DK0654041T3 - Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler - Google Patents

Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler

Info

Publication number
DK0654041T3
DK0654041T3 DK93912277T DK93912277T DK0654041T3 DK 0654041 T3 DK0654041 T3 DK 0654041T3 DK 93912277 T DK93912277 T DK 93912277T DK 93912277 T DK93912277 T DK 93912277T DK 0654041 T3 DK0654041 T3 DK 0654041T3
Authority
DK
Denmark
Prior art keywords
pct
difluoro
oxo
amino
hexanedioic acid
Prior art date
Application number
DK93912277T
Other languages
Danish (da)
English (en)
Inventor
Ralph Pelton Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0654041T3 publication Critical patent/DK0654041T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK93912277T 1992-07-31 1993-04-21 Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler DK0654041T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92288992A 1992-07-31 1992-07-31
PCT/US1993/003589 WO1994003480A1 (en) 1992-07-31 1993-04-21 Peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid derivatives as antiinflammatory agents

Publications (1)

Publication Number Publication Date
DK0654041T3 true DK0654041T3 (da) 1998-10-26

Family

ID=25447720

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912277T DK0654041T3 (da) 1992-07-31 1993-04-21 Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler

Country Status (10)

Country Link
US (1) US5739279A (de)
EP (1) EP0654041B1 (de)
JP (1) JP2602181B2 (de)
AT (1) ATE167872T1 (de)
CA (1) CA2139854A1 (de)
DE (1) DE69319432T2 (de)
DK (1) DK0654041T3 (de)
ES (1) ES2117133T3 (de)
FI (1) FI933424A (de)
WO (1) WO1994003480A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
CA2215211A1 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US5968927A (en) 1996-09-20 1999-10-19 Idun Pharmaceuticals, Inc. Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US6184244B1 (en) * 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
DE69925581T2 (de) 1998-03-09 2006-04-27 Vertex Pharmaceuticals Inc., Cambridge 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
EP2261235A3 (de) 1998-03-19 2011-04-20 Vertex Pharmaceuticals Incorporated Caspase-Hemmer
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US20030114362A1 (en) * 2001-06-08 2003-06-19 Novaspin Biotech Gmbh Penta-or tetrapeptide binding to somatostatin receptors and the use of the same
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
FR2842810B1 (fr) * 2002-07-25 2006-01-27 Inst Nat Sciences Appliq Nouveaux composes gem difluores, leur procedes de preparation et leurs applications.
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
EP2295054A1 (de) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice-hemmer zur Behandlung von autoinflammatorischen Erkrankungen
PL1889198T3 (pl) 2005-04-28 2015-04-30 Proteus Digital Health Inc System farmakologiczno-informatyczny
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
WO1991015577A1 (en) * 1990-04-04 1991-10-17 Black, Roy, A. INTERLEUKIN 1'beta' PROTEASE

Also Published As

Publication number Publication date
WO1994003480A1 (en) 1994-02-17
DE69319432D1 (de) 1998-08-06
EP0654041B1 (de) 1998-07-01
JP2602181B2 (ja) 1997-04-23
JPH07504686A (ja) 1995-05-25
FI933424A0 (fi) 1993-07-30
US5739279A (en) 1998-04-14
FI933424A (fi) 1994-02-01
ATE167872T1 (de) 1998-07-15
EP0654041A1 (de) 1995-05-24
ES2117133T3 (es) 1998-08-01
DE69319432T2 (de) 1998-10-29
CA2139854A1 (en) 1994-02-17

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