DK0679187T3 - Fremgangsmåde til udvinding af native, oligomere, glycosolerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIV - Google Patents
Fremgangsmåde til udvinding af native, oligomere, glycosolerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIVInfo
- Publication number
- DK0679187T3 DK0679187T3 DK94904568.6T DK94904568T DK0679187T3 DK 0679187 T3 DK0679187 T3 DK 0679187T3 DK 94904568 T DK94904568 T DK 94904568T DK 0679187 T3 DK0679187 T3 DK 0679187T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- pct
- native
- ectodomains
- hiv
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108010065667 Viral Matrix Proteins Proteins 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 3
- 108020001580 protein domains Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 231100000676 disease causative agent Toxicity 0.000 abstract 1
- 108010078428 env Gene Products Proteins 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4301017 | 1993-01-16 | ||
PCT/DE1994/000022 WO1994016081A1 (de) | 1993-01-16 | 1994-01-12 | Verfahren zur gewinnung nativer domänen viraler membranproteine, deren verwendung, insbesondere als impfstoff gegen hiv |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0679187T3 true DK0679187T3 (da) | 1997-12-08 |
DK0679187T4 DK0679187T4 (da) | 2001-09-17 |
Family
ID=6478309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94904568T DK0679187T4 (da) | 1993-01-16 | 1994-01-12 | Fremgangsmåde til udvinding af native, oligomere, glycosylerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIV |
Country Status (9)
Country | Link |
---|---|
US (1) | US6140059A (da) |
EP (1) | EP0679187B2 (da) |
JP (1) | JP3658690B2 (da) |
AT (1) | ATE153380T1 (da) |
DE (2) | DE4400659C2 (da) |
DK (1) | DK0679187T4 (da) |
ES (1) | ES2102815T5 (da) |
GR (1) | GR3023717T3 (da) |
WO (1) | WO1994016081A1 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2781676B1 (fr) * | 1998-07-31 | 2004-04-02 | Pasteur Merieux Serums Vacc | Trimere du produit d'expression du gene env de hiv |
CA2358385C (en) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
WO2000039302A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
CA2358915C (en) | 1998-12-31 | 2010-06-01 | Chiron Corporation | Modified hiv env polypeptides |
EP1214333A4 (en) * | 1999-09-17 | 2005-01-19 | Dana Farber Cancer Inst Inc | STABILIZED SOLUBLE GLYCOPROTEINTRIMERE |
US7179468B1 (en) | 2000-06-08 | 2007-02-20 | Cornell Research Foundation, Inc. | Antigen for developing neutralizing antibodies to human immunodeficiency virus |
EP2412242A3 (en) | 2001-07-05 | 2012-06-13 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
WO2003004657A1 (en) * | 2001-07-05 | 2003-01-16 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof |
CA2458995C (en) * | 2001-08-31 | 2013-04-30 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
WO2004101598A2 (en) * | 2003-05-09 | 2004-11-25 | Research Development Foundation | Insertion of furin protease cleavage sites in membrane proteins and uses thereof |
US7358334B1 (en) | 2003-11-14 | 2008-04-15 | Jay W Chaplin | B cell-targeted toxins for humoral immune response reduction and methods of use thereof |
US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
WO2010104747A2 (en) | 2009-03-10 | 2010-09-16 | Baylor Research Institute | Antigen presenting cell targeted vaccines |
AU2010222928B2 (en) * | 2008-07-16 | 2012-11-29 | Baylor Research Institute | Antigen presenting cell targeted vaccines |
WO2010039224A2 (en) * | 2008-09-30 | 2010-04-08 | University Of Massachusetts Medical School | Respiratory syncytial virus (rsv) sequences for protein expression and vaccines |
DK2406286T3 (da) | 2009-03-10 | 2016-08-22 | Baylor Res Inst | Anti-cd40-antistoffer og anvendelser deraf |
EP3187585A1 (en) | 2010-03-25 | 2017-07-05 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
WO2012135132A1 (en) | 2011-03-25 | 2012-10-04 | Baylor Research Institute | Compositions and methods to immunize against hepatitis c virus |
PL2691530T3 (pl) | 2011-06-10 | 2019-02-28 | Oregon Health & Science University | Glikoproteiny i rekombinowane wektory CMV |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
JP7037884B2 (ja) | 2014-01-13 | 2022-03-17 | ベイラー リサーチ インスティテュート | Hpv及びhpv関連疾患に対する新規のワクチン |
EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3731874A1 (de) * | 1987-09-18 | 1989-03-30 | Schering Ag | Verfahren zur herstellung von peptiden durch spezifische spaltung von gentechnisch gewonnenen fusionsproteinen mit collagenasen |
IL89567A0 (en) * | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
ATE207930T1 (de) † | 1990-03-09 | 2001-11-15 | Chiron Corp | Gereinigtes gp120, in dem seine natürliche konformation erhalten bleibt |
FR2676071B1 (fr) * | 1991-05-02 | 1994-11-18 | Transgene Sa | Nouveau variant gp160 non-clivable, soluble, de forme hybride. |
-
1994
- 1994-01-12 DE DE4400659A patent/DE4400659C2/de not_active Expired - Fee Related
- 1994-01-12 ES ES94904568T patent/ES2102815T5/es not_active Expired - Lifetime
- 1994-01-12 EP EP94904568A patent/EP0679187B2/de not_active Expired - Lifetime
- 1994-01-12 AT AT94904568T patent/ATE153380T1/de not_active IP Right Cessation
- 1994-01-12 DK DK94904568T patent/DK0679187T4/da active
- 1994-01-12 DE DE59402827T patent/DE59402827D1/de not_active Expired - Fee Related
- 1994-01-12 WO PCT/DE1994/000022 patent/WO1994016081A1/de active IP Right Grant
- 1994-01-12 JP JP51558794A patent/JP3658690B2/ja not_active Expired - Fee Related
- 1994-01-12 US US08/448,619 patent/US6140059A/en not_active Expired - Fee Related
-
1997
- 1997-06-10 GR GR970401358T patent/GR3023717T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0679187B1 (de) | 1997-05-21 |
DE4400659C2 (de) | 1995-07-27 |
WO1994016081A1 (de) | 1994-07-21 |
ATE153380T1 (de) | 1997-06-15 |
DK0679187T4 (da) | 2001-09-17 |
JPH08505769A (ja) | 1996-06-25 |
US6140059A (en) | 2000-10-31 |
EP0679187B2 (de) | 2001-07-04 |
ES2102815T5 (es) | 2001-11-16 |
GR3023717T3 (en) | 1997-09-30 |
ES2102815T3 (es) | 1997-08-01 |
DE4400659A1 (de) | 1994-07-21 |
JP3658690B2 (ja) | 2005-06-08 |
EP0679187A1 (de) | 1995-11-02 |
DE59402827D1 (de) | 1997-06-26 |
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