DK0666850T3 - Derivater af 1,2,3,5,6,7,8,8a-octahydro-5, 5 , 8a-trimethyl-(8abeta)-6-isoquinolinamin, deres fremstillingsmåde og terapeutiske anvendelse - Google Patents
Derivater af 1,2,3,5,6,7,8,8a-octahydro-5, 5 , 8a-trimethyl-(8abeta)-6-isoquinolinamin, deres fremstillingsmåde og terapeutiske anvendelseInfo
- Publication number
- DK0666850T3 DK0666850T3 DK93923582.6T DK93923582T DK0666850T3 DK 0666850 T3 DK0666850 T3 DK 0666850T3 DK 93923582 T DK93923582 T DK 93923582T DK 0666850 T3 DK0666850 T3 DK 0666850T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- octahydro
- trimethyl
- 8abeta
- isoquinolinamine
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- PUERAZFQIXLYDR-CQNOQWDGSA-N 3-[(4e,8e,12e,16e)-4,8,13,17,21-pentamethyldocosa-4,8,12,16,20-pentaenylidene]oxetane Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CCC=C1COC1 PUERAZFQIXLYDR-CQNOQWDGSA-N 0.000 abstract 1
- 101710095468 Cyclase Proteins 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9212865A FR2697252B1 (fr) | 1992-10-28 | 1992-10-28 | Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0666850T3 true DK0666850T3 (da) | 1997-07-28 |
Family
ID=9434930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93923582.6T DK0666850T3 (da) | 1992-10-28 | 1993-10-18 | Derivater af 1,2,3,5,6,7,8,8a-octahydro-5, 5 , 8a-trimethyl-(8abeta)-6-isoquinolinamin, deres fremstillingsmåde og terapeutiske anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5580881A (de) |
| EP (1) | EP0666850B1 (de) |
| JP (1) | JPH08504402A (de) |
| AT (1) | ATE148693T1 (de) |
| CA (1) | CA2148002A1 (de) |
| DE (1) | DE69308029T2 (de) |
| DK (1) | DK0666850T3 (de) |
| ES (1) | ES2098790T3 (de) |
| FR (1) | FR2697252B1 (de) |
| GR (1) | GR3023266T3 (de) |
| WO (1) | WO1994010150A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341066A1 (de) * | 1993-05-03 | 1994-11-10 | Bayer Ag | Oxa(Thia)-diazol-oxy-phenylacrylate |
| US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| CA2260872A1 (en) * | 1996-08-14 | 1998-02-19 | Elaine Sophie Elizabeth Stokes | Substituted pyrimidine derivatives and their pharmaceutical use |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| EP0966460A1 (de) | 1997-02-13 | 1999-12-29 | Zeneca Limited | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren verwendung finden |
| AU5999798A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| US20040204450A1 (en) * | 2003-03-28 | 2004-10-14 | Pfizer Inc | Quinoline and quinoxaline compounds |
| CN101119970A (zh) * | 2004-01-09 | 2008-02-06 | 科赛普特治疗学股份有限公司 | 氮杂萘烷糖皮质激素受体调节剂 |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2008045564A2 (en) * | 2006-10-12 | 2008-04-17 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
| RU2010128543A (ru) | 2007-12-11 | 2012-01-20 | Сайтопатфайндер, Инк. (Jp) | Карбоксамидные соединения и их применение в качестве агонистов хемокиновых рецепторов |
| WO2011145022A1 (en) | 2010-05-21 | 2011-11-24 | Pfizer Inc. | 2-phenyl benzoylamides |
| EP2680874A2 (de) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-ähnliche peptide und ihre verwendung |
| WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| PL3848027T3 (pl) | 2013-11-25 | 2023-07-24 | Corcept Therapeutics Incorporated | Skondensowane oktahydrozwiązki azadekaliny jako modulatory receptora glukokortykoidowego |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN113574055A (zh) | 2019-01-18 | 2021-10-29 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
| BR112021015129A2 (pt) | 2019-02-22 | 2021-09-28 | Corcept Therapeutics Incorporated | Método para tratar um paciente que sofre de hipercortisolemia e um sintoma ou comorbidade da mesma |
| EP4072556A4 (de) | 2019-12-11 | 2024-01-03 | Corcept Therapeutics Incorporated | Verfahren zur behandlung von antipsychotikainduzierter gewichtszunahme mit miricorilant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863932A (en) * | 1988-03-11 | 1989-09-05 | Somatogenetics International, Inc. | Squalene oxide cyclase inhibitors and therapeutic use thereof |
| US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
-
1992
- 1992-10-28 FR FR9212865A patent/FR2697252B1/fr not_active Expired - Fee Related
-
1993
- 1993-10-18 WO PCT/FR1993/001022 patent/WO1994010150A1/fr active IP Right Grant
- 1993-10-18 ES ES93923582T patent/ES2098790T3/es not_active Expired - Lifetime
- 1993-10-18 CA CA002148002A patent/CA2148002A1/en not_active Abandoned
- 1993-10-18 US US08/424,419 patent/US5580881A/en not_active Expired - Fee Related
- 1993-10-18 DE DE69308029T patent/DE69308029T2/de not_active Expired - Fee Related
- 1993-10-18 JP JP6510756A patent/JPH08504402A/ja active Pending
- 1993-10-18 AT AT93923582T patent/ATE148693T1/de active
- 1993-10-18 DK DK93923582.6T patent/DK0666850T3/da active
- 1993-10-18 EP EP93923582A patent/EP0666850B1/de not_active Expired - Lifetime
-
1997
- 1997-04-23 GR GR970400933T patent/GR3023266T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994010150A1 (fr) | 1994-05-11 |
| DE69308029D1 (de) | 1997-03-20 |
| GR3023266T3 (en) | 1997-07-30 |
| CA2148002A1 (en) | 1994-05-11 |
| DE69308029T2 (de) | 1997-08-14 |
| FR2697252B1 (fr) | 1994-12-09 |
| ES2098790T3 (es) | 1997-05-01 |
| US5580881A (en) | 1996-12-03 |
| EP0666850A1 (de) | 1995-08-16 |
| ATE148693T1 (de) | 1997-02-15 |
| FR2697252A1 (fr) | 1994-04-29 |
| JPH08504402A (ja) | 1996-05-14 |
| EP0666850B1 (de) | 1997-02-05 |
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