DK0592566T3 - IL-6-muteiner med reduceret cysteinantal - Google Patents

IL-6-muteiner med reduceret cysteinantal

Info

Publication number
DK0592566T3
DK0592566T3 DK92915014T DK92915014T DK0592566T3 DK 0592566 T3 DK0592566 T3 DK 0592566T3 DK 92915014 T DK92915014 T DK 92915014T DK 92915014 T DK92915014 T DK 92915014T DK 0592566 T3 DK0592566 T3 DK 0592566T3
Authority
DK
Denmark
Prior art keywords
muteins
positions
reduced cysteine
native
occur
Prior art date
Application number
DK92915014T
Other languages
Danish (da)
English (en)
Inventor
Susan M Skelly
Charles T Tackney
John N Snouwaert
Dana M Fowlkes
Original Assignee
Imclone Systems Inc
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc, Univ North Carolina filed Critical Imclone Systems Inc
Application granted granted Critical
Publication of DK0592566T3 publication Critical patent/DK0592566T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
DK92915014T 1991-07-02 1992-07-02 IL-6-muteiner med reduceret cysteinantal DK0592566T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72469891A 1991-07-02 1991-07-02
PCT/US1992/005612 WO1993001212A1 (en) 1991-07-02 1992-07-02 Cysteine depleted il-6 muteins

Publications (1)

Publication Number Publication Date
DK0592566T3 true DK0592566T3 (da) 1999-12-13

Family

ID=24911511

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92915014T DK0592566T3 (da) 1991-07-02 1992-07-02 IL-6-muteiner med reduceret cysteinantal

Country Status (18)

Country Link
US (2) US5359034A (ja)
EP (1) EP0592566B1 (ja)
JP (1) JPH07502162A (ja)
AT (1) ATE183775T1 (ja)
AU (1) AU2308992A (ja)
CA (1) CA2111327A1 (ja)
DE (1) DE69229862T2 (ja)
DK (1) DK0592566T3 (ja)
ES (1) ES2138973T3 (ja)
GR (1) GR3031927T3 (ja)
IE (1) IE922153A1 (ja)
IL (1) IL102346A0 (ja)
MX (1) MX9203879A (ja)
NZ (1) NZ243290A (ja)
PT (1) PT100651A (ja)
TW (1) TW275066B (ja)
WO (1) WO1993001212A1 (ja)
ZA (1) ZA924674B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003492A1 (en) * 1992-08-06 1994-02-17 The University Of Melbourne Interleukin-6 variants and uses therefor
AU687763B2 (en) * 1992-10-20 1998-03-05 Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service Interleukin-6 receptor antagonists
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
AU6028396A (en) * 1995-06-07 1996-12-30 Amgen, Inc. Ob protein compositions and method
US5854398A (en) * 1996-07-25 1998-12-29 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
US5861500A (en) * 1996-07-25 1999-01-19 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
AU735459B2 (en) 1997-01-30 2001-07-12 University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
US7939634B2 (en) * 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
WO2006072954A2 (en) * 2005-01-05 2006-07-13 Compugen Ltd. Novel il-6 polynucleotides encoding variant il-6 polypeptides and methods using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
AU639428B2 (en) * 1988-12-01 1993-07-29 Imclone Systems, Inc. Synthetic interleukin-6

Also Published As

Publication number Publication date
EP0592566B1 (en) 1999-08-25
US5359034A (en) 1994-10-25
DE69229862D1 (de) 1999-09-30
MX9203879A (es) 1994-01-31
DE69229862T2 (de) 2000-01-13
EP0592566A4 (en) 1995-05-24
PT100651A (pt) 1993-09-30
NZ243290A (en) 1995-04-27
US5545537A (en) 1996-08-13
CA2111327A1 (en) 1993-01-21
AU2308992A (en) 1993-02-11
EP0592566A1 (en) 1994-04-20
GR3031927T3 (en) 2000-03-31
ES2138973T3 (es) 2000-02-01
ATE183775T1 (de) 1999-09-15
TW275066B (ja) 1996-05-01
WO1993001212A1 (en) 1993-01-21
IL102346A0 (en) 1993-01-14
JPH07502162A (ja) 1995-03-09
IE922153A1 (en) 1993-01-13
ZA924674B (en) 1993-04-28

Similar Documents

Publication Publication Date Title
DK0592566T3 (da) IL-6-muteiner med reduceret cysteinantal
DE69032086D1 (de) Zytotoxischer Lymphozyten-Reifefaktor
DE3876401D1 (de) N-terminale fragmente von menschlichem serumalbumin.
MY102806A (en) Human interleukin-3 and muteins thereof
ES2073735T3 (es) Nuevos analogos de la cadena b del factor de crecimiento derivado de plaquetas y metodo para su produccion homogenea.
SE9002589D0 (sv) Neutrofil-aktiverande peptid-2
DE69024104D1 (de) Polypeptide und Polypeptidanaloge mit inhibitorischer Aktivität gegenüber menschlicher Elastase
KR870000356A (ko) 메티오닐 단백질로부터 n-말단 메티오닌을 제거하는 방법
DE68917837D1 (de) Peptid-Verbindungen.
EP0212912A3 (en) Calcitonin analogs with c-therminal d-amino acid substituents
ES2033212A6 (es) Procedimiento para la obtencion de peptidos puramente glicosilados, parcialmente glicosilados o no glicosilados.
IL82654A0 (en) Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ATE145939T1 (de) Mitogen für die glatte muskulatur und dessen kodierende dns
DK0540560T3 (da) Ancrod-lignende proteiner, fremstilling og anvendelse deraf
ATE432985T1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
BG60657B2 (en) Human recombinant interleukin-2 muteins