DK0675729T3 - Aktivering af p53 protein - Google Patents

Aktivering af p53 protein

Info

Publication number
DK0675729T3
DK0675729T3 DK94900267T DK94900267T DK0675729T3 DK 0675729 T3 DK0675729 T3 DK 0675729T3 DK 94900267 T DK94900267 T DK 94900267T DK 94900267 T DK94900267 T DK 94900267T DK 0675729 T3 DK0675729 T3 DK 0675729T3
Authority
DK
Denmark
Prior art keywords
pct
activated
tumour
sec
protein
Prior art date
Application number
DK94900267T
Other languages
English (en)
Inventor
David Philip Lane
Theodore Robert Hupp
Original Assignee
Univ Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee filed Critical Univ Dundee
Application granted granted Critical
Publication of DK0675729T3 publication Critical patent/DK0675729T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Eye Examination Apparatus (AREA)
  • Micromachines (AREA)
DK94900267T 1992-11-26 1993-11-26 Aktivering af p53 protein DK0675729T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929224784A GB9224784D0 (en) 1992-11-26 1992-11-26 Cellular protein
PCT/GB1993/002438 WO1994012202A1 (en) 1992-11-26 1993-11-26 ACTIVATION OF p53 PROTEIN

Publications (1)

Publication Number Publication Date
DK0675729T3 true DK0675729T3 (da) 1999-12-06

Family

ID=10725717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94900267T DK0675729T3 (da) 1992-11-26 1993-11-26 Aktivering af p53 protein

Country Status (13)

Country Link
US (1) US6140058A (da)
EP (1) EP0675729B1 (da)
JP (1) JPH08505607A (da)
KR (1) KR100291964B1 (da)
AT (1) ATE180673T1 (da)
AU (1) AU680216B2 (da)
CA (1) CA2150265C (da)
DE (1) DE69325180T2 (da)
DK (1) DK0675729T3 (da)
ES (1) ES2134336T3 (da)
GB (1) GB9224784D0 (da)
GR (1) GR3030900T3 (da)
WO (1) WO1994012202A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573925A (en) * 1994-11-28 1996-11-12 The Wistar Institute Of Anatomy And Biology P53 proteins with altered tetramerization domains
US5721340A (en) * 1994-11-28 1998-02-24 The Wistar Institute Of Anatomy & Biology p53 proteins with altered tetramerization domains
US6169073B1 (en) 1995-02-16 2001-01-02 Bayer Corporation Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
FR2732348B1 (fr) * 1995-03-31 1997-04-30 Rhone Poulenc Rorer Sa Systeme d'expression conditionnel
FR2736915B1 (fr) * 1995-07-19 1997-08-22 Rhone Poulenc Rorer Sa Variants de la proteine p53 et utilisations therapeutiques
US5847083A (en) * 1996-08-21 1998-12-08 The Wistar Institute Of Anatomy And Biology Modified p53 constructs which enhance DNA binding
GB9521544D0 (en) * 1995-10-20 1995-12-20 Univ Dundee Activation of P53 protein and therapeutic applications thereof
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
GB9714971D0 (en) * 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
DE19735221C1 (de) * 1997-08-14 1999-05-06 Wolfgang Willi Prof Dr Deppert Beeinflussung der Bindung von p53 an Zielgene
DE19802792A1 (de) * 1998-01-26 1999-07-29 Wolfgang Willi Prof Dr Deppert Hemmung der durch mutiertes p53 verursachten Modulation von DNA
WO2000022115A2 (en) * 1998-10-13 2000-04-20 Board Of Regents, The University Of Texas System Assays for identifying functional alterations in the p53 tumor suppressor
CN1329493A (zh) * 1998-12-02 2002-01-02 辉瑞产品公司 恢复p53家族蛋白质的构象稳定性的方法和组合物
EP1480042A3 (en) * 1998-12-02 2006-06-21 Pfizer Products Inc. Method of screening compounds interacting with proteins of the p53 family
EP1854509A3 (en) * 1998-12-02 2010-08-18 Pfizer Products Inc. Methods and compositions for restoring conformational stability of a protein of the p53 family
AUPP932199A0 (en) * 1999-03-19 1999-04-15 St Vincent's Hospital Sydney Limited Anti-p53 antibodies
US6989239B2 (en) * 2001-06-20 2006-01-24 R.E.D. Laboratories, N.V./S.A. Methods for diagnosis and treatment of chronic immune diseases
AU2005276117C1 (en) 2004-08-23 2013-04-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Peptide inhibitors for mediating stress responses
US20070224662A1 (en) * 2004-12-17 2007-09-27 Jun Luo Post-translational modification of proteins in cell-free expression systems
KR100749858B1 (ko) 2005-08-12 2007-08-16 연세대학교 산학협력단 ｐ53 변이체 및 그의 용도
CA2836503C (en) 2011-05-23 2020-09-22 Yeda Research And Development Co. Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
DK3201234T3 (da) * 2014-09-30 2019-02-25 Diadem S R L Antistof der binder en lineær epitop af human p53 og diagnostiske anvendelser deraf
GB201617564D0 (en) * 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
WO2019162974A1 (en) * 2018-02-23 2019-08-29 Ulisse Biomed S.R.L. Method to diagnose cancer progression based on prokaryotic biomarkers and molecules for use in the treatment of cancer progression

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO312681B1 (no) * 1990-08-24 2002-06-17 Univ California Fremgangsmåte for fremstilling av en farmasöytisk blanding med suppresiv virkning/aktivitet
CA2118015A1 (en) * 1992-04-14 1993-10-28 Jeffrey R. Marks Method of detecting tumors containing complexes of p53 and hsp70

Also Published As

Publication number Publication date
ATE180673T1 (de) 1999-06-15
US6140058A (en) 2000-10-31
AU5533194A (en) 1994-06-22
DE69325180D1 (de) 1999-07-08
GR3030900T3 (en) 1999-11-30
ES2134336T3 (es) 1999-10-01
EP0675729B1 (en) 1999-06-02
CA2150265A1 (en) 1994-06-09
GB9224784D0 (en) 1993-01-13
DE69325180T2 (de) 1999-12-02
AU680216B2 (en) 1997-07-24
EP0675729A1 (en) 1995-10-11
WO1994012202A1 (en) 1994-06-09
JPH08505607A (ja) 1996-06-18
KR100291964B1 (ko) 2001-10-23
CA2150265C (en) 1998-12-29

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