DK0579804T3 - Biologisk kunstig lever - Google Patents

Biologisk kunstig lever

Info

Publication number
DK0579804T3
DK0579804T3 DK93902996.3T DK93902996T DK0579804T3 DK 0579804 T3 DK0579804 T3 DK 0579804T3 DK 93902996 T DK93902996 T DK 93902996T DK 0579804 T3 DK0579804 T3 DK 0579804T3
Authority
DK
Denmark
Prior art keywords
biologically
artificial liver
containment vessel
perfusion
liver
Prior art date
Application number
DK93902996.3T
Other languages
Danish (da)
English (en)
Inventor
George Edward Barker
Dale Joseph Beck
Albert Pak-Hung Li
Timothy Daniel Whitehead
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DK0579804T3 publication Critical patent/DK0579804T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/12—Glass

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK93902996.3T 1992-02-07 1993-01-06 Biologisk kunstig lever DK0579804T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83246192A 1992-02-07 1992-02-07

Publications (1)

Publication Number Publication Date
DK0579804T3 true DK0579804T3 (da) 1996-08-26

Family

ID=25261723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93902996.3T DK0579804T3 (da) 1992-02-07 1993-01-06 Biologisk kunstig lever

Country Status (12)

Country Link
EP (1) EP0579804B1 (ko)
JP (1) JP3339685B2 (ko)
KR (1) KR100250630B1 (ko)
AT (1) ATE140726T1 (ko)
AU (1) AU661561B2 (ko)
CA (1) CA2107582A1 (ko)
DE (1) DE69303779T2 (ko)
DK (1) DK0579804T3 (ko)
ES (1) ES2090963T3 (ko)
GR (1) GR3020619T3 (ko)
MX (1) MX9300674A (ko)
WO (1) WO1993016171A1 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712154A (en) * 1995-06-07 1998-01-27 W.R. Grace & Co.-Conn. Dual fiber bioreactor
DE19540487A1 (de) * 1995-10-20 1997-04-24 Olaf Schultz Zellinteraktionssystem zur Induktion künstlicher Gewebe
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
AUPP108597A0 (en) * 1997-12-22 1998-01-22 Sheil, A G R Prof. Liver support system
JP4222658B2 (ja) * 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
DE19831873A1 (de) 1998-07-16 2000-03-30 Jens Altrichter Verfahren und Einrichtung zur therapeutischen Immunmodulation
JP2003519503A (ja) * 2000-01-14 2003-06-24 テラクリン アクチエンゲゼルシャフト 物質混合物中の免疫調節活性物質の濃度を増加及び／または減少させる方法及び装置
WO2001070302A1 (fr) * 2000-03-22 2001-09-27 Katsutoshi Naruse Nouveau systeme d'organe artificiel
JP4672511B2 (ja) * 2005-10-05 2011-04-20 学校法人早稲田大学 マイクロ反応装置
GB2467645B (en) * 2007-07-06 2011-12-21 Univ London A method of proliferating human hepatocyte cells
DE102008023545A1 (de) * 2008-05-14 2009-11-19 Roderfeld Und Bora Gmbh & Co.Kg Vorrichtung zur Herstellung einer biologisch aktiven Substanz
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
EP2508607A1 (en) * 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medicament for liver regeneration and for treatment of liver failure
JP2020074698A (ja) * 2018-11-06 2020-05-21 国立大学法人 東京大学 灌流培養システム及び培養方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213404A (en) * 1981-11-13 1986-11-04 Theodore E. Spielberg Ultrafiltering hybrid artificial organ
SU1113131A1 (ru) * 1982-05-31 1984-09-15 Рижский Медицинский Институт Способ лечени печеночной недостаточности
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes

Also Published As

Publication number Publication date
EP0579804A1 (en) 1994-01-26
EP0579804B1 (en) 1996-07-24
WO1993016171A1 (en) 1993-08-19
AU661561B2 (en) 1995-07-27
JPH06509476A (ja) 1994-10-27
CA2107582A1 (en) 1993-08-08
DE69303779T2 (de) 1997-01-16
DE69303779D1 (de) 1996-08-29
KR100250630B1 (ko) 2000-04-01
MX9300674A (es) 1993-10-01
ATE140726T1 (de) 1996-08-15
GR3020619T3 (en) 1996-10-31
JP3339685B2 (ja) 2002-10-28
AU3437393A (en) 1993-09-03
ES2090963T3 (es) 1996-10-16

Similar Documents

Publication Publication Date Title
DK0579804T3 (da) Biologisk kunstig lever
DE69406137D1 (de) Bioreaktor zur biologischen aufbereitung von verschmutztem wasser
DE69621493D1 (de) Hardwareunterstützung zur schnellen Emulation von nicht-implementierten Befehlen
GB1531558A (en) Compositions having affinity for hepatitis virus and method for hepatitis virus removal
ATE150977T1 (de) Markiertes monocyte-chemoattractant- proteinmaterial und medizinische anwendung
DE69108988D1 (de) Vorrichtung zur Erhärtung von Zementmischungen.
NO931189D0 (no) Septiktank omfattende slamsirkulator med gass-supplement
ES2095536T3 (es) Dispersiones acuosas de agentes aglutinantes, endurecibles por radiaciones.
DE69939171D1 (de) Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
EP0558745A4 (en) Sewage purifying device of filter material circulation type
DE69402887D1 (de) Schwimmende Vorrichtung zur Wasserreinigung und Verfahren zur Wasserreinigung
IT1216083B (it) Dispositivo perfezionato perl'esecuzione di esami microbiologici colturali.
ATE78876T1 (de) Verfahren zur behandlung von fluessigen staehlen durch einblasen von gas durch den pfannenboden.
IT9041548A0 (it) Procedimento per la compattazione di materiali di rifiuto urbano, industriale o simili e impianto per l'attuazione del procedimento
ATE160369T1 (de) Fotovernetzbare polyamin-en-zusammensetzungen mit verbesserter härtungsgeschwindigkeit
ATE78463T1 (de) Schwefelhaltige acrylsaeureester und diese enthaltende fungizide.
DE59000992D1 (de) Biofliessbettreaktor mit konditionierungsvorrichtung.
SE8503750L (sv) Anordning for antikorrosionsbehandling och mekanisk forsterkning av komponentelement i undervattenskonstruktioner
DE69104012D1 (de) Rekombiniebares Hepatitis-Delta-Antigen, Verfahren zu seiner Reinigung und Verwendung.
NO975412L (no) Et beholder-arrangement
ATE160096T1 (de) Abwasserbehandlungsreaktor mit düsenboden
DK76292D0 (da) Fremgangsmaade og anlaeg til sikring af tilstedevaerelse af let omsaetteligt carbon ved biologisk spildevandsrensning
Hayward Testing times
IT1225258B (it) Pozzetto prefabbricato in vetroresina rinforzata con elementi prefabbricati in calcestruzzo armato per reti di fognatura
NO913985L (no) Fremgangsmaate og innretning for biologisk avloepsvannbehandling ved hjelp av mikroorganismer