DK0751957T3 - Peptid-fragmenter af mikrobielle stressproteiner og farmaceutisk sammensætning fremstillet deraf til behandling og forebyggelse af inflammatoriske sygdomme - Google Patents
Peptid-fragmenter af mikrobielle stressproteiner og farmaceutisk sammensætning fremstillet deraf til behandling og forebyggelse af inflammatoriske sygdommeInfo
- Publication number
- DK0751957T3 DK0751957T3 DK95912506T DK95912506T DK0751957T3 DK 0751957 T3 DK0751957 T3 DK 0751957T3 DK 95912506 T DK95912506 T DK 95912506T DK 95912506 T DK95912506 T DK 95912506T DK 0751957 T3 DK0751957 T3 DK 0751957T3
- Authority
- DK
- Denmark
- Prior art keywords
- aminoacids
- microbial
- treatment
- peptides
- mammalian
- Prior art date
Links
- 102000002812 Heat-Shock Proteins Human genes 0.000 title abstract 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 title abstract 4
- 230000000813 microbial effect Effects 0.000 title abstract 4
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 title 1
- 102000007079 Peptide Fragments Human genes 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94200721 | 1994-03-21 | ||
EP94200738 | 1994-03-22 | ||
EP94202927 | 1994-10-10 | ||
PCT/NL1995/000108 WO1995025744A1 (en) | 1994-03-21 | 1995-03-21 | Peptide fragments of microbial stress proteins and pharmaceutical composition made thereof for the treatment and prevention of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0751957T3 true DK0751957T3 (da) | 2004-06-01 |
Family
ID=27235971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95912506T DK0751957T3 (da) | 1994-03-21 | 1995-03-21 | Peptid-fragmenter af mikrobielle stressproteiner og farmaceutisk sammensætning fremstillet deraf til behandling og forebyggelse af inflammatoriske sygdomme |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0751957B1 (de) |
JP (2) | JPH09511239A (de) |
AT (1) | ATE260295T1 (de) |
AU (1) | AU699007B2 (de) |
CA (1) | CA2185826C (de) |
DE (1) | DE69532605T2 (de) |
DK (1) | DK0751957T3 (de) |
ES (1) | ES2216009T3 (de) |
PT (1) | PT751957E (de) |
WO (1) | WO1995025744A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9419553D0 (en) * | 1994-09-27 | 1994-11-16 | Univ Bristol | Polypeptides and their use in the treatment of auto-immune disease |
GB9519737D0 (en) * | 1995-09-27 | 1995-11-29 | Peptide Therapeutics Ltd | Polypeptides and their use in treatment and prophylaxis of auto-immune |
US5985287A (en) * | 1996-08-29 | 1999-11-16 | Genesis Research And Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
US6284255B1 (en) * | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
US5968524A (en) * | 1997-12-23 | 1999-10-19 | Genesis Research & Development Corp. | Methods and compounds for the treatment of immunologically-mediated psoriasis |
EP0947524A1 (de) * | 1998-03-30 | 1999-10-06 | Upither B.V. | Neue Peptide zur Behandlung von Autoimmunkrankheiten |
IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
ES2257082T3 (es) | 1998-11-05 | 2006-07-16 | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT CO. LTD. | Nuevas secuencias de aminoacidos, adn que codifica las secuencias de aminoacidos, anticuerpos dirigidos contra tales secuencias y los diferentes usos de ello. |
US7488476B2 (en) | 1998-11-05 | 2009-02-10 | Hadasit Medical Research Services & Development Ltd. | B-cell epitope peptides of HSP 65, DNA encoding said peptides, antibodies directed against said peptides and the different uses thereof in the treatment of inflammatory and autoimmune diseases |
US8158125B2 (en) | 1998-11-05 | 2012-04-17 | Hadasit Medical Research Services & Development Ltd. | B-cell epitope peptides of HSP 65, novel amino acid sequences, DNA encoding the amino acid sequences of said peptides, antibodies directed against said peptides and different uses thereof in the treatment of inflammatory and autoimmune diseases |
US6638518B1 (en) * | 1999-02-22 | 2003-10-28 | University Of Iowa Research Foundation | Method for inhibiting inflammatory responses |
IL132611A0 (en) | 1999-10-27 | 2001-03-19 | Yeda Res & Dev | Synthetic genes and polypeptides and pharmaceutical compositions comprising them |
US6812205B2 (en) | 2000-03-15 | 2004-11-02 | The Brigham & Women's Hospital, Inc. | Suppression of vascular disorders by mucosal administration of heat shock protein peptides |
US6989146B2 (en) * | 2000-08-09 | 2006-01-24 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
US7608683B2 (en) | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
EP1652856A1 (de) * | 2000-08-09 | 2006-05-03 | The Regents of The University of California San Diego | Stressproteine-abgeleitete Peptide und Verfahren zu deren Verwendung |
GB0028122D0 (en) * | 2000-11-17 | 2001-01-03 | St Georges Entpr Ltd | Method |
EP1575479A4 (de) | 2002-01-31 | 2006-10-25 | Develogen Israel Ltd | Hsp-peptide und analoga zur modulation von immunantworten über antigen präsentierende zellen |
WO2006072946A2 (en) | 2005-01-04 | 2006-07-13 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Hsp60, hsp60 peptides and t cell vaccines for immunomodulation |
CN101801402B (zh) | 2007-07-06 | 2013-08-28 | 乌得勒支大学控股有限公司 | 炎性疾病和自身免疫疾病的治疗和预防 |
BR122019024895B8 (pt) | 2008-06-26 | 2021-07-27 | Orphazyme As | uso de um agente bioativo capaz de aumentar a concentração intracelular de hsp70 |
JP5350996B2 (ja) * | 2009-11-25 | 2013-11-27 | バブコック日立株式会社 | 酸素燃焼システムの排ガス処理装置 |
CN103338784A (zh) | 2010-11-30 | 2013-10-02 | 奥菲泽米有限公司 | 用于增加Hsp70细胞内活性的方法 |
PL3193840T3 (pl) | 2014-09-15 | 2021-12-06 | Orphazyme A/S | Preparat arimoklomolu |
US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
CN109069496A (zh) | 2016-04-29 | 2018-12-21 | 奥菲泽米有限公司 | 用于治疗葡糖脑苷脂酶相关疾病的arimoclomol |
NZ800483A (en) | 2020-11-19 | 2024-03-22 | Zevra Denmark As | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8701163A (nl) * | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
US4952395A (en) * | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
NL8703107A (nl) * | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
CA2071896A1 (en) * | 1990-09-06 | 1992-03-07 | Willem Van Eden | Inhibitor of lymphocyte response and immune-related disease |
-
1995
- 1995-03-21 DK DK95912506T patent/DK0751957T3/da active
- 1995-03-21 AT AT95912506T patent/ATE260295T1/de not_active IP Right Cessation
- 1995-03-21 AU AU19628/95A patent/AU699007B2/en not_active Ceased
- 1995-03-21 CA CA002185826A patent/CA2185826C/en not_active Expired - Fee Related
- 1995-03-21 DE DE69532605T patent/DE69532605T2/de not_active Expired - Fee Related
- 1995-03-21 ES ES95912506T patent/ES2216009T3/es not_active Expired - Lifetime
- 1995-03-21 PT PT95912506T patent/PT751957E/pt unknown
- 1995-03-21 JP JP7524557A patent/JPH09511239A/ja active Pending
- 1995-03-21 WO PCT/NL1995/000108 patent/WO1995025744A1/en active IP Right Grant
- 1995-03-21 EP EP95912506A patent/EP0751957B1/de not_active Expired - Lifetime
-
2006
- 2006-08-09 JP JP2006217557A patent/JP2007000147A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69532605D1 (de) | 2004-04-01 |
CA2185826C (en) | 2007-06-19 |
DE69532605T2 (de) | 2005-02-17 |
CA2185826A1 (en) | 1995-09-28 |
PT751957E (pt) | 2004-07-30 |
AU699007B2 (en) | 1998-11-19 |
WO1995025744A1 (en) | 1995-09-28 |
JP2007000147A (ja) | 2007-01-11 |
EP0751957A1 (de) | 1997-01-08 |
EP0751957B1 (de) | 2004-02-25 |
ES2216009T3 (es) | 2004-10-16 |
AU1962895A (en) | 1995-10-09 |
JPH09511239A (ja) | 1997-11-11 |
ATE260295T1 (de) | 2004-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0751957T3 (da) | Peptid-fragmenter af mikrobielle stressproteiner og farmaceutisk sammensætning fremstillet deraf til behandling og forebyggelse af inflammatoriske sygdomme | |
Atoda et al. | The primary structure of coagulation factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis. Homology with asialoglycoprotein receptors, proteoglycan core protein, tetranectin, and lymphocyte Fc epsilon receptor for immunoglobulin E | |
Hirabayashi et al. | Complete primary structure of a galactose-specific lectin from the venom of the rattlesnake Crotalus atrox. Homologies with Ca2 (+)-dependent-type lectins | |
PT672145E (pt) | Polipeptideos de interleucina-3(il-3) com multiplas mutacoes | |
EA199800973A1 (ru) | Полипептид белка-106 наружной мембраны moraxella catarrhalis, последовательность гена и их применение | |
ATE352559T1 (de) | Verfahren zur verminderung der immunogenität von proteinen | |
ATE336511T1 (de) | Peptide und peptidomimetika mit struktureller ähnlichkeit mit p53 und die die p53-funktion aktivieren | |
DE68916932D1 (de) | Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus. | |
PT93910A (pt) | Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula | |
DE10075019I2 (de) | Neue Proteine mit TNF-Hemmender Wirkung und ihre Herstellung. | |
BR9914066A (pt) | Polipeptìdio degradador de c3 de complemento humano de streptococcus pneumoniae | |
Alsenz et al. | Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species | |
HUP9901688A2 (hu) | A diabétesz kezelésére szolgáló, humán hősokk protein 60-ból származó új peptidek, készítmények, eljárások és kitek | |
HUT69169A (en) | T-cell-suppressive peptide fragments of human myelin basic protein (hmbp) and pharmaceutical compositions containing them | |
DK0687180T3 (da) | Fremgangsmåde til påvisning og behandling af individer, som har unormale celler, som udtrykker HLC-A2/tyrosinasepeptid-anti | |
ATE282634T1 (de) | Chaperonin 10 | |
Southan et al. | Amino acid sequence of β‐galactoside‐binding bovine heart lectin: Member of a novel class of vertebrate proteins | |
CA2351558A1 (en) | Peptide fragments having cell death inhibitory activity | |
ATE357526T1 (de) | Modifizierte hcv peptid-impfstoffe | |
DK0667781T3 (da) | Peptidbaserede diagnostiske og terapeutiske midler til spondylarthropatier | |
ATE183652T1 (de) | Synthetische peptide für die behandlung von myasthenia gravis | |
Fairwell et al. | Acetylated N‐terminal structures of class III alcohol dehydrogenases Differences among the three enzyme classes | |
NO960748L (no) | Rekombinante Alternaria alternata allergener | |
Debuire et al. | Structural studies of human IgD |