 2-OXO-1PERHIDROPIRIMIDINIL; R{SUB,3} ES UN ATOMO DE OXIGENO O UN RADICAL NOH, NO-ALQ-COOX O CH-R{SUB,13}, R{SUB,4} ES UN RADICAL ALQUIL, -ALQ-HET O ALQ-AR; R{SUB,5} ES UN RADICAL ALQUILO C{SUB,1-11} RECTO O RAMIFICADO, ALQ-HET O ALQ-AR, O R{SUB,4} Y R{SUB,5} TOMADOS JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN RADICAL CICLOALQUILO; R{SUB,6} ES UN RADICAL DE UN ATOMO DE HIDROGENO O UN RADICAL HIDROXI, O ALQUIL RECTO O RAMIFICADO C{SUB,1}-{SUB,11}, -NR{SUB,14}R{SUB,15}, -ALQ-HO, ALQNR{SUB,14}R{SUB,15}, ALQ-AR O -ALQ-HET; O SALES DE LOS MISMOS. LOS COMPUESTOS DE LA FORMULA (I) SON ANTAGONISTAS DEL RECEPTOR N-METIL-ASPARTATO- (NMDA) NO COMPETITIVOS, EN CONCRETO LIGANDOS DEL LUGAR DE MODULACION DE LA GLICINA RECEPTORA NMDA, Y SON ANTAGONISTAS DEL RECEPTOR DEL ACIDO ALFA-AMINO-3-HIDROXI-5-METIL4-ISOXAZOLAPROPIONICO, SIENDO TAMBIEN CONOCIDO DICHO RECEPTOR COMO RECEPTOR QUISCUALATO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403581A FR2717812B1 (fr) | 1994-03-28 | 1994-03-28 | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134459T3 true ES2134459T3 (es) | 1999-10-01 |
Family
ID=9461466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95914403T Expired - Lifetime ES2134459T3 (es) | 1994-03-28 | 1995-03-23 | Indeno(1,2-e)pirazina-4-onas, su preparacion y los medicamentos que les contienen. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5789406A (es) |
EP (1) | EP0752991B1 (es) |
JP (1) | JPH09510726A (es) |
AT (1) | ATE180483T1 (es) |
AU (1) | AU2141295A (es) |
DE (1) | DE69509888T2 (es) |
DK (1) | DK0752991T3 (es) |
ES (1) | ES2134459T3 (es) |
FR (1) | FR2717812B1 (es) |
GR (1) | GR3030273T3 (es) |
IL (1) | IL113147A0 (es) |
WO (1) | WO1995026349A1 (es) |
ZA (1) | ZA952531B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2743366B1 (fr) * | 1996-01-10 | 1998-02-06 | Rhone Poulenc Rorer Sa | Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant |
KR20030082982A (ko) * | 2001-03-14 | 2003-10-23 | 그뤼넨탈 게엠베하 | 치환된 피라졸로피리미딘 및 티아졸로피리미딘 |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
EP2475428B1 (en) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4400382A (en) * | 1980-05-09 | 1983-08-23 | Usv Pharmaceutical Corporation | Thiazoloquinoxalin-1,4-diones for treating allergy |
US4668678A (en) * | 1980-05-09 | 1987-05-26 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-1,4-diones |
US4507300A (en) * | 1980-05-09 | 1985-03-26 | Usv Pharmaceutical Corporation | Pyridotriazolopyrazine-diones for treating allergy |
US4354027A (en) * | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
US5191197A (en) * | 1988-05-11 | 1993-03-02 | Symbol Technologies, Inc. | Arm mounted scanner actuatable by hand movement |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
US5196421A (en) * | 1991-06-05 | 1993-03-23 | Eli Lilly And Company | Excitatory amino acid receptor antagonists in methods for the use thereof |
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
KR100304017B1 (ko) * | 1992-06-22 | 2001-11-22 | 추후제출 | 글리신수용체길항물질및이의용도 |
FR2696466B1 (fr) * | 1992-10-02 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant. |
DK12293D0 (da) * | 1993-02-02 | 1993-02-02 | Novo Nordisk As | Heterocykliske forbindelser og deres fremstilling og anvendelse |
FR2707643B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2707645B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant. |
-
1994
- 1994-03-28 FR FR9403581A patent/FR2717812B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-23 DE DE69509888T patent/DE69509888T2/de not_active Expired - Fee Related
- 1995-03-23 EP EP95914403A patent/EP0752991B1/fr not_active Expired - Lifetime
- 1995-03-23 AT AT95914403T patent/ATE180483T1/de not_active IP Right Cessation
- 1995-03-23 ES ES95914403T patent/ES2134459T3/es not_active Expired - Lifetime
- 1995-03-23 AU AU21412/95A patent/AU2141295A/en not_active Abandoned
- 1995-03-23 US US08/714,163 patent/US5789406A/en not_active Expired - Fee Related
- 1995-03-23 JP JP7524994A patent/JPH09510726A/ja active Pending
- 1995-03-23 DK DK95914403T patent/DK0752991T3/da active
- 1995-03-23 WO PCT/FR1995/000357 patent/WO1995026349A1/fr active Search and Examination
- 1995-03-27 IL IL11314795A patent/IL113147A0/xx unknown
- 1995-03-28 ZA ZA952531A patent/ZA952531B/xx unknown
-
1999
- 1999-05-27 GR GR980402937T patent/GR3030273T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA952531B (en) | 1996-01-11 |
DE69509888T2 (de) | 1999-09-30 |
EP0752991B1 (fr) | 1999-05-26 |
FR2717812A1 (fr) | 1995-09-29 |
AU2141295A (en) | 1995-10-17 |
DK0752991T3 (da) | 1999-11-08 |
FR2717812B1 (fr) | 1996-05-10 |
US5789406A (en) | 1998-08-04 |
IL113147A0 (en) | 1995-06-29 |
WO1995026349A1 (fr) | 1995-10-05 |
ATE180483T1 (de) | 1999-06-15 |
JPH09510726A (ja) | 1997-10-28 |
EP0752991A1 (fr) | 1997-01-15 |
GR3030273T3 (en) | 1999-08-31 |
DE69509888D1 (de) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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