DK0589322T3 - 5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler. - Google Patents
5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler.Info
- Publication number
- DK0589322T3 DK0589322T3 DK93114676.5T DK93114676T DK0589322T3 DK 0589322 T3 DK0589322 T3 DK 0589322T3 DK 93114676 T DK93114676 T DK 93114676T DK 0589322 T3 DK0589322 T3 DK 0589322T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclohepta
- dienes
- dibenzo
- oxo
- well
- Prior art date
Links
- 230000001177 retroviral effect Effects 0.000 title abstract 2
- HQGYGGZHZWXFSI-UHFFFAOYSA-N 1,4-cycloheptadiene Chemical class C1CC=CCC=C1 HQGYGGZHZWXFSI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polarising Elements (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4232173A DE4232173A1 (de) | 1992-09-25 | 1992-09-25 | 5-Oxo-dibenzo(a,d)cyclohepta-1,4-diene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0589322T3 true DK0589322T3 (da) | 1997-09-22 |
Family
ID=6468847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93114676.5T DK0589322T3 (da) | 1992-09-25 | 1993-09-13 | 5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5457108A (xx) |
| EP (1) | EP0589322B1 (xx) |
| JP (1) | JPH06239827A (xx) |
| KR (1) | KR940006996A (xx) |
| CN (1) | CN1086809A (xx) |
| AT (1) | ATE150450T1 (xx) |
| AU (1) | AU659337B2 (xx) |
| CA (1) | CA2106892A1 (xx) |
| DE (2) | DE4232173A1 (xx) |
| DK (1) | DK0589322T3 (xx) |
| ES (1) | ES2099879T3 (xx) |
| GR (1) | GR3023196T3 (xx) |
| HU (2) | HUT65291A (xx) |
| IL (1) | IL107068A (xx) |
| MX (1) | MX9305773A (xx) |
| NZ (1) | NZ248737A (xx) |
| TW (1) | TW278071B (xx) |
| ZA (1) | ZA937077B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE37781E1 (en) | 1991-10-11 | 2002-07-02 | Dupont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| CA2130754C (en) | 1992-03-11 | 2005-02-08 | Damian W. Grobelny | Amine derivatives of oxo- and hydroxy-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5705524A (en) * | 1994-11-04 | 1998-01-06 | Gilead Sciences, Inc. | Thiepane compounds |
| US6034118A (en) * | 1994-11-04 | 2000-03-07 | Gilead Sciences, Inc. | Thiepane compounds |
| US6169911B1 (en) | 1997-09-26 | 2001-01-02 | Sun Microsystems, Inc. | Graphical user interface for a portable telephone |
| US6313110B1 (en) | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
| DE10238818A1 (de) | 2002-08-23 | 2004-03-04 | Wacker-Chemie Gmbh | Cyclodextrinreste aufweisende Organosiliciumverbindungen |
| WO2015188309A1 (zh) * | 2014-06-10 | 2015-12-17 | 华东理工大学 | 6,7,8,9-四氢-5h-苯并[7]轮烯-2-烷基胺类化合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3401192A (en) * | 1962-07-17 | 1968-09-10 | Merck & Co Inc | Esters of 5h-dibenzo [a, d] cycloheptene |
| US3264342A (en) * | 1963-05-24 | 1966-08-02 | Geigy Chem Corp | Derivatives of 5h-dibenzo[a, d] cycloheptene |
| US3390179A (en) * | 1963-07-22 | 1968-06-25 | Merck & Co Inc | Novel 10, 11-dihydro-10, 11-dihydroxy-(3-substituted aminopropylidene)-5h-dibenzo [a, d] cycloheptenes |
| US3403157A (en) * | 1965-09-01 | 1968-09-24 | American Home Prod | Benzo[6, 7]cyclohepta[1, 2, 3-d, e]isoquinoline derivatives |
| US3436402A (en) * | 1966-03-11 | 1969-04-01 | Lilly Co Eli | 1,1 diaryl-2-propynyl carbamates |
| US3513201A (en) * | 1966-10-25 | 1970-05-19 | Merck & Co Inc | Process for preparing 5-(3-alkylaminopropyl)-5h-dibenzo(a,d)cycloheptenes |
| US3911017A (en) * | 1969-04-04 | 1975-10-07 | Sandoz Ag | 5-Aminomethyl-5H-dibenzo{8 a,d{9 cycloheptenes |
| US3992445A (en) * | 1972-08-25 | 1976-11-16 | Merck & Co., Inc. | 5-Formamidomethyl-5H-dibenzo[a,d]cycloheptene derivatives |
| US4062840A (en) * | 1973-05-02 | 1977-12-13 | Akzona Incorporated | Amino-substituted 1,2,3,4-tetrahydro-9H-tribenzo[b,d,f]azepines |
| US3994961A (en) * | 1973-07-30 | 1976-11-30 | Sandoz, Inc. | 10-(2-Substituted-amino-ethyl)-10,11-dihydro-5-methylene-5H-debenzo[a,d]cycloheptenes |
| US4317910A (en) * | 1978-03-20 | 1982-03-02 | E. R. Squibb & Sons, Inc. | Benzo-cyclitolamines |
| US4596892A (en) * | 1982-08-19 | 1986-06-24 | Fmc Corporation | Methanamine intermediates to insecticidal 2,2'-bridged [1,1'-biphenyl]-3-ylmethyl carboxamides |
-
1992
- 1992-09-25 DE DE4232173A patent/DE4232173A1/de not_active Withdrawn
-
1993
- 1993-08-23 TW TW082106776A patent/TW278071B/zh active
- 1993-08-26 AU AU44930/93A patent/AU659337B2/en not_active Ceased
- 1993-09-13 AT AT93114676T patent/ATE150450T1/de not_active IP Right Cessation
- 1993-09-13 DE DE59305855T patent/DE59305855D1/de not_active Expired - Fee Related
- 1993-09-13 EP EP93114676A patent/EP0589322B1/de not_active Expired - Lifetime
- 1993-09-13 ES ES93114676T patent/ES2099879T3/es not_active Expired - Lifetime
- 1993-09-13 DK DK93114676.5T patent/DK0589322T3/da active
- 1993-09-17 US US08/122,279 patent/US5457108A/en not_active Expired - Fee Related
- 1993-09-21 MX MX9305773A patent/MX9305773A/es unknown
- 1993-09-22 IL IL107068A patent/IL107068A/xx not_active IP Right Cessation
- 1993-09-22 NZ NZ248737A patent/NZ248737A/en unknown
- 1993-09-24 ZA ZA937077A patent/ZA937077B/xx unknown
- 1993-09-24 JP JP5258865A patent/JPH06239827A/ja active Pending
- 1993-09-24 KR KR1019930019575A patent/KR940006996A/ko not_active Application Discontinuation
- 1993-09-24 CA CA002106892A patent/CA2106892A1/en not_active Abandoned
- 1993-09-24 HU HU9302706A patent/HUT65291A/hu unknown
- 1993-09-25 CN CN93117991A patent/CN1086809A/zh active Pending
-
1995
- 1995-06-09 HU HU95P/P00174P patent/HU211175A9/hu unknown
-
1997
- 1997-04-21 GR GR970400857T patent/GR3023196T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW278071B (xx) | 1996-06-11 |
| NZ248737A (en) | 1995-07-26 |
| DE4232173A1 (de) | 1994-03-31 |
| MX9305773A (es) | 1994-05-31 |
| HUT65291A (en) | 1994-05-02 |
| US5457108A (en) | 1995-10-10 |
| JPH06239827A (ja) | 1994-08-30 |
| ZA937077B (en) | 1994-04-18 |
| KR940006996A (ko) | 1994-04-26 |
| CN1086809A (zh) | 1994-05-18 |
| ES2099879T3 (es) | 1997-06-01 |
| HU211175A9 (en) | 1995-11-28 |
| DE59305855D1 (de) | 1997-04-24 |
| CA2106892A1 (en) | 1994-03-26 |
| AU4493093A (en) | 1994-03-31 |
| HU9302706D0 (en) | 1993-12-28 |
| EP0589322B1 (de) | 1997-03-19 |
| AU659337B2 (en) | 1995-05-11 |
| ATE150450T1 (de) | 1997-04-15 |
| GR3023196T3 (en) | 1997-07-30 |
| IL107068A (en) | 1997-07-13 |
| IL107068A0 (en) | 1993-12-28 |
| EP0589322A1 (de) | 1994-03-30 |
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