DK0474672T3 - Hidtil ukendt forbindelsesklasse med et variabelt aktivitetsspektrum af capsaicinlignende responser, præparater og anvendelser deraf - Google Patents
Hidtil ukendt forbindelsesklasse med et variabelt aktivitetsspektrum af capsaicinlignende responser, præparater og anvendelser derafInfo
- Publication number
- DK0474672T3 DK0474672T3 DK90907806.5T DK90907806T DK0474672T3 DK 0474672 T3 DK0474672 T3 DK 0474672T3 DK 90907806 T DK90907806 T DK 90907806T DK 0474672 T3 DK0474672 T3 DK 0474672T3
- Authority
- DK
- Denmark
- Prior art keywords
- capsaicin
- responses
- preparations
- activity
- applications
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000001228 spectrum Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- QGVLYPPODPLXMB-UBTYZVCOSA-N (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one Chemical compound C1=C(CO)C[C@]2(O)C(=O)C(C)=C[C@H]2[C@@]2(O)[C@H](C)[C@@H](O)[C@@]3(O)C(C)(C)[C@H]3[C@@H]21 QGVLYPPODPLXMB-UBTYZVCOSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229930004069 diterpene Natural products 0.000 abstract 1
- 150000004141 diterpene derivatives Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QGVLYPPODPLXMB-QXYKVGAMSA-N phorbol Natural products C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@H]3C=C(CO)C[C@@]4(O)[C@H](C=C(C)C4=O)[C@@]13O)C2(C)C QGVLYPPODPLXMB-QXYKVGAMSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/86—Ring systems containing bridged rings containing four rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/358,073 US5021450A (en) | 1989-05-30 | 1989-05-30 | New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0474672T3 true DK0474672T3 (da) | 1996-10-28 |
Family
ID=23408188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90907806.5T DK0474672T3 (da) | 1989-05-30 | 1990-03-30 | Hidtil ukendt forbindelsesklasse med et variabelt aktivitetsspektrum af capsaicinlignende responser, præparater og anvendelser deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5021450A (da) |
| EP (1) | EP0474672B1 (da) |
| JP (2) | JP2694479B2 (da) |
| AT (1) | ATE141585T1 (da) |
| AU (1) | AU644363B2 (da) |
| CA (1) | CA2057917C (da) |
| DE (1) | DE69028203T2 (da) |
| DK (1) | DK0474672T3 (da) |
| ES (1) | ES2093645T3 (da) |
| WO (1) | WO1990015055A1 (da) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5232684A (en) * | 1990-06-29 | 1993-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Labelled resiniferatoxin, compositions thereof, and methods for using the same |
| US5405875A (en) * | 1991-04-08 | 1995-04-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method of inhibiting neoplasia and tumor promotion |
| US6063381A (en) * | 1993-05-19 | 2000-05-16 | Staggs; Jeff J. | Therapeutic uses of pungent botanicals and their related compounds |
| CA2264739C (en) * | 1996-09-05 | 2008-03-18 | Research Development Foundation | Inhibition of nuclear transcription factor nf-kb by caffeic acid phenethyl ester (cape), derivatives of cape, capsaicin (8-methyl-n-vanillyl-6-nonenamide) and resiniferatoxin |
| WO1998020867A1 (en) * | 1996-11-15 | 1998-05-22 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists |
| US6060060A (en) * | 1997-01-31 | 2000-05-09 | Bmb Patent Holding Corporation | Analgesic compositions from sweet peppers and methods of use thereof |
| WO1999009970A1 (en) * | 1997-08-28 | 1999-03-04 | Afferon Corporation | Urinary incontinence therapy |
| WO1999037675A1 (en) * | 1998-01-22 | 1999-07-29 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptors |
| US6790207B2 (en) * | 1998-06-04 | 2004-09-14 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract |
| US6802841B2 (en) | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| US20110071468A1 (en) * | 1998-06-04 | 2011-03-24 | Mederi Therapeutics, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| US6086888A (en) * | 1998-12-22 | 2000-07-11 | Bmb Patent Holding Corporation | Analgesic compositions from sweet bell peppers and methods of use thereof |
| WO2000050387A1 (en) * | 1999-02-22 | 2000-08-31 | Pacific Corporation | Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof |
| KR100348819B1 (ko) * | 1999-02-22 | 2002-08-17 | 주식회사 태평양 | 레시니페라톡신 약리기를 함유하여 강력한 바닐로이드수용체의 효현제 및 진통제로서 사용하는 바닐로이드동족체 및 이를 함유하는 약학적 조성물 |
| AU8066701A (en) * | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| RS63204A (sr) * | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
| US20040161481A1 (en) * | 2002-12-18 | 2004-08-19 | Algorx | Administration of capsaicinoids |
| AU2003299691B2 (en) | 2002-12-18 | 2008-06-05 | Algorx Pharmaceuticals, Inc. | Administration of capsaicinoids |
| US20050085652A1 (en) * | 2003-04-08 | 2005-04-21 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
| WO2006058140A2 (en) * | 2004-11-24 | 2006-06-01 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
| EP1924548B1 (en) | 2005-07-13 | 2018-03-28 | Salvia Sciences, Inc. | Ester prodrugs of prostratin and related phorbol compounds |
| US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
| US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| EP2096927B1 (en) | 2006-10-27 | 2012-10-10 | BMB Patent Holding Corporation | Therapeutic compositions and methods of treatment with capsianoside-type compounds |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
| US8987328B2 (en) * | 2008-10-30 | 2015-03-24 | Trinity Laboratories, Inc. | Esters of capsaicinoids as dietary supplements |
| US8980223B2 (en) * | 2009-05-07 | 2015-03-17 | University Of Cincinnati | Methods of preventing ischemic injury using peripheral nociceptive stimulation |
| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
| MX2019001455A (es) | 2016-08-04 | 2019-06-20 | Takasago Perfumery Co Ltd | Compuestos de sensacion de calor. |
| EP3534961B1 (en) | 2016-11-02 | 2026-02-11 | Centrexion Therapeutics Corporation | Stable aqueous capsaicin injectable formulations and medical uses thereof |
| WO2019018769A1 (en) | 2017-07-20 | 2019-01-24 | Centrexion Therapeutics Corporation | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE |
| MX2020002692A (es) | 2017-09-11 | 2020-10-14 | Sorrento Therapeutics Inc | Formulacion de resiniferatoxina. |
| KR20210107086A (ko) | 2018-12-24 | 2021-08-31 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 레시니페라톡신의 투여에 의한 파킨슨병의 치료 방법 |
| EP3914595A4 (en) | 2019-01-22 | 2022-11-09 | Sorrento Therapeutics, Inc. | METHOD OF TREATMENT OF OSTEOARTHRITIS PAIN BY ADMINISTRATION OF RESINIFERATOXIN |
| CN111312928A (zh) * | 2020-03-12 | 2020-06-19 | 昆明理工大学 | 一种热诱导改变带隙的半导体器件 |
| CA3173611A1 (en) | 2020-03-30 | 2021-10-07 | Alexis Nahama | Treating pulmonary inflammatory disease associated with covid-19 by administering resiniferatoxin |
| TW202214229A (zh) | 2020-06-19 | 2022-04-16 | 美商索倫多醫療公司 | 投與樹脂毒素(Resiniferatoxin)以治療膀胱痛或膀胱癌 |
| WO2022173916A1 (en) | 2021-02-11 | 2022-08-18 | Sorrento Therapeutics, Inc. | Administration of resiniferatoxin for treatment of prostate cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2902506A1 (de) * | 1979-01-23 | 1980-07-24 | Deutsches Krebsforsch | Verwendung von nicht oder nur gering irritierenden und/oder promovierenden diterpenalkoholen und von derivaten davon als antineoplastische mittel |
| US4939149A (en) * | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
-
1989
- 1989-05-30 US US07/358,073 patent/US5021450A/en not_active Expired - Lifetime
-
1990
- 1990-03-30 CA CA002057917A patent/CA2057917C/en not_active Expired - Fee Related
- 1990-03-30 EP EP90907806A patent/EP0474672B1/en not_active Expired - Lifetime
- 1990-03-30 DK DK90907806.5T patent/DK0474672T3/da active
- 1990-03-30 WO PCT/US1990/001767 patent/WO1990015055A1/en not_active Ceased
- 1990-03-30 ES ES90907806T patent/ES2093645T3/es not_active Expired - Lifetime
- 1990-03-30 AT AT90907806T patent/ATE141585T1/de not_active IP Right Cessation
- 1990-03-30 DE DE69028203T patent/DE69028203T2/de not_active Expired - Fee Related
- 1990-03-30 JP JP2507063A patent/JP2694479B2/ja not_active Expired - Fee Related
- 1990-03-30 AU AU55614/90A patent/AU644363B2/en not_active Ceased
-
1996
- 1996-07-09 JP JP8198456A patent/JP3028290B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0474672A1 (en) | 1992-03-18 |
| JPH04503360A (ja) | 1992-06-18 |
| AU5561490A (en) | 1991-01-07 |
| DE69028203D1 (de) | 1996-09-26 |
| ATE141585T1 (de) | 1996-09-15 |
| AU644363B2 (en) | 1993-12-09 |
| DE69028203T2 (de) | 1997-03-06 |
| CA2057917A1 (en) | 1990-12-01 |
| JP3028290B2 (ja) | 2000-04-04 |
| EP0474672A4 (en) | 1992-06-17 |
| WO1990015055A1 (en) | 1990-12-13 |
| ES2093645T3 (es) | 1997-01-01 |
| JPH09165333A (ja) | 1997-06-24 |
| EP0474672B1 (en) | 1996-08-21 |
| JP2694479B2 (ja) | 1997-12-24 |
| CA2057917C (en) | 2001-12-18 |
| US5021450A (en) | 1991-06-04 |
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