DK0539442T3 - Enzyminaktivatorer - Google Patents

Enzyminaktivatorer

Info

Publication number
DK0539442T3
DK0539442T3 DK91913059T DK91913059T DK0539442T3 DK 0539442 T3 DK0539442 T3 DK 0539442T3 DK 91913059 T DK91913059 T DK 91913059T DK 91913059 T DK91913059 T DK 91913059T DK 0539442 T3 DK0539442 T3 DK 0539442T3
Authority
DK
Denmark
Prior art keywords
uracil
substituted
enzyme activators
group
halogen
Prior art date
Application number
DK91913059T
Other languages
English (en)
Inventor
Saad George Rahim
Thomas Spector
David John Timothy Porter
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909015896A external-priority patent/GB9015896D0/en
Priority claimed from GB909025039A external-priority patent/GB9025039D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0539442T3 publication Critical patent/DK0539442T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK91913059T 1990-07-19 1991-07-18 Enzyminaktivatorer DK0539442T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909015896A GB9015896D0 (en) 1990-07-19 1990-07-19 Enzyme inactivators
GB909025039A GB9025039D0 (en) 1990-11-17 1990-11-17 Enzyme inactivators
PCT/GB1991/001197 WO1992001452A1 (en) 1990-07-19 1991-07-18 Enzyme inactivators

Publications (1)

Publication Number Publication Date
DK0539442T3 true DK0539442T3 (da) 1998-09-07

Family

ID=26297354

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91913059T DK0539442T3 (da) 1990-07-19 1991-07-18 Enzyminaktivatorer

Country Status (12)

Country Link
US (3) US6177436B1 (da)
EP (2) EP0539442B1 (da)
JP (2) JP3094036B2 (da)
AT (1) ATE161722T1 (da)
CY (1) CY2130B1 (da)
DE (1) DE69128626T2 (da)
DK (1) DK0539442T3 (da)
ES (1) ES2111569T3 (da)
GR (1) GR3026487T3 (da)
HK (1) HK1004324A1 (da)
SG (1) SG49855A1 (da)
WO (1) WO1992001452A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
CA2103050A1 (en) * 1991-05-15 1992-11-16 Yung-Chi Cheng Determination of prodrugs metabolizable by the liver and therapeutic use thereof
GB9322795D0 (en) * 1993-11-05 1993-12-22 Wellcome Found Novel compounds
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives
AU2002360697B2 (en) * 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
CN101068549A (zh) * 2004-12-03 2007-11-07 阿迪赫里克斯技术公司 与5-fu和5-fu前药组合施用dpd抑制剂的方法
JP4910294B2 (ja) * 2005-02-17 2012-04-04 大日本印刷株式会社 カラーフィルタ基板および液晶表示パネル
GB0608876D0 (en) * 2006-05-05 2006-06-14 Medivir Ab Combination therapy
EA201270551A1 (ru) * 2009-10-14 2012-12-28 Эдхиэрекс Текнолоджиз, Инк. Лечение нейротоксичности, ассоциированной с комбинациями 5-fu или его пролекарств с ингибиторами dpd

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124765A (en) 1975-05-13 1978-11-07 Ono Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
DE2522369A1 (de) * 1975-05-21 1976-12-02 Ono Pharmaceutical Co 5-fluoruracilderivate und verfahren zu ihrer herstellung
US4381344A (en) 1980-04-25 1983-04-26 Burroughs Wellcome Co. Process for producing deoxyribosides using bacterial phosphorylase
US4719214A (en) * 1985-07-25 1988-01-12 Southern Research Institute Carbocyclic analogues of thymine nucleosides
GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
US4874602A (en) * 1988-02-22 1989-10-17 Paul Calabresi Reduction of the severity 3'-azido-3'-deoxythymidine-induced anemia using benzylacyclouridine
ZA892407B (en) * 1988-03-31 1989-11-29 Mitsubishi Chem Ind 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof
NL8800942A (nl) 1988-04-12 1989-11-01 Lely Nv C Van Der Landbouwmachine.
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5643913A (en) 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds

Also Published As

Publication number Publication date
GR3026487T3 (en) 1998-07-31
CY2130B1 (en) 2002-06-21
ATE161722T1 (de) 1998-01-15
JP3094036B2 (ja) 2000-10-03
JP3359319B2 (ja) 2002-12-24
EP0539442A1 (en) 1993-05-05
JP2000297076A (ja) 2000-10-24
EP0539442B1 (en) 1998-01-07
DE69128626D1 (de) 1998-02-12
DE69128626T2 (de) 1998-05-20
US6177436B1 (en) 2001-01-23
ES2111569T3 (es) 1998-03-16
SG49855A1 (en) 1998-06-15
WO1992001452A1 (en) 1992-02-06
EP0711555A2 (en) 1996-05-15
US6586440B2 (en) 2003-07-01
HK1004324A1 (en) 1998-11-20
JPH06502619A (ja) 1994-03-24
US6221852B1 (en) 2001-04-24
EP0711555A3 (da) 1996-06-26
US20010025033A1 (en) 2001-09-27

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