DK0654041T3 - Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler - Google Patents
Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midlerInfo
- Publication number
- DK0654041T3 DK0654041T3 DK93912277T DK93912277T DK0654041T3 DK 0654041 T3 DK0654041 T3 DK 0654041T3 DK 93912277 T DK93912277 T DK 93912277T DK 93912277 T DK93912277 T DK 93912277T DK 0654041 T3 DK0654041 T3 DK 0654041T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- difluoro
- oxo
- amino
- hexanedioic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92288992A | 1992-07-31 | 1992-07-31 | |
PCT/US1993/003589 WO1994003480A1 (fr) | 1992-07-31 | 1993-04-21 | Derives de l'acide peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexane-dioïque utilises comme agents antiinflammatoires |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0654041T3 true DK0654041T3 (da) | 1998-10-26 |
Family
ID=25447720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912277T DK0654041T3 (da) | 1992-07-31 | 1993-04-21 | Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler |
Country Status (10)
Country | Link |
---|---|
US (1) | US5739279A (fr) |
EP (1) | EP0654041B1 (fr) |
JP (1) | JP2602181B2 (fr) |
AT (1) | ATE167872T1 (fr) |
CA (1) | CA2139854A1 (fr) |
DE (1) | DE69319432T2 (fr) |
DK (1) | DK0654041T3 (fr) |
ES (1) | ES2117133T3 (fr) |
FI (1) | FI933424A (fr) |
WO (1) | WO1994003480A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6162828A (en) * | 1995-03-31 | 2000-12-19 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
US5968927A (en) | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
DE69925581T2 (de) | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms |
KR100928878B1 (ko) | 1998-03-19 | 2009-11-30 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제의 억제제 |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US20030114362A1 (en) * | 2001-06-08 | 2003-06-19 | Novaspin Biotech Gmbh | Penta-or tetrapeptide binding to somatostatin receptors and the use of the same |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
FR2842810B1 (fr) * | 2002-07-25 | 2006-01-27 | Inst Nat Sciences Appliq | Nouveaux composes gem difluores, leur procedes de preparation et leurs applications. |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
EP1778221A2 (fr) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Traitement de maladies autoinflammatopires a l'aide d'inhibiteurs de l'ice |
EP2671508B1 (fr) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Système pharma-informatique |
CA2663377A1 (fr) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Traitement des troubles hepatiques par l'administration de conjugues de proteine associee au recepteur (rap) |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
WO1991015577A1 (fr) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
-
1993
- 1993-04-21 JP JP6505261A patent/JP2602181B2/ja not_active Expired - Lifetime
- 1993-04-21 DK DK93912277T patent/DK0654041T3/da active
- 1993-04-21 WO PCT/US1993/003589 patent/WO1994003480A1/fr active IP Right Grant
- 1993-04-21 DE DE69319432T patent/DE69319432T2/de not_active Expired - Fee Related
- 1993-04-21 EP EP93912277A patent/EP0654041B1/fr not_active Expired - Lifetime
- 1993-04-21 AT AT93912277T patent/ATE167872T1/de not_active IP Right Cessation
- 1993-04-21 ES ES93912277T patent/ES2117133T3/es not_active Expired - Lifetime
- 1993-04-21 US US08/373,278 patent/US5739279A/en not_active Expired - Fee Related
- 1993-04-21 CA CA002139854A patent/CA2139854A1/fr not_active Abandoned
- 1993-07-30 FI FI933424A patent/FI933424A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
ES2117133T3 (es) | 1998-08-01 |
US5739279A (en) | 1998-04-14 |
DE69319432D1 (de) | 1998-08-06 |
WO1994003480A1 (fr) | 1994-02-17 |
DE69319432T2 (de) | 1998-10-29 |
ATE167872T1 (de) | 1998-07-15 |
CA2139854A1 (fr) | 1994-02-17 |
JP2602181B2 (ja) | 1997-04-23 |
EP0654041B1 (fr) | 1998-07-01 |
FI933424A (fi) | 1994-02-01 |
FI933424A0 (fi) | 1993-07-30 |
JPH07504686A (ja) | 1995-05-25 |
EP0654041A1 (fr) | 1995-05-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0654041T3 (da) | Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler | |
FI932229A (fi) | Azabicykliska bryggderivat | |
GR3021404T3 (en) | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation. | |
ATE202337T1 (de) | Cyclopropylalkansäurederivate | |
DK0591333T3 (da) | Azanorbornanderivater | |
DK0894084T3 (da) | Kanelsyrederivater og deres anvendelse som integrinantagonister | |
ES2092113T3 (es) | Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno. | |
FI943931A0 (fi) | Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina | |
DK0646110T3 (da) | N-substituerede 3-azabicyclo(3.2.0) heptanderivater som neuroleptika | |
ITMI922742A1 (it) | Composti ad attivita' terapeutica utili per il trattamento di malattie connesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. | |
ATE171939T1 (de) | Phenoxyphenylcyclopentenyl-hydroxyharnstoffe | |
FR2642648B1 (fr) | Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique | |
IT1179601B (it) | Composto e composizione farmaceutica ad azione anticonvulsiva particolarmente per il trattamento della epilessia |