DK0525132T3 - Binding af genkendende stoffer til liposomer - Google Patents

Binding af genkendende stoffer til liposomer

Info

Publication number
DK0525132T3
DK0525132T3 DK92900243.4T DK92900243T DK0525132T3 DK 0525132 T3 DK0525132 T3 DK 0525132T3 DK 92900243 T DK92900243 T DK 92900243T DK 0525132 T3 DK0525132 T3 DK 0525132T3
Authority
DK
Denmark
Prior art keywords
liposomes
recognizing substances
crosslinking reagents
recognizing
methodologies
Prior art date
Application number
DK92900243.4T
Other languages
Danish (da)
English (en)
Inventor
Rimona Margalit
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Application granted granted Critical
Publication of DK0525132T3 publication Critical patent/DK0525132T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK92900243.4T 1991-02-14 1991-10-30 Binding af genkendende stoffer til liposomer DK0525132T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65587891A 1991-02-14 1991-02-14

Publications (1)

Publication Number Publication Date
DK0525132T3 true DK0525132T3 (da) 1996-02-05

Family

ID=24630761

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92900243.4T DK0525132T3 (da) 1991-02-14 1991-10-30 Binding af genkendende stoffer til liposomer

Country Status (10)

Country Link
US (1) US5401511A (fr)
EP (1) EP0525132B1 (fr)
JP (1) JP3407072B2 (fr)
AT (1) ATE132367T1 (fr)
AU (1) AU651414B2 (fr)
CA (1) CA2079444C (fr)
DE (1) DE69116144T2 (fr)
DK (1) DK0525132T3 (fr)
ES (1) ES2084335T3 (fr)
WO (1) WO1992014447A1 (fr)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
GB9208339D0 (en) * 1992-04-15 1992-06-03 Unilever Plc Treatment composition
US5654000A (en) * 1992-07-28 1997-08-05 Poli Industria Chimica S.P.A. Pharmaceutical compositions for transmucosal delivery of peptides
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
CA2140053C (fr) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Systeme a base de collagene pour l'administration de drogue injectable, et utilisation
US5658588A (en) * 1995-03-31 1997-08-19 University Of Cincinnati Fibrinogen-coated liposomes
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
EP0963196B1 (fr) * 1996-09-27 2005-01-19 Jagotec Ag Systeme hyaluronique d'administration de medicaments
DE19852928C1 (de) * 1998-11-17 2000-08-03 Steffen Panzner Strukturen in Form von Hohlkugeln
EP1754488A1 (fr) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Methodes et compositions de thérapie génique non-virale pour le traitement des maladies hyperprolifératives
US8076312B2 (en) 2000-01-10 2011-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Use of lipid conjugates in the treatment of disease
US7811999B2 (en) 2000-01-10 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US8304395B2 (en) * 2000-01-10 2012-11-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid conjugates in the treatment of disease
US8501701B2 (en) * 2000-01-10 2013-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US7608598B2 (en) 2000-01-10 2009-10-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of conjunctivitis
US7772196B2 (en) 2000-01-10 2010-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US9040078B2 (en) * 2000-01-10 2015-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases of the nervous system
US20060189568A1 (en) * 2000-01-10 2006-08-24 Saul Yedgar Use of lipid conjugates in the treatment of infection
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US7893226B2 (en) 2004-09-29 2011-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US7393938B2 (en) * 2000-01-10 2008-07-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US20090325876A1 (en) * 2004-09-29 2009-12-31 Saul Yedgar Use of lipid conjugates in the treatment of diseases associated with vasculature
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
WO2002020724A2 (fr) 2000-09-08 2002-03-14 Board Of Regents, The University Of Texas System Ciblage adénoviral et manipulation de la réponse du système immunitaire au moyen de peptides ciblants
US8883761B2 (en) * 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
JP2004536614A (ja) * 2001-08-01 2004-12-09 ユニバーシティ オブ ユタ Pde3環状ヌクレオチド・ホスホジエステラーゼのアイソフォーム選択的な阻害剤および活性化剤
JP4537057B2 (ja) * 2001-08-14 2010-09-01 テルアビブ・ユニバーシティ・フューチャー・テクノロジー・デベロップメント・エルピー 脂質化グリコサミノグリカン粒子ならびに診断及び処置のための薬物及び遺伝子送達におけるその使用
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
US8728510B1 (en) 2002-03-15 2014-05-20 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing a bioadhesive material
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
US20040110208A1 (en) * 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
WO2004038037A2 (fr) * 2002-09-20 2004-05-06 Intel Corporation Alignement oriente de codes a barre nanometriques codant une information specifique pour la lecture par microscopie electronique a balayage (spm)
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
US7270952B2 (en) * 2002-09-24 2007-09-18 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
WO2004029625A2 (fr) * 2002-09-24 2004-04-08 Intel Corporation Detection de liaison moleculaire par surveillance de deviations de montage en porte-a-faux commande par reaction
WO2004053051A2 (fr) 2002-12-11 2004-06-24 Ferrosan A/S Tampons a prelevements a base de gelatine
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
JP2007502833A (ja) * 2003-08-21 2007-02-15 サウスウエスト・リサーチ・インスティチュート 骨格に標的とされるナノ粒子
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
US20050147976A1 (en) * 2003-12-29 2005-07-07 Xing Su Methods for determining nucleotide sequence information
US20050147964A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods for identifying a peptide that binds a geometrical shape
US20050147979A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US9062392B2 (en) 2003-12-30 2015-06-23 Intel Corporation Methods for isolating a peptide methods for identifying a peptide
EP1713521B1 (fr) * 2004-01-30 2010-07-28 Ferrosan A/S Pulverisations et compositions hemostatiques
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
FR2870741B1 (fr) * 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
KR20070046093A (ko) * 2004-07-09 2007-05-02 훼로산 아크티에 셀스카브 히알루론산을 포함하는 지혈 조성물
US8808664B2 (en) * 2004-07-13 2014-08-19 Ramot At Tel-Aviv University Ltd. Lipidated glycoprotein particles and methods of use
US7709247B2 (en) * 2004-08-04 2010-05-04 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation
US20060210549A1 (en) * 2004-09-10 2006-09-21 Srivastava Devendra K Controlled release liposomes and methods of use
WO2006050246A2 (fr) 2004-11-02 2006-05-11 Tel-Aviv University Future Technology Development L.P. Formulations de medicaments insolubles dans l'eau ou faiblement solubles dans l'eau dans des particules de glycosaminoglycane lipides et leur utilisation dans des diagnostics et une therapie
WO2007019131A2 (fr) * 2005-08-03 2007-02-15 Morria Biopharmaceuticals Utilisation de conjugues lipides en cas de fibrose cystique et applications correspondantes
US20070077292A1 (en) * 2005-10-03 2007-04-05 Pinsky Mark A Compositions and methods for improved skin care
US8906882B2 (en) 2005-11-17 2014-12-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of allergic rhinitis
US8859524B2 (en) 2005-11-17 2014-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of chronic rhinosinusitis
PT1962805T (pt) 2005-12-08 2016-10-05 Insmed Inc Composições de anti-infeciosos baseadas em lípidos para tratamento de infeções pulmonares
WO2007092944A2 (fr) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions et procedes impliquant une therapie de gene et une modulation de proteasome
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
AU2007243370A1 (en) * 2006-04-24 2007-11-08 The Cbr Institute For Biomedical Research, Inc. Method of producing immunoliposomes and compositions thereof
US7951776B2 (en) 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
CA2705785A1 (fr) * 2006-11-14 2008-05-22 Saul Yedgar Utilisation de conjugues lipidiques dans le traitement de maladies ou de troubles oculaires
US20080113002A1 (en) * 2006-11-14 2008-05-15 Saul Yedgar Contact lens compositions
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
EP2283028A2 (fr) 2007-08-08 2011-02-16 The Board of Regents of The University of Texas System Peptides ciblant vegfr-1/nrp-1
WO2009108554A2 (fr) 2008-02-27 2009-09-03 Ramot At Tel Aviv University Ltd. Système d’administration de protéine sous forme de fibrilles ou d’agrégats insolubles
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
US9371386B2 (en) 2009-03-16 2016-06-21 Daniel A. Vallera Methods and compositions for bi-specific targeting of CD19/CD22
JP2012526819A (ja) 2009-05-11 2012-11-01 イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム リミテッド 脂質−ポリマー複合体、その調製、及びその使用
GB0913442D0 (en) 2009-07-31 2009-09-16 Univ Ramot Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
US20120269721A1 (en) * 2009-10-12 2012-10-25 The Regents Of The University Of California Targeted nanoclusters and methods of their use
JP2014519493A (ja) * 2011-05-12 2014-08-14 イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッド ポリマー共役脂質を含むリポソームおよび関連用途
RU2657955C2 (ru) 2012-03-06 2018-06-18 Ферросан Медикал Дивайсиз А/С Контейнер под давлением, содержащий гемостатическую пасту
JP2015514746A (ja) 2012-04-18 2015-05-21 ラモット アット テル アビブ ユニバーシティ, リミテッド 核酸を送達するための脂質化グリコサミノグリカン粒子
EP2825216B1 (fr) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Composition hémostatique sèche
MX2015006681A (es) 2012-11-29 2016-04-06 Insmed Inc Formulaciones de vancomicina estabilizadas.
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー/エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
AU2014340568B2 (en) 2013-10-22 2017-02-02 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
WO2015175939A1 (fr) 2014-05-15 2015-11-19 Insmed Incorporated Méthodes de traitement d'infections pulmonaires mycobactériennes non-tuberculeuses
EP3160448A4 (fr) 2014-06-26 2018-11-14 Ramot at Tel-Aviv University Ltd. Formulations de liposome pour l'administration d'acides nucléiques
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
WO2016102446A1 (fr) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Seringue pour retenir et mélanger des première et seconde substances
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
EP3773505A4 (fr) 2018-03-30 2021-12-22 Insmed Incorporated Procédés pour la fabrication continue de produits médicamenteux liposomaux
JP7197106B2 (ja) * 2018-04-27 2022-12-27 国立大学法人北海道大学 脂質ナノ粒子
CA3097819A1 (fr) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Procede de preparation d'une composition hemostatique

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS59210013A (ja) * 1983-05-04 1984-11-28 Ajinomoto Co Inc 活性物質含有リポソ−ム
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US4761288A (en) * 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
EP0211042A1 (fr) * 1985-01-18 1987-02-25 Cooper-Lipotech, Inc. Composition liposomique
FR2597345B1 (fr) * 1986-04-22 1990-08-03 Oreal Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques.
WO1988000824A1 (fr) * 1986-07-28 1988-02-11 Liposome Technology, Inc. Liposomes a retention amelioree sur du tissu muqueux
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
EP0366770B1 (fr) * 1988-05-16 1994-02-09 Vestar, Inc. Liposomes accouples a des hormones
EP0397542B1 (fr) * 1988-12-02 1992-07-15 Coletica Stabilisation de phases lamellaires hydratées
FR2645741B1 (fr) * 1989-03-20 1995-06-23 Dior Christian Parfums Procede pour fixer un produit sur la membrane d'un keratinocyte au moyen d'une liaison ligand-recepteur, procede de preparation d'un tel produit, produit obtenu, composition cosmetique ou pharmaceutique le contenant et son procede de preparation
AU652778B2 (en) * 1990-10-15 1994-09-08 Quest International B.V. Treatment composition
PL296382A1 (en) * 1991-02-02 1993-11-02 Nika Health Products Ltd Li Li Artificial membrane beads containing functionally active peptides responsible for fusion as a drug administering system

Also Published As

Publication number Publication date
CA2079444A1 (fr) 1992-08-15
DE69116144T2 (de) 1996-05-09
EP0525132A1 (fr) 1993-02-03
JP3407072B2 (ja) 2003-05-19
ATE132367T1 (de) 1996-01-15
AU9037091A (en) 1992-09-15
JPH05505827A (ja) 1993-08-26
ES2084335T3 (es) 1996-05-01
CA2079444C (fr) 2004-02-03
US5401511A (en) 1995-03-28
EP0525132B1 (fr) 1996-01-03
WO1992014447A1 (fr) 1992-09-03
AU651414B2 (en) 1994-07-21
DE69116144D1 (de) 1996-02-15

Similar Documents

Publication Publication Date Title
DK0525132T3 (da) Binding af genkendende stoffer til liposomer
FI945912A (fi) Proteinoidikantajat ja menetelmät niiden valmistamiseksi sekä niiden käyttö
DK0750494T3 (da) Hydrofobe lægemiddelafgivelsessystemer
SE9502168L (sv) Insulinanalog-kompositioner
AU6985691A (en) Pharmaceutical and cosmetic compositions
FI941777A0 (fi) Vesipitoinen farmaseuttinen suspensio ja menetelmä sen valmistamiseksi
DE59309257D1 (de) Verfahren zur herstellung von mikrokapseln
AU6950596A (en) Laser assisted drug delivery
ES2171710T3 (es) Emplastos con hormonas.
ATE288719T1 (de) Kontrollierte abgabe von pharmazeutika in der vorderen augenkammer
NO2004004I2 (no) Bortezomib eller en farmasøytisk akseptabel ester derav, eventuelt i form av et farmasøytisk akseptabelt salt derav
FR2740686B1 (fr) Formulation pharmaceutique lyophilisee stable
MX9709028A (es) Suministro de aciclovir oral.
EP1308553A3 (fr) Produits fibreux fonctionnels et procédé pour leur préparation
AU8091091A (en) Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
AU647518B2 (en) Coating base for pharmaceutical film and production thereof
DE69840150D1 (de) Verfahren, basierend auf affinitätskreuzbindung, der interaktion von biologisch aktiven peptiden an antikörper
AU5816496A (en) Process for the depyrogenation of injectable pharmaceutical solutions
IT8948112A0 (it) Proiettile esente da angolo di imbardata
DE69315730T2 (de) Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
ITTO930519A0 (it) Procedimento di sintesi di acidi cloroacetici.
AU1195697A (en) 2-pyrazolyl oxyphenyl acetic acid derivatives, agents containing them and their use for combatting damaging fungi and animal pests
IT1230167B (it) Procedimento per il rivestimento con pellicola di composizioni farmaceutiche con dispersioni di polimeri.
BR9813102A (pt) Derivados de ácido metilenobisfosfÈnico novos
AU1166997A (en) Trans apovincaminic acid ester derivatives as drugs