DK0728140T3 - Hidtil ukendte steroider med radikofile substituenter, fremgangsmåde til deres fremstilling og lægemidler indholdende disse forbindelser - Google Patents

Hidtil ukendte steroider med radikofile substituenter, fremgangsmåde til deres fremstilling og lægemidler indholdende disse forbindelser

Info

Publication number
DK0728140T3
DK0728140T3 DK95900069T DK95900069T DK0728140T3 DK 0728140 T3 DK0728140 T3 DK 0728140T3 DK 95900069 T DK95900069 T DK 95900069T DK 95900069 T DK95900069 T DK 95900069T DK 0728140 T3 DK0728140 T3 DK 0728140T3
Authority
DK
Denmark
Prior art keywords
substituents
methods
radical
compounds
novel substituted
Prior art date
Application number
DK95900069T
Other languages
Danish (da)
English (en)
Inventor
Michael Oettel
Peter Droescher
Bernd Menzenbach
Jens Schroeder
Kurt Ponsold
Guenter Kaufmann
Bernd Undeutsch
Wolfgang Roemer
Original Assignee
Jenapharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh filed Critical Jenapharm Gmbh
Application granted granted Critical
Publication of DK0728140T3 publication Critical patent/DK0728140T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
DK95900069T 1993-11-10 1994-11-08 Hidtil ukendte steroider med radikofile substituenter, fremgangsmåde til deres fremstilling og lægemidler indholdende disse forbindelser DK0728140T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4338316A DE4338316A1 (de) 1993-11-10 1993-11-10 Neue Steroide mit radikophilen Substituenten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/DE1994/001310 WO1995013287A1 (de) 1993-11-10 1994-11-08 Neue steroide mit radikophilen substituenten, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DK0728140T3 true DK0728140T3 (da) 2001-12-10

Family

ID=6502215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95900069T DK0728140T3 (da) 1993-11-10 1994-11-08 Hidtil ukendte steroider med radikofile substituenter, fremgangsmåde til deres fremstilling og lægemidler indholdende disse forbindelser

Country Status (11)

Country Link
US (2) US5914325A (es)
EP (1) EP0728140B1 (es)
JP (1) JP2828780B2 (es)
AT (1) ATE205851T1 (es)
AU (1) AU8104294A (es)
CA (1) CA2176368A1 (es)
DE (2) DE4338316A1 (es)
DK (1) DK0728140T3 (es)
ES (1) ES2162906T3 (es)
PT (1) PT728140E (es)
WO (1) WO1995013287A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319914B1 (en) 1993-11-05 2001-11-20 Apollo Biopharmaceuticals, Inc. Cytoprotective effect of polycyclic phenolic compounds
US6327387B1 (en) 1996-12-27 2001-12-04 Fujitsu Limited Apparatus and method for extracting management information from image
DE19723794A1 (de) 1997-06-06 1998-12-10 Jenapharm Gmbh Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
US6355630B1 (en) 1997-10-23 2002-03-12 American Home Products Corporation Estra-1,3,5(10)-triene-7α-thioethers
JP2001520235A (ja) * 1997-10-23 2001-10-30 アメリカン・ホーム・プロダクツ・コーポレイション エストラ−１，３，５（１０）−トリエン−７α−チオエーテル
ATE361310T1 (de) * 2000-11-03 2007-05-15 Univ Washington Östronderivate mit zellschützender wirkung
AU2002228891A1 (en) * 2000-11-17 2002-05-27 Washington University Cytoprotective estrogen derivatives
CA2457142A1 (en) * 2001-08-17 2003-02-27 University Of Pittsburgh Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
US9284345B2 (en) * 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
RS58166B1 (sr) 2013-03-13 2019-03-29 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA45598B1 (fr) 2016-07-07 2021-09-30 Sage Therapeutics Inc Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda
AU2017337121B2 (en) 2016-09-30 2022-01-27 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as NMDA modulators
EP4105223A1 (en) 2016-10-18 2022-12-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3193564A (en) * 1964-01-27 1965-07-06 Searle & Co 17alpha-(aralkyl)estra-1, 3, 5(10)-triene-3, 17beta-diols, intermediates thereto, and esters corresponding
GB1076962A (en) * 1965-02-25 1967-07-26 British Drug Houses Ltd Steroidal 6-substituted-methyl-4,6-dien-3-ones
DE2247390A1 (de) * 1972-09-27 1974-03-28 Merck Patent Gmbh Neue 1-alkylthio-androstan-derivate
FR2407940A1 (fr) * 1977-11-08 1979-06-01 Roussel Uclaf Nouveaux derives steroides 17 a-aryle, ou 17 a-heteroaryle, leur procede de preparation et leur application comme medicament
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
US5371078A (en) * 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
FR2644789B1 (fr) * 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2644788B1 (fr) * 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 3-ceto comportant une chaine en 17 amino-substituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2644787B1 (fr) * 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 21 aminosubstitues, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
AU642711B2 (en) * 1990-01-26 1993-10-28 Upjohn Company, The 5-oxygenated-2,4,6-triaminopyrimidines
DE4312034A1 (de) * 1993-04-13 1994-10-20 Hesch Rolf Dieter Prof Dr Med Neuartige Androgene und Anabolika

Also Published As

Publication number Publication date
EP0728140A1 (de) 1996-08-28
ATE205851T1 (de) 2001-10-15
JPH09507471A (ja) 1997-07-29
PT728140E (pt) 2002-02-28
US5914325A (en) 1999-06-22
US5977096A (en) 1999-11-02
DE4338316A1 (de) 1995-05-11
JP2828780B2 (ja) 1998-11-25
AU8104294A (en) 1995-05-29
EP0728140B1 (de) 2001-09-19
DE59409872D1 (de) 2001-10-25
ES2162906T3 (es) 2002-01-16
CA2176368A1 (en) 1995-05-18
WO1995013287A1 (de) 1995-05-18

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