DK0576913T3 - Digitoxigenin og dihydrodigitoxigenin 3 beta-derivater samt farmaceutiske præparater indeholdende sådanne til behandling af hypertension - Google Patents

Digitoxigenin og dihydrodigitoxigenin 3 beta-derivater samt farmaceutiske præparater indeholdende sådanne til behandling af hypertension

Info

Publication number
DK0576913T3
DK0576913T3 DK93109610.1T DK93109610T DK0576913T3 DK 0576913 T3 DK0576913 T3 DK 0576913T3 DK 93109610 T DK93109610 T DK 93109610T DK 0576913 T3 DK0576913 T3 DK 0576913T3
Authority
DK
Denmark
Prior art keywords
dihydrodigitoxigenin
digitoxigenin
hypertension
treatment
pharmaceutical compositions
Prior art date
Application number
DK93109610.1T
Other languages
Danish (da)
English (en)
Inventor
Piero Melloni
Luigi Bernardi
Patrizia Ferrari
Mauro Gobbini
Marco Torri
Loredana Valentino
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0576913T3 publication Critical patent/DK0576913T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
DK93109610.1T 1992-07-01 1993-06-16 Digitoxigenin og dihydrodigitoxigenin 3 beta-derivater samt farmaceutiske præparater indeholdende sådanne til behandling af hypertension DK0576913T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4221635A DE4221635C1 (de) 1992-07-01 1992-07-01 3beta-Digitoxigenin- und 3beta-Dihydrodigitoxigenin-Derivate

Publications (1)

Publication Number Publication Date
DK0576913T3 true DK0576913T3 (da) 1997-11-03

Family

ID=6462264

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93109610.1T DK0576913T3 (da) 1992-07-01 1993-06-16 Digitoxigenin og dihydrodigitoxigenin 3 beta-derivater samt farmaceutiske præparater indeholdende sådanne til behandling af hypertension

Country Status (8)

Country Link
US (1) US5478817A (de)
EP (1) EP0576913B1 (de)
JP (1) JPH0665285A (de)
AT (1) ATE157670T1 (de)
DE (2) DE4221635C1 (de)
DK (1) DK0576913T3 (de)
ES (1) ES2106922T3 (de)
GR (1) GR3024707T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361478B2 (en) * 2001-11-20 2008-04-22 Allergan, Inc. High-throughput screen for identifying selective persistent sodium channels channel blockers
US20040064050A1 (en) * 2002-09-20 2004-04-01 Jun Liu System and method for screening tissue

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2004543A1 (de) * 1970-02-02 1971-08-12 Knoll Ag, Chemische Fabriken, 6700 Ludwigshafen Alkoxymethylather von herzwirksamen Steroiden
DE2517293C2 (de) * 1975-04-18 1984-02-16 Knoll Ag, 6700 Ludwigshafen Neue Cardenolid-β-Glykoside, ihre Herstellung und Verwendung
FR2310766A1 (fr) * 1975-05-16 1976-12-10 Nativelle Sa Ets Derives de cardenolides, procede de preparation et application a titre de medicament
DE2833472A1 (de) * 1978-07-29 1980-03-06 Beiersdorf Ag Digitoxigenin-monodigitoxosid-derivate und verfahren zu ihrer herstellung
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8916635D0 (en) * 1989-07-20 1989-09-06 Erba Carlo Spa Cardanolactam derivatives

Also Published As

Publication number Publication date
EP0576913B1 (de) 1997-09-03
ATE157670T1 (de) 1997-09-15
GR3024707T3 (en) 1997-12-31
DE69313534D1 (de) 1997-10-09
EP0576913A3 (de) 1995-04-19
DE69313534T2 (de) 1998-02-19
DE4221635C1 (de) 1994-05-05
EP0576913A2 (de) 1994-01-05
US5478817A (en) 1995-12-26
ES2106922T3 (es) 1997-11-16
JPH0665285A (ja) 1994-03-08

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