DK0623122T3 - Benzopyran og beslægtede LTB4-antagonister - Google Patents

Benzopyran og beslægtede LTB4-antagonister

Info

Publication number
DK0623122T3
DK0623122T3 DK92921463.3T DK92921463T DK0623122T3 DK 0623122 T3 DK0623122 T3 DK 0623122T3 DK 92921463 T DK92921463 T DK 92921463T DK 0623122 T3 DK0623122 T3 DK 0623122T3
Authority
DK
Denmark
Prior art keywords
benzopyran
ltb4 antagonists
related ltb4
antagonists
ltb4
Prior art date
Application number
DK92921463.3T
Other languages
Danish (da)
English (en)
Inventor
Kevin Koch
Lawrence S Melvin Jr
Lawrence A Reiter
Sally G Ruggeri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0623122T3 publication Critical patent/DK0623122T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK92921463.3T 1992-01-23 1992-10-13 Benzopyran og beslægtede LTB4-antagonister DK0623122T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28

Publications (1)

Publication Number Publication Date
DK0623122T3 true DK0623122T3 (da) 1997-04-21

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921463.3T DK0623122T3 (da) 1992-01-23 1992-10-13 Benzopyran og beslægtede LTB4-antagonister

Country Status (27)

Country Link
US (1) US5550152A (pt)
EP (1) EP0623122B1 (pt)
JP (1) JP2813464B2 (pt)
KR (1) KR950700274A (pt)
CN (1) CN1074681A (pt)
AP (1) AP385A (pt)
AT (1) ATE149493T1 (pt)
AU (1) AU2773392A (pt)
BG (1) BG98873A (pt)
BR (1) BR9207064A (pt)
CA (1) CA2117349C (pt)
CZ (1) CZ395492A3 (pt)
DE (1) DE69217998T2 (pt)
DK (1) DK0623122T3 (pt)
ES (1) ES2098547T3 (pt)
FI (1) FI943473A (pt)
GR (1) GR3022999T3 (pt)
HU (1) HUT67929A (pt)
IL (1) IL104421A0 (pt)
IS (1) IS3968A (pt)
MX (1) MX9300313A (pt)
NO (1) NO942758D0 (pt)
OA (1) OA10713A (pt)
PT (1) PT101182A (pt)
TW (1) TW213456B (pt)
UY (1) UY23537A1 (pt)
WO (1) WO1993015066A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
AU696890B2 (en) * 1994-10-13 1998-09-24 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists
KR100232340B1 (ko) * 1994-10-13 1999-12-01 디. 제이. 우드, 스피겔 알렌 제이 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
ATE249452T1 (de) * 1996-09-16 2003-09-15 Pfizer Verfahren und zwischenprodukte zur herstellung substituierter chromanolderivate
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
US6770259B2 (en) 2000-11-03 2004-08-03 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
BR0206771A (pt) * 2001-01-30 2004-02-25 Pfizer Prod Inc Processos para a preparação de cidos cromanilbenzóicos
KR20070035101A (ko) * 2004-07-22 2007-03-29 파마시아 코포레이션 Cox-2 선택적 억제제 및 ltb4 수용체 길항제의조합을 이용한 염증 및 통증 치료 조성물
DK2089367T3 (da) * 2006-10-31 2012-02-06 Pfizer Prod Inc Pyrazolinforbindelser som mineralocorticoidreceptor-antagonister
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
JP6590224B2 (ja) * 2014-11-11 2019-10-16 学校法人順天堂 加齢黄斑変性症予防又は治療剤
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
KR950700274A (ko) 1995-01-16
DE69217998T2 (de) 1997-06-12
GR3022999T3 (en) 1997-07-30
OA10713A (en) 2002-12-04
BG98873A (en) 1995-03-31
HU9402163D0 (en) 1994-09-28
WO1993015066A1 (en) 1993-08-05
AU2773392A (en) 1993-09-01
NO942758L (no) 1994-07-22
JPH07503464A (ja) 1995-04-13
EP0623122A1 (en) 1994-11-09
IS3968A (is) 1993-07-24
ES2098547T3 (es) 1997-05-01
ATE149493T1 (de) 1997-03-15
EP0623122B1 (en) 1997-03-05
FI943473A0 (fi) 1994-07-22
CN1074681A (zh) 1993-07-28
MX9300313A (es) 1994-06-30
CA2117349A1 (en) 1993-08-05
AP9200441A0 (en) 1993-01-31
CA2117349C (en) 2000-02-29
PT101182A (pt) 1994-03-31
TW213456B (pt) 1993-09-21
US5550152A (en) 1996-08-27
DE69217998D1 (de) 1997-04-10
CZ395492A3 (en) 1994-03-16
HUT67929A (en) 1995-05-29
UY23537A1 (es) 1993-06-28
NO942758D0 (no) 1994-07-22
JP2813464B2 (ja) 1998-10-22
AP385A (en) 1995-05-15
BR9207064A (pt) 1995-12-19
FI943473A (fi) 1994-07-22
IL104421A0 (en) 1993-05-13

Similar Documents

Publication Publication Date Title
DK0623122T3 (da) Benzopyran og beslægtede LTB4-antagonister
NO961425D0 (no) 1N-alkyl-N-arylpyrimidinaminer og derivater derav
DE59208263D1 (de) 3-Aryl-4-hydroxy-delta3-dihydrofuranon- und 3-Aryl-4-hydroxy-delta3-dihydrothiophenon-Derivate
NO943763D0 (no) 4-arylamino-benzopyraner og beslektede forbindelser
PT551048E (pt) Derivados de 2-imidazolina-5-ona e 2-imidazolina-5-tionas fungicidas
DK0623123T3 (da) Benzopyran og beslægtede LTB4-antagonister
NO922934D0 (no) Cykloheksan- og tetrahydropyranderivater
BR9205281A (pt) Pentapeptideos imuno-reguladores e neuro-reguladores
FI1031U1 (fi) En troakar
ITMI921571A1 (it) Azaciclo e azabiciclo alchiliden idrossilamine
LV10955A (lv) Benzopirana atvasinajumi
DE69226430D1 (de) Fungizide 4-thioxooxazolidin-2-one und 4-iminooxazolidin-2-one
FI925468A (fi) Kinolylmetoxifenylaettiksyraacylamider och -ureor
DK619589D0 (da) Sphingenin og derivater heraf
DK94288D0 (da) Stillads og stilladsbuk dertil
ITMI931648A1 (it) Azaciclo e azabiciclo ammidi
IT8812575A0 (it) Parallelografo e tecnigrafo