DK0592446T3 - Fyldningsteknik til fremstilling af lægemiddelholdige liposomer - Google Patents

Fyldningsteknik til fremstilling af lægemiddelholdige liposomer

Info

Publication number
DK0592446T3
DK0592446T3 DK92904373.5T DK92904373T DK0592446T3 DK 0592446 T3 DK0592446 T3 DK 0592446T3 DK 92904373 T DK92904373 T DK 92904373T DK 0592446 T3 DK0592446 T3 DK 0592446T3
Authority
DK
Denmark
Prior art keywords
drug
membrane permeability
preparation
cationic
anionic
Prior art date
Application number
DK92904373.5T
Other languages
Danish (da)
English (en)
Inventor
Eric A Forssen
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0592446T3 publication Critical patent/DK0592446T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92904373.5T 1991-07-03 1991-07-03 Fyldningsteknik til fremstilling af lægemiddelholdige liposomer DK0592446T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1991/004807 WO1993000888A1 (en) 1991-07-03 1991-07-03 Loading technique for preparing drug containing liposomes
EP92904373A EP0592446B1 (de) 1991-07-03 1991-07-03 Beladungstechnik zur herstellung arzneistoffhaltiger liposomen

Publications (1)

Publication Number Publication Date
DK0592446T3 true DK0592446T3 (da) 1996-01-29

Family

ID=25676859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92904373.5T DK0592446T3 (da) 1991-07-03 1991-07-03 Fyldningsteknik til fremstilling af lægemiddelholdige liposomer

Country Status (10)

Country Link
EP (1) EP0592446B1 (de)
JP (1) JPH06511470A (de)
AT (1) ATE128621T1 (de)
AU (1) AU654835B2 (de)
CA (1) CA2111593A1 (de)
DE (1) DE69113640T2 (de)
DK (1) DK0592446T3 (de)
ES (1) ES2078034T3 (de)
GR (1) GR3017836T3 (de)
WO (1) WO1993000888A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
WO1996032930A1 (en) * 1995-04-18 1996-10-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
JP4467789B2 (ja) 1997-09-18 2010-05-26 パシラ ファーマシューティカルズ インコーポレーテッド 持続放出性リポソーム麻酔組成物
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
IL135989A0 (en) 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
JP4649841B2 (ja) * 2004-02-18 2011-03-16 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
ES2967961T3 (es) 2004-05-03 2024-05-06 Ipsen Biopharm Ltd Liposomas útiles en la administración de fármacos
BRPI0516265A (pt) 2004-10-06 2008-08-26 Bc Cancer Agency composição, uso da mesma, método de aumentar a retenção de um agente terapêutico dentro dos lipossomas, formulação lipossomal, e, uso de um agente terapêutico encapsulado lipossomalmente
US20150004219A1 (en) 2012-02-02 2015-01-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Stable liposomes for drug delivery
EP3115039B1 (de) * 2015-07-09 2021-12-15 beniag GmbH Verfahren zum herstellen einer fusionsmischung zur übertragung eines geladenen moleküls in und/oder durch eine lipidmembran
BR122021024957B1 (pt) 2015-10-16 2023-12-12 Ipsen Biopharm Ltd Processos de produção de uma composição de irinotecano lipossômico estabilizado em armazenamento
US11964050B2 (en) 2017-07-24 2024-04-23 Pharmosa Biopharm Inc. Liposome compositions comprising weak acid drugs and uses thereof
WO2020102605A1 (en) * 2018-11-15 2020-05-22 The Regents Of The University Of California Vesicle-coated fibers and methods of making and using
NL2023066B1 (en) * 2019-05-03 2020-11-30 Curesupport Holding B V Stabilized liposomes
US12023394B2 (en) * 2020-05-05 2024-07-02 The Regents Of The University Of California Vesicle-coated fibers made from crosslinked lipids
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
DK0478702T3 (da) * 1989-06-22 1995-02-13 Nexstar Pharmaceuticals Inc Indkapslingsproces

Also Published As

Publication number Publication date
EP0592446B1 (de) 1995-10-04
AU9178091A (en) 1993-02-11
DE69113640D1 (de) 1995-11-09
GR3017836T3 (en) 1996-01-31
DE69113640T2 (de) 1996-03-07
AU654835B2 (en) 1994-11-24
CA2111593A1 (en) 1993-01-21
EP0592446A1 (de) 1994-04-20
WO1993000888A1 (en) 1993-01-21
JPH06511470A (ja) 1994-12-22
ES2078034T3 (es) 1995-12-01
ATE128621T1 (de) 1995-10-15

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