DE69113640D1 - Beladungstechnik zur herstellung arzneistoffhaltiger liposomen. - Google Patents

Beladungstechnik zur herstellung arzneistoffhaltiger liposomen.

Info

Publication number
DE69113640D1
DE69113640D1 DE69113640T DE69113640T DE69113640D1 DE 69113640 D1 DE69113640 D1 DE 69113640D1 DE 69113640 T DE69113640 T DE 69113640T DE 69113640 T DE69113640 T DE 69113640T DE 69113640 D1 DE69113640 D1 DE 69113640D1
Authority
DE
Germany
Prior art keywords
membrane permeability
production
cationic
anionic
liposomes containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113640T
Other languages
English (en)
Other versions
DE69113640T2 (de
Inventor
Eric Forssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Publication of DE69113640D1 publication Critical patent/DE69113640D1/de
Application granted granted Critical
Publication of DE69113640T2 publication Critical patent/DE69113640T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69113640T 1991-07-03 1991-07-03 Beladungstechnik zur herstellung arzneistoffhaltiger liposomen. Expired - Fee Related DE69113640T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/004807 WO1993000888A1 (en) 1991-07-03 1991-07-03 Loading technique for preparing drug containing liposomes

Publications (2)

Publication Number Publication Date
DE69113640D1 true DE69113640D1 (de) 1995-11-09
DE69113640T2 DE69113640T2 (de) 1996-03-07

Family

ID=25676859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113640T Expired - Fee Related DE69113640T2 (de) 1991-07-03 1991-07-03 Beladungstechnik zur herstellung arzneistoffhaltiger liposomen.

Country Status (10)

Country Link
EP (1) EP0592446B1 (de)
JP (1) JPH06511470A (de)
AT (1) ATE128621T1 (de)
AU (1) AU654835B2 (de)
CA (1) CA2111593A1 (de)
DE (1) DE69113640T2 (de)
DK (1) DK0592446T3 (de)
ES (1) ES2078034T3 (de)
GR (1) GR3017836T3 (de)
WO (1) WO1993000888A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
DE69632859T2 (de) * 1995-04-18 2005-07-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Verfahren zur Arzneistoffbehandlung von Liposomen Zusammensetzung
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
CA2304096C (en) 1997-09-18 2003-09-09 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
NZ504188A (en) 1997-11-14 2001-10-26 Skyepharma Inc Emulsification process for preparing multivesicular liposomes
JP4649841B2 (ja) * 2004-02-18 2011-03-16 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
KR101462819B1 (ko) 2004-05-03 2014-11-21 헤르메스 바이오사이언스, 인코포레이티드 약물 전달에 유용한 리포좀
CA2582949A1 (en) 2004-10-06 2006-04-13 Bc Cancer Agency Liposomes with improved drug retention for treatment of cancer
US20150004219A1 (en) 2012-02-02 2015-01-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Stable liposomes for drug delivery
EP3115039B1 (de) * 2015-07-09 2021-12-15 beniag GmbH Verfahren zum herstellen einer fusionsmischung zur übertragung eines geladenen moleküls in und/oder durch eine lipidmembran
US10456360B2 (en) 2015-10-16 2019-10-29 Ipsen Biopharm Ltd. Stabilizing camptothecin pharmaceutical compositions
CA3070951C (en) 2017-07-24 2023-03-21 Pharmosa Biopharm Inc. Liposome compositions comprising weak acid drugs and uses thereof
US20220018060A1 (en) * 2018-11-15 2022-01-20 The Regents Of The University Of California Vesicle-coated fibers and methods of making and using
NL2023066B1 (en) * 2019-05-03 2020-11-30 Curesupport Holding B V Stabilized liposomes
US12023394B2 (en) * 2020-05-05 2024-07-02 The Regents Of The University Of California Vesicle-coated fibers made from crosslinked lipids
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
DK0478702T3 (da) * 1989-06-22 1995-02-13 Nexstar Pharmaceuticals Inc Indkapslingsproces

Also Published As

Publication number Publication date
JPH06511470A (ja) 1994-12-22
AU9178091A (en) 1993-02-11
AU654835B2 (en) 1994-11-24
ATE128621T1 (de) 1995-10-15
DK0592446T3 (da) 1996-01-29
GR3017836T3 (en) 1996-01-31
WO1993000888A1 (en) 1993-01-21
EP0592446B1 (de) 1995-10-04
ES2078034T3 (es) 1995-12-01
CA2111593A1 (en) 1993-01-21
DE69113640T2 (de) 1996-03-07
EP0592446A1 (de) 1994-04-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEXSTAR PHARMACEUTICALS, INC. (N.D.GES.D.STAATES D

8339 Ceased/non-payment of the annual fee