DK0716857T3 - Anvendelse af rapamycin til behandling af anæmi - Google Patents
Anvendelse af rapamycin til behandling af anæmiInfo
- Publication number
- DK0716857T3 DK0716857T3 DK95308503T DK95308503T DK0716857T3 DK 0716857 T3 DK0716857 T3 DK 0716857T3 DK 95308503 T DK95308503 T DK 95308503T DK 95308503 T DK95308503 T DK 95308503T DK 0716857 T3 DK0716857 T3 DK 0716857T3
- Authority
- DK
- Denmark
- Prior art keywords
- rapamycin
- anemia
- treatment
- mammal
- intrabronchially
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/354,977 US5561138A (en) | 1994-12-13 | 1994-12-13 | Method of treating anemia |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0716857T3 true DK0716857T3 (da) | 2002-08-05 |
Family
ID=23395715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95308503T DK0716857T3 (da) | 1994-12-13 | 1995-11-27 | Anvendelse af rapamycin til behandling af anæmi |
Country Status (12)
Country | Link |
---|---|
US (1) | US5561138A (da) |
EP (1) | EP0716857B1 (da) |
JP (1) | JPH08208661A (da) |
KR (1) | KR100423825B1 (da) |
AT (1) | ATE215822T1 (da) |
CA (1) | CA2164921A1 (da) |
DE (1) | DE69526311T2 (da) |
DK (1) | DK0716857T3 (da) |
ES (1) | ES2179862T3 (da) |
HK (1) | HK1010345A1 (da) |
MX (1) | MX9505187A (da) |
PT (1) | PT716857E (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1289815B1 (it) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US6670355B2 (en) * | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
CA2421485A1 (en) | 2000-09-19 | 2002-03-28 | Wyeth | Water soluble rapamycin esters |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
TWI296196B (en) * | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
ZA200603888B (en) * | 2001-06-01 | 2007-05-30 | Wyeth Corp | Antineoplastic combinations |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
ES2246409T3 (es) | 2001-08-22 | 2006-02-16 | Wyeth | 29-enoles de rapamicina. |
CA2455311A1 (en) | 2001-08-22 | 2003-03-06 | Wyeth | Rapamycin dialdehydes |
CN100402031C (zh) | 2002-07-30 | 2008-07-16 | 惠氏公司 | 含有瑞帕霉素羟基酯的胃肠外制剂 |
AU2003272489B2 (en) * | 2002-09-17 | 2008-11-13 | Wyeth | Granulated formulation of the rapamycin ester CCI779 |
AR042938A1 (es) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
US20040258662A1 (en) * | 2003-04-22 | 2004-12-23 | Wyeth | Antineoplastic agents |
CN101031569B (zh) | 2004-05-13 | 2011-06-22 | 艾科斯有限公司 | 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮 |
JP2008500338A (ja) * | 2004-05-25 | 2008-01-10 | イコス・コーポレイション | 造血細胞の異常増殖を治療及び/又は予防する方法 |
EP1804751A2 (en) * | 2004-10-04 | 2007-07-11 | QLT USA, Inc. | Ocular delivery of polymeric delivery formulations |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
JP5709354B2 (ja) | 2005-11-14 | 2015-04-30 | アリアド・ファーマシューティカルズ・インコーポレイテッド | mTOR阻害剤投与によるがん患者の治療 |
WO2008022256A2 (en) * | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
CN104906087A (zh) | 2006-09-13 | 2015-09-16 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
US20100086579A1 (en) * | 2008-10-03 | 2010-04-08 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
DK2365802T3 (da) | 2008-11-11 | 2017-11-13 | Univ Texas | Mikrokapsler af rapamycin og anvendelse til behandling af cancer |
US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
ES2674719T3 (es) | 2008-11-13 | 2018-07-03 | Gilead Calistoga Llc | Terapias para neoplasias hematológicas |
US8440677B2 (en) | 2009-03-24 | 2013-05-14 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
EP2965763B8 (en) * | 2009-04-10 | 2018-08-15 | Haiyan Qi | Anti-aging agents |
AU2010239312A1 (en) | 2009-04-20 | 2011-11-10 | Gilead Calistoga Llc | Methods of treatment for solid tumors |
MX2012000817A (es) | 2009-07-21 | 2012-05-08 | Gilead Calistoga Llc | Tratamiento para desordenes del higado con inhibidores pi3k. |
US9364507B2 (en) | 2009-08-11 | 2016-06-14 | Imagilin Technology, Llc | Probiotic enhancement of steroid and immune suppressor activity in mammals with chronic diseases |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
UY34656A (es) | 2012-03-05 | 2013-10-31 | Gilead Calistoga Llc | Polimorfos de (s)?2?(1?(9h?purin?6?ilamino)propil)?5?fluor?3?fenilquinazolin?4(3h)?ona, composición y método de preparación |
WO2014059295A1 (en) | 2012-10-12 | 2014-04-17 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
EP2968281B1 (en) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
EA201690990A1 (ru) | 2013-12-20 | 2016-11-30 | Джилид Калистога Ллс | Способы получения ингибиторов фосфатидилинозитол-3-киназы |
EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
BR112016028642A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. |
EP4149441A4 (en) * | 2020-05-15 | 2024-03-13 | Celgene Corp | METHODS AND COMPOSITIONS FOR TREATING ANEMIA USING ACTRIIB LIGAND TRAPS AND MTOR INHIBITORS |
CN116459248B (zh) * | 2023-04-27 | 2024-02-13 | 中国人民解放军陆军军医大学第二附属医院 | 雷帕霉素在制备治疗肿瘤相关性贫血的药物中的应用和药物 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
DE69129459T2 (de) * | 1990-08-10 | 1998-10-15 | Anormed Inc | Immunosuppressive zusammensetzungen |
US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5080899A (en) * | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
US5321009A (en) * | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
DE69209183T2 (de) | 1991-06-18 | 1996-08-08 | American Home Prod | Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen |
ZA924953B (en) * | 1991-07-25 | 1993-04-28 | Univ Louisville Res Found | Method of treating ocular inflammation |
US5286730A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
US5286731A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
US5288711A (en) * | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
GB9302567D0 (en) * | 1993-02-10 | 1993-03-24 | Smithkline Beecham Plc | Novel compound |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
-
1994
- 1994-12-13 US US08/354,977 patent/US5561138A/en not_active Expired - Lifetime
-
1995
- 1995-11-27 DE DE69526311T patent/DE69526311T2/de not_active Expired - Fee Related
- 1995-11-27 PT PT95308503T patent/PT716857E/pt unknown
- 1995-11-27 ES ES95308503T patent/ES2179862T3/es not_active Expired - Lifetime
- 1995-11-27 EP EP95308503A patent/EP0716857B1/en not_active Expired - Lifetime
- 1995-11-27 AT AT95308503T patent/ATE215822T1/de not_active IP Right Cessation
- 1995-11-27 DK DK95308503T patent/DK0716857T3/da active
- 1995-12-11 MX MX9505187A patent/MX9505187A/es unknown
- 1995-12-11 CA CA002164921A patent/CA2164921A1/en not_active Abandoned
- 1995-12-12 JP JP7323042A patent/JPH08208661A/ja active Pending
- 1995-12-12 KR KR1019950048544A patent/KR100423825B1/ko not_active IP Right Cessation
-
1998
- 1998-10-20 HK HK98111349A patent/HK1010345A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69526311D1 (de) | 2002-05-16 |
PT716857E (pt) | 2002-08-30 |
KR960021019A (ko) | 1996-07-18 |
KR100423825B1 (ko) | 2004-06-26 |
EP0716857A1 (en) | 1996-06-19 |
EP0716857B1 (en) | 2002-04-10 |
HK1010345A1 (en) | 1999-06-17 |
ES2179862T3 (es) | 2003-02-01 |
MX9505187A (es) | 1997-04-30 |
DE69526311T2 (de) | 2002-11-28 |
CA2164921A1 (en) | 1996-06-14 |
JPH08208661A (ja) | 1996-08-13 |
US5561138A (en) | 1996-10-01 |
ATE215822T1 (de) | 2002-04-15 |
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