DK0745080T3 - Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE. - Google Patents

Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE.

Info

Publication number
DK0745080T3
DK0745080T3 DK95907206T DK95907206T DK0745080T3 DK 0745080 T3 DK0745080 T3 DK 0745080T3 DK 95907206 T DK95907206 T DK 95907206T DK 95907206 T DK95907206 T DK 95907206T DK 0745080 T3 DK0745080 T3 DK 0745080T3
Authority
DK
Denmark
Prior art keywords
enkephalinase
ace
inhibitors
pct
disulfide derivatives
Prior art date
Application number
DK95907206T
Other languages
Danish (da)
English (en)
Inventor
Gary A Flynn
John H Kehne
Alan M Warshawsky
Douglas W Beight
Shujaath Mehdi
John F French
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0745080T3 publication Critical patent/DK0745080T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DK95907206T 1994-02-14 1994-12-13 Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE. DK0745080T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19542394A 1994-02-14 1994-02-14
PCT/US1994/014235 WO1995021839A1 (fr) 1994-02-14 1994-12-13 Nouveaux derives bisulfure de mercaptoacetylamides utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine (ace)

Publications (1)

Publication Number Publication Date
DK0745080T3 true DK0745080T3 (da) 1999-09-27

Family

ID=22721368

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95907206T DK0745080T3 (da) 1994-02-14 1994-12-13 Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE.

Country Status (20)

Country Link
US (1) US5750521A (fr)
EP (1) EP0745080B1 (fr)
JP (1) JP3596778B2 (fr)
KR (1) KR100357354B1 (fr)
CN (1) CN1046512C (fr)
AT (1) ATE177098T1 (fr)
AU (1) AU687507B2 (fr)
CA (1) CA2183320C (fr)
DE (1) DE69416873T2 (fr)
DK (1) DK0745080T3 (fr)
ES (1) ES2131806T3 (fr)
FI (1) FI963166A0 (fr)
GR (1) GR3029660T3 (fr)
HU (1) HUT74461A (fr)
IL (1) IL112605A (fr)
NO (1) NO307754B1 (fr)
NZ (1) NZ279012A (fr)
TW (1) TW381094B (fr)
WO (1) WO1995021839A1 (fr)
ZA (1) ZA95934B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
WO2000040564A1 (fr) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. Benzolactames a substitution n-carboxymethyle inhibiteurs de la metalloproteinase matricielle
ATE233259T1 (de) * 1998-12-31 2003-03-15 Aventis Pharma Inc 3-(thio-substituierte amido)-lactame, verwendbar als inhibitoren der matrix-metalloproteinase
GB0119305D0 (en) * 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (fr) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de la pyrazolopyridazine, intermédiaires et leur procédés de préparation, et médicaments les contenant
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
EP0202046B1 (fr) * 1985-04-30 1991-01-30 Eli Lilly And Company Pyrazolidinones bicycliques substituées en position 7
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
CA1337654C (fr) * 1986-06-13 1995-11-28 Gary A. Flynn Lactames tricycliques fondus servant d'agents antihypertenseurs
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (fr) * 1990-10-18 2002-04-02 Timothy P. Burkholder Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace
ATE158303T1 (de) * 1990-12-21 1997-10-15 Merrell Pharma Inc Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
WO1993005809A1 (fr) * 1991-09-16 1993-04-01 Schering Corporation Compositions pharmaceutiques comprenant des peptides natriuretiques ou des inhibiteurs d'endopeptidase neutres utilises dans le traitement ou la prevention de la proliferation dans la myointima
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam

Also Published As

Publication number Publication date
ZA95934B (en) 1995-10-09
GR3029660T3 (en) 1999-06-30
CA2183320C (fr) 1999-10-26
IL112605A (en) 2002-11-10
NO307754B1 (no) 2000-05-22
ATE177098T1 (de) 1999-03-15
AU687507B2 (en) 1998-02-26
KR970701188A (ko) 1997-03-17
FI963166A (fi) 1996-08-13
FI963166A0 (fi) 1996-08-13
CN1046512C (zh) 1999-11-17
NZ279012A (en) 1998-03-25
TW381094B (en) 2000-02-01
KR100357354B1 (ko) 2003-01-30
EP0745080A1 (fr) 1996-12-04
DE69416873T2 (de) 1999-07-29
DE69416873D1 (en) 1999-04-08
CN1142826A (zh) 1997-02-12
US5750521A (en) 1998-05-12
AU1551295A (en) 1995-08-29
HUT74461A (en) 1996-12-30
IL112605A0 (en) 1995-05-26
JP3596778B2 (ja) 2004-12-02
NO963367L (no) 1996-10-14
JPH09509158A (ja) 1997-09-16
HU9602228D0 (en) 1996-10-28
ES2131806T3 (es) 1999-08-01
EP0745080B1 (fr) 1999-03-03
WO1995021839A1 (fr) 1995-08-17
CA2183320A1 (fr) 1995-08-17
NO963367D0 (no) 1996-08-13

Similar Documents

Publication Publication Date Title
NO963370D0 (no) Nye mercaptoacetylamido-1,3,4,5-tetrahydro-benzo[cÅazepin-3-on-disulfidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
NO914092L (no) Nye mercaptoacetylamid-derivater som er anvendbare som inhibitorer for enkefalinase og ace
NO943165D0 (no) Heterocykliske karbonsyrederivater som binder til retinoid-reseptorer (RAR)
DK0696281T3 (da) Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater
ATE206402T1 (de) 3-acylaminobenzazepine
DK0667856T3 (da) Nye D-vitaminanaloger
FI943931A (fi) Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
NO962285D0 (no) N-substituerte azabicykloheptan-derivater anvendt for eksempel som neuroleptika
DK0745080T3 (da) Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE.
DE69426462D1 (de) Phenylindolverbindungen
NO963369D0 (no) Nye indan-2-mercaptoacetylamid-disulfidderivater som er anvendbare som inhibitorer av enkefalinase
ATE163402T1 (de) Substituierte ortho- ethenylphenylessigsäurederivate
FI962322A (fi) (S,S,S)-N-(1-(2-karboksi-3-(N2-mesyylilysyyliamino)propyyli)1-syklopentyylikarbonyylityrosiinin kiteinen polymorfinen muoto
DE69105489D1 (de) S-(2-thenoyl)-thiolactonsäure mit pharmazeutischer wirkung.
BR9507668A (pt) Intermédio para preparar um composto farmaceuticamente atívo