DK0669980T3 - Fremgangsmåde til kontrol af polypeptidproduktion i bakterier - Google Patents

Fremgangsmåde til kontrol af polypeptidproduktion i bakterier

Info

Publication number
DK0669980T3
DK0669980T3 DK94901629T DK94901629T DK0669980T3 DK 0669980 T3 DK0669980 T3 DK 0669980T3 DK 94901629 T DK94901629 T DK 94901629T DK 94901629 T DK94901629 T DK 94901629T DK 0669980 T3 DK0669980 T3 DK 0669980T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
polypeptide
phosphate
psts
promoter
Prior art date
Application number
DK94901629T
Other languages
Danish (da)
English (en)
Inventor
Steven Bass
James R Swartz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0669980T3 publication Critical patent/DK0669980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK94901629T 1992-11-20 1993-11-19 Fremgangsmåde til kontrol af polypeptidproduktion i bakterier DK0669980T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/989,845 US5304472A (en) 1992-11-20 1992-11-20 Method of controlling polypeptide production in bacterial cells
PCT/US1993/011298 WO1994012636A1 (fr) 1992-11-20 1993-11-19 Procede de regulation de la production de polypeptides dans des bacteries

Publications (1)

Publication Number Publication Date
DK0669980T3 true DK0669980T3 (da) 2003-11-24

Family

ID=25535525

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94901629T DK0669980T3 (da) 1992-11-20 1993-11-19 Fremgangsmåde til kontrol af polypeptidproduktion i bakterier

Country Status (12)

Country Link
US (1) US5304472A (fr)
EP (1) EP0669980B1 (fr)
JP (1) JP3503705B2 (fr)
AT (1) ATE247167T1 (fr)
AU (1) AU671512B2 (fr)
CA (1) CA2145388C (fr)
DE (1) DE69333145T2 (fr)
DK (1) DK0669980T3 (fr)
ES (1) ES2204911T3 (fr)
IL (1) IL107564A (fr)
PT (1) PT669980E (fr)
WO (1) WO1994012636A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US6140305A (en) * 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
WO1997038123A1 (fr) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Procedes de production de proteines eucaryotes, solubles, actives sur plan biologique et contenant des liaisons disulfure, a l'interieur de cellules bacteriennes
IL129843A0 (en) * 1996-11-08 2000-02-29 Cytel Corp Improved expression vectors
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
EP1141313A2 (fr) * 1998-12-31 2001-10-10 Chiron Corporation Expression amelioree de polypeptides hiv et production de particules de type viral
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
WO2000039303A2 (fr) * 1998-12-31 2000-07-06 Chiron Corporation Polypeptides vih env modifies
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
DE10012283A1 (de) * 2000-03-14 2001-09-20 Thomas Schweder Wirts-Vektor-Systeme zur phosphatregulierten Überproduktion von Polypeptiden in Becillus
EP2292772A1 (fr) * 2001-07-05 2011-03-09 Novartis Vaccines and Diagnostics, Inc. Vaccination VIH avec un ADN codant un polypeptide VIH et un polypeptide VIH
AU2002320314A1 (en) * 2001-07-05 2003-01-21 Chiron, Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US7858762B2 (en) 2001-07-30 2010-12-28 Genencor International, Inc. Phosphate limited inducible promoter and a Bacillus expression system
WO2003020876A2 (fr) 2001-08-31 2003-03-13 Chiron Corporation Polynucleotides codant des polypeptides de type b du vih antigeniques, polypeptides et leurs utilisations
US20030170614A1 (en) * 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
DK1432793T3 (da) * 2001-09-13 2009-12-07 Genentech Inc Aminopeptidase b2324
GB0224082D0 (en) * 2002-10-16 2002-11-27 Celltech R&D Ltd Biological products
WO2004081033A2 (fr) * 2003-03-11 2004-09-23 National Institutes Of Health Synthese de proteines au moyen d'une expression proteique exempte de cellule
AU2012203817B2 (en) * 2004-03-11 2015-05-28 Genentech, Inc. Process for producing polypeptides
CA2558911C (fr) * 2004-03-11 2016-12-06 Genentech, Inc. Procede de fabrication de polypeptides
CN101128586A (zh) 2004-12-22 2008-02-20 健泰科生物技术公司 制备可溶性多跨膜蛋白的方法
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
US20080213811A1 (en) * 2006-08-11 2008-09-04 Invitrogen Corporation Sensor proteins and assay methods
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
EP2546267A1 (fr) 2011-07-13 2013-01-16 UCB Pharma S.A. Souche hôte bactérienne exprimant un DsbC recombinant
CN103649124B (zh) 2011-07-13 2016-04-13 Ucb医药有限公司 表达重组dsbc的细菌宿主菌株
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
EP2970869A4 (fr) * 2013-03-14 2016-08-03 Codexis Inc Promoteur répressible à faible teneur en phosphate
KR102185850B1 (ko) * 2020-02-21 2020-12-02 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS592689A (ja) * 1982-06-04 1984-01-09 Handai Biseibutsubiyou Kenkyukai 強力な遺伝子発現能を有する新規レプリコンの作成法
FR2575760A1 (fr) * 1985-01-04 1986-07-11 Merieux Inst Nouvelles souches d'escherichia coli excretrices de phosphatase alcaline, procede d'obtention de ces souches, procede de production de phosphatase alcaline et de proteines hybrides derivees
JPS61280292A (ja) * 1985-06-04 1986-12-10 Wakunaga Pharmaceut Co Ltd 菌体外分泌による蛋白質の製造法
FR2599380A1 (fr) * 1986-05-29 1987-12-04 Centre Nat Rech Scient Vecteur d'exportation de proteines chez escherichiacoli, bacteries transformees et procede pour la preparation de proteines
FR2606031A1 (fr) * 1986-11-03 1988-05-06 Merieux Inst Nouvelles souches d'escherichia coli hyperproductrices et/ou hyperexcretrices de proteines exportees, procede d'obtention de ces souches, et application a la production de proteines
DE69127482T2 (de) * 1990-02-07 1998-03-19 Abbott Lab Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien

Also Published As

Publication number Publication date
EP0669980A1 (fr) 1995-09-06
WO1994012636A1 (fr) 1994-06-09
JPH08503612A (ja) 1996-04-23
IL107564A0 (en) 1994-02-27
ES2204911T3 (es) 2004-05-01
US5304472A (en) 1994-04-19
CA2145388C (fr) 2004-08-10
ATE247167T1 (de) 2003-08-15
AU671512B2 (en) 1996-08-29
DE69333145D1 (de) 2003-09-18
JP3503705B2 (ja) 2004-03-08
PT669980E (pt) 2003-12-31
IL107564A (en) 2000-08-31
DE69333145T2 (de) 2004-06-17
CA2145388A1 (fr) 1994-06-09
EP0669980B1 (fr) 2003-08-13
AU5615194A (en) 1994-06-22

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