DK0460065T3 - Fremgangsmåde til at fremkalde formering af CD4-lymfocytter - Google Patents
Fremgangsmåde til at fremkalde formering af CD4-lymfocytterInfo
- Publication number
- DK0460065T3 DK0460065T3 DK90904107.1T DK90904107T DK0460065T3 DK 0460065 T3 DK0460065 T3 DK 0460065T3 DK 90904107 T DK90904107 T DK 90904107T DK 0460065 T3 DK0460065 T3 DK 0460065T3
- Authority
- DK
- Denmark
- Prior art keywords
- lymphocytes
- inducing
- methyl ester
- leucine methyl
- alkyl ester
- Prior art date
Links
- 210000004698 lymphocyte Anatomy 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title 1
- 230000035755 proliferation Effects 0.000 title 1
- AJMOLNFDYWTVQW-QWRGUYRKSA-N L-leucyl-l-leucine methyl ester Chemical compound COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C AJMOLNFDYWTVQW-QWRGUYRKSA-N 0.000 abstract 2
- 108010062054 leucyl-leucine-methyl ester Proteins 0.000 abstract 2
- QVDXUKJJGUSGLS-LURJTMIESA-N methyl L-leucinate Chemical compound COC(=O)[C@@H](N)CC(C)C QVDXUKJJGUSGLS-LURJTMIESA-N 0.000 abstract 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 229940122760 T cell stimulant Drugs 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31342189A | 1989-02-21 | 1989-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0460065T3 true DK0460065T3 (da) | 1994-09-26 |
Family
ID=23215624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90904107.1T DK0460065T3 (da) | 1989-02-21 | 1990-02-08 | Fremgangsmåde til at fremkalde formering af CD4-lymfocytter |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0460065B1 (de) |
AT (1) | ATE110770T1 (de) |
AU (1) | AU645488B2 (de) |
DE (1) | DE69012105T2 (de) |
DK (1) | DK0460065T3 (de) |
HU (1) | HU902289D0 (de) |
WO (1) | WO1990010059A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE68836B1 (en) * | 1991-01-16 | 1996-07-10 | Schering Corp | Use of interleukin-10 in adoptive immunotherapy of cancer |
US5374549A (en) * | 1991-01-31 | 1994-12-20 | Terumo Corporation | Process of enriching adherent CD4+ T cells from monocyte depleted peripheral blood mononuclear cells with interleukin 2 and interleukin 4 |
DE4410136A1 (de) * | 1993-03-31 | 1994-10-06 | Boehringer Mannheim Gmbh | Tumorizide T-Lymphozyten |
US5834441A (en) * | 1993-09-13 | 1998-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Adeno-associated viral (AAV) liposomes and methods related thereto |
US6652850B1 (en) | 1993-09-13 | 2003-11-25 | Aventis Pharmaceuticals Inc. | Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity |
EP0797450A4 (de) * | 1994-12-01 | 2000-02-02 | New England Deaconess Hospital | In vitro t-lymphopoiese system |
CN107502589A (zh) * | 2017-08-04 | 2017-12-22 | 北京世纪劲得生物技术有限公司 | 一种肿瘤浸润淋巴细胞与单个核细胞共培养方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4849329A (en) * | 1986-05-30 | 1989-07-18 | E. I. Du Pont De Nemours And Company | Process for preparing lymphokine activated killer cells |
SE459008B (sv) * | 1986-09-04 | 1989-05-29 | Bioinvent Int Ab | Saett att framsstaella humana monoklonala antikroppar |
CA1300058C (en) * | 1987-01-29 | 1992-05-05 | Joseph D. Irr | Process for preparing activated killer cells |
US4808151A (en) * | 1987-04-27 | 1989-02-28 | E. I. Du Pont De Nemours And Company | Simplified method for the preparation of human lymphokine activated killer cells |
SE461985B (sv) * | 1988-09-13 | 1990-04-23 | Bioinvent Int Ab | In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer |
-
1990
- 1990-02-08 WO PCT/US1990/000611 patent/WO1990010059A1/en active IP Right Grant
- 1990-02-08 AU AU51965/90A patent/AU645488B2/en not_active Ceased
- 1990-02-08 HU HU902289A patent/HU902289D0/hu unknown
- 1990-02-08 AT AT90904107T patent/ATE110770T1/de not_active IP Right Cessation
- 1990-02-08 DK DK90904107.1T patent/DK0460065T3/da active
- 1990-02-08 EP EP90904107A patent/EP0460065B1/de not_active Expired - Lifetime
- 1990-02-08 DE DE69012105T patent/DE69012105T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0460065B1 (de) | 1994-08-31 |
WO1990010059A1 (en) | 1990-09-07 |
HU902289D0 (en) | 1991-11-28 |
EP0460065A1 (de) | 1991-12-11 |
DE69012105D1 (en) | 1994-10-06 |
ATE110770T1 (de) | 1994-09-15 |
AU5196590A (en) | 1990-09-26 |
AU645488B2 (en) | 1994-01-20 |
DE69012105T2 (de) | 1994-12-22 |
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