DK0721500T3 - Insulinsecernerende cellelinjer og fremgangsmåder til opnåelse og anvendelse deraf - Google Patents

Insulinsecernerende cellelinjer og fremgangsmåder til opnåelse og anvendelse deraf

Info

Publication number
DK0721500T3
DK0721500T3 DK94928920T DK94928920T DK0721500T3 DK 0721500 T3 DK0721500 T3 DK 0721500T3 DK 94928920 T DK94928920 T DK 94928920T DK 94928920 T DK94928920 T DK 94928920T DK 0721500 T3 DK0721500 T3 DK 0721500T3
Authority
DK
Denmark
Prior art keywords
pct
cell line
sec
beta
obtaining
Prior art date
Application number
DK94928920T
Other languages
Danish (da)
English (en)
Inventor
Maryam Asfari
Paul Czernichow
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0721500T3 publication Critical patent/DK0721500T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0677Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK94928920T 1993-09-30 1994-09-27 Insulinsecernerende cellelinjer og fremgangsmåder til opnåelse og anvendelse deraf DK0721500T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311687A FR2710654B1 (fr) 1993-09-30 1993-09-30 Nouvelles lignées de cellules sécrétrices d'insuline, leurs procédés d'obtention par voie de manipulation génétique et leur utilisation chez des sujets diabétiques sous forme protégée.
EP94928920A EP0721500B1 (fr) 1993-09-30 1994-09-27 Lignees de cellules secretrices d'insuline, procedes d'obtention et utilisation

Publications (1)

Publication Number Publication Date
DK0721500T3 true DK0721500T3 (da) 2005-10-17

Family

ID=9451437

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928920T DK0721500T3 (da) 1993-09-30 1994-09-27 Insulinsecernerende cellelinjer og fremgangsmåder til opnåelse og anvendelse deraf

Country Status (17)

Country Link
US (1) US5902577A (sv)
EP (1) EP0721500B1 (sv)
JP (2) JPH09503662A (sv)
KR (2) KR100432851B1 (sv)
CN (1) CN1078248C (sv)
AT (1) ATE299930T1 (sv)
AU (1) AU688383B2 (sv)
BR (1) BR9407682A (sv)
CA (1) CA2172997A1 (sv)
DE (1) DE69434433T2 (sv)
DK (1) DK0721500T3 (sv)
ES (1) ES2243929T3 (sv)
FI (1) FI961440A0 (sv)
FR (1) FR2710654B1 (sv)
HU (1) HU219826B (sv)
NO (1) NO317236B1 (sv)
WO (1) WO1995009231A1 (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427940A (en) * 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
US5744327A (en) * 1990-02-20 1998-04-28 Board Of Regents, The University Of Texas System Methods for producing insulin in response to non-glucose secretagogues
US5792656A (en) * 1991-06-03 1998-08-11 Board Of Regents, The University Of Texas System Methods of preparing genetically engineered cells that produce insulin in response to glucose
US6642003B2 (en) 2001-08-02 2003-11-04 Cedars-Sinai Medical Center Human glucose-dependent insulin-secreting cell line
GB2415432B (en) * 2001-12-07 2006-09-06 Geron Corp Islet cells from human embryonic stem cells
US7141240B2 (en) * 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN109957539A (zh) * 2017-12-14 2019-07-02 深圳先进技术研究院 一种人造胰岛组织及其制备和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229526B4 (de) * 1992-09-07 2006-02-16 Schrezenmeir, Jürgen, Dr. Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper

Also Published As

Publication number Publication date
FI961440A (sv) 1996-03-29
KR960705028A (ko) 1996-10-09
CN1078248C (zh) 2002-01-23
DE69434433D1 (de) 2005-08-25
EP0721500B1 (fr) 2005-07-20
AU7815794A (en) 1995-04-18
AU688383B2 (en) 1998-03-12
FI961440A0 (sv) 1996-03-29
FR2710654A1 (fr) 1995-04-07
HUT75985A (en) 1997-05-28
FR2710654B1 (fr) 1995-12-22
WO1995009231A1 (fr) 1995-04-06
NO961268D0 (no) 1996-03-29
KR20040017357A (ko) 2004-02-26
KR100432851B1 (ko) 2004-11-06
BR9407682A (pt) 1997-02-04
CA2172997A1 (en) 1995-04-06
NO961268L (no) 1996-03-29
US5902577A (en) 1999-05-11
EP0721500A1 (fr) 1996-07-17
CN1134724A (zh) 1996-10-30
DE69434433T2 (de) 2006-04-20
NO317236B1 (no) 2004-09-27
HU219826B (hu) 2001-08-28
ES2243929T3 (es) 2005-12-01
KR100463366B1 (ko) 2004-12-29
HU9600789D0 (en) 1996-05-28
JP2005185293A (ja) 2005-07-14
ATE299930T1 (de) 2005-08-15
JPH09503662A (ja) 1997-04-15

Similar Documents

Publication Publication Date Title
WO2004016747A3 (en) Bone marrow cell differentiation
Bearzi et al. PlGF–MMP9-engineered iPS cells supported on a PEG–fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium
Gorlatov et al. Human thioredoxin reductase from HeLa cells: selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin
AU2369595A (en) In vitro growth of functional islets of langerhans and in vivo uses thereof
ATE270323T1 (de) Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo
DE69634828D1 (de) Auffindbare künstliche bioimplantate
WO2003072728A3 (en) Cellular trans-differentiation
DK0721500T3 (da) Insulinsecernerende cellelinjer og fremgangsmåder til opnåelse og anvendelse deraf
Berg et al. Ex-vivo expansion of NK cells: What is the priority-high yield or high purity?
Triolo et al. Lessons from human islet transplantation inform stem cell-based approaches in the treatment of diabetes
Kin et al. The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment
Matsumoto et al. Insulin independence of unstable diabetic patient after single living donor islet transplantation
Noguchi Regulation of c-Jun NH2-terminal kinase for islet transplantation
CA2488414A1 (en) Primary cultured adipocytes for gene therapy
RU2008145053A (ru) Клеточная терапия: композиция и способ для лечения диабета
Maestas et al. Recent progress in modeling and treating diabetes using stem cell-derived islets
ATE341630T1 (de) Verwendung von pankreatischer procarboxypeptidase b zur herstellung von insulin
Oberholzer et al. β Cell Replacement for the Treatment of Diabetes
Rastellini Donor and recipient selection for islet transplantation
Salama et al. Exploring Novel Treatment Modalities for Type 1 Diabetes Mellitus: Potential and Prospects
Mamujee et al. Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Salama et al. Novel Treatment Modalities of Type 1 Diabetes Mellitus: Opportunities and Challenges
Bandeiras et al. Simulation of remodeling of tissue engineered condylar cartilage under static hydrostatic pressure
WO2004078956A3 (en) Process for detaching confluent cells from two dimensional microsupports and its application for preparing transplants
Leahy Islet transplantation: is the cure for diabetes here?